Factor V Leiden, C>T MTHFR Polymorphism and Genetic Susceptibility to Preeclampsia

Elvira Grandone; Maurizio Margaglione; Donatella Colaizzo; Giuseppe Cappucci; Dario Paladini; Pasquale Martinelli; Sergio Montanaro; G Pavone; Giovanni Di Minno

doi:10.1055/s-0038-1656110

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 77(06): 1052-1054
DOI: 10.1055/s-0038-1656110

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Schattauer GmbH Stuttgart

Factor V Leiden, C>T MTHFR Polymorphism and Genetic Susceptibility to Preeclampsia

Elvira Grandone

Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy

,

Maurizio Margaglione

Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy

,

Donatella Colaizzo

Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy

,

Giuseppe Cappucci

Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy

,

Dario Paladini

¹Department of Obstetrics and Gynecology, University "Federico II", Naples, University of Palermo, Italy

,

Pasquale Martinelli

¹Department of Obstetrics and Gynecology, University "Federico II", Naples, University of Palermo, Italy

,

Sergio Montanaro

Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy

,

G Pavone

Arteriosclerosis and Thrombosis Unit and Division of Obstetrics and Gynecology, I.R.C.C.S. "Casa Sollievo della Sofferenza", S.Giovanni R. (FG), University of Palermo, Italy

,

Giovanni Di Minno

²Institute of Internal Medicine and Geriatrics, University of Palermo, Italy

› Author Affiliations

Abstract

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Summary

We performed a case-controlled study to investigate whether the FV Leiden mutation and the C>T⁶⁷⁷ polymorphism of the 5,10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers were 10 (10.5%) in cases and 3 (2.3%) in controls (OR: 4.9, 95% Cl: 1.3-18.3). MTHFR TT homozygotes were 28 (29.8%) in cases and 24 (18.6%) in the control group (OR: 1.8,95% Cl 1.0-3.5). No difference in any of the polymorphisms was found between proteinuric (n = 45) and non-proteinur-ic (n = 51) patients. Moreover, MTHFR polymorphism does not affect the association between FV Leiden and preeclampsia. In conclusion, FV Leiden mutation and MTHFR TT genotype are associated with the occurrence of preeclampsia, suggesting that, during pregnancy, women carrying these gene variants are prone to develop such a complication.

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References

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