Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1963; 10(01): 146-150DOI: 10.1055/s-0038-1654770 Originalarbeiten — Original Article — Travaux Originaux Schattauer GmbH The Effect of Aminopterin Sodium on Plasma Fibrinogen, Antifibrinolysin and Euglobulin Lysis Time[*] J Frederic Johnson 1 Department of Physiology and Pharmacology, Wayne State University College of Medicine, Detroit, Michigan, USA , Rashid A Zeineh 1 Department of Physiology and Pharmacology, Wayne State University College of Medicine, Detroit, Michigan, USA › Author Affiliations Recommend Article Abstract Buy Article Summary The daily oral administration of Aminopterin Sodium to normal dogs was accompanied by an increase in plasma antifibrinolysin concentration, an increase in plasma fibrinogen concentration and a decrease in euglobulin fibrinolytic activity. Full Text References References 1 Guest M. M, Ware A. G, Seegers W. H. A Quantitative Study of Antifibrinolysin in Chick Plasma: Increase in Antifibrinolysin Activity During Pteroylglutamic Acid Deficiency. Amer. J. Physol. 150: 661 1947; 2 Dameshek W, Freedman M. H, Steinberg L. Folic Acid Antagonists in the Treatment of Acute and Subacute Leukemia. Blood 05: 898 1950; 3 Stirland R. M, Camb M. B. A Rapid Method of Estimating Fibrinogen. Lancet 01: 672 1956; 4 Ware A. G, Guest M. M, Seegers W. H. Fibrinogen: With Special Reference to its Preparation and Certain Properties of the Product. Arch. Biochem. 13: 231 1947; 5 Kowalskij E, Kopec M, Niewiarowski S. An Evaluation of the Euglobulin Method for the Determination of Fibrinolysis. J. clin. Path. 12: 215 1959; 6 Fearnley G. R. Spontaneous Fibrinolysis. Amer. J. of Cardiol. Symposium on Fibrinolysis. 371 August 1960 7 Whipple G. H, Hurwitz S. F. Fibrinogen of the Blood as Influenced by the Liver Necrosis of Chloroform Poisoning. J. exp. Med. 13: 136 1911; 8 Elliot F. A, Buckel M. Fibrinogen Changes in Relation to Cerebrovascular Accidents. Neurology 11: 120 1961; 9 Ingram G. I. C. Plasma Fibrinogen Concentration in Occlusive Arterial Disease. Edinb. med. J. 59: 94 1952; 10 Adelson E, Rheingold J. J, Parker O, Buenaventura A, Crosby W. H. Platelets and Fibrinogen Survival in Normal and Abnormal State of Coagulation. Blood 17: 267 1961; 11 Gerdes K, Maurer W. Evaluation of the Life Span of Fibrinogen in Man and Rabbit. Biochem. Z. 328: 552 1957; 12 Hammond J. D. S, Verel D. Observations on the Distribution and Biological Half-life of Human Fibrinogen. Brit. J. Haemat. 05: 431 1959; 13 Madden R. E, Gould R. G. The Turnover Rate of Fibrinogen in the Dog. J. biol. Chem. 196: 641 1952; 14 Volwiler W, Goldsworthy P. D, MacMartin M. P, Wood P. A, MacKay I. R, Fermont-Smith K. Biosynthetic Determination with Radioactive Sulfur of Turn-over Rates of Various Plasma Proteins in Normal and Cirrhotic Man. J. clin. Invest. 34: 1126 1955;
