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Thromb Haemost 1997; 77(06): 1189-1195
DOI: 10.1055/s-0038-1656136
Vessel Wall
Schattauer GmbH Stuttgart

Angiotensin II Increases Plasminogen Activator Inhibitor-1 and Tissue Factor mRNA Expression without Changing that of Tissue Type Plasminogen Activator or Tissue Factor Pathway Inhibitor in Cultured Rat Aortic Endothelial Cells

Hiromi Nishimura
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Hajime Tsuji
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Haruchika Masuda
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Katsumi Nakagawa
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Yoshihumi Nakahara
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Hidetsugu Kitamura
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Teruhisa Kasahara
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Tatsuya Sugano
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Masami Yoshizumi
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Shohei Sawada
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
,
Masao Nakagawa
The Second Department of Medicine, Kyoto Prefecturai University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan
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Publikationsverlauf

Received 27. November 1996

Accepted after resubmisssion 05. März 1997

Publikationsdatum:
12. Juli 2018 (online)

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Summary

Angiotensin converting enzyme inhibitors (ACE-I) have been reported to prevent the recurrence of cardiovascular events. The mechanism of this decrease, however, can not be completely explained by anti-hypertensive and anti-hypertrophic effects of ACE-I. To investigate the mechanism of this decrease, we studied the regulation of plasminogen activator inhibitor-1 (PAI-1), tissue type plasminogen activator (TPA), tissue factor (TF), and tissue factor pathway inhibitor (TFPI) by angiotensin II (Ang II) in cultured rat aortic endothelial cells. Ang II increased PAI-1 and TF mRNA expression without affecting that of TPA or TFPI. These inductions were accompanied by increases in PAI-1 and TF activities and were inhibited by a type 1 Ang II receptor antagonist. The results suggest that Ang II decreases the antithrombotic properties of endothelial cells which increases the chance of thrombosis. Thus, inhibition of the renin-angiotensin system may be beneficial to prevent thrombus formation in treatment of ischemic heart disease.

 

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