Platelet Function in Surgical Stress

O Naesh; J T Friis; I Hindberg; K Winther

doi:10.1055/s-0038-1660146

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1985; 54(04): 849-852
DOI: 10.1055/s-0038-1660146

Original Article

Schattauer GmbH Stuttgart

Platelet Function in Surgical Stress

O Naesh

¹The Department of Gastroenterological Surgery, Kommunehospitalet, Copenhagen, Denmark

,

J T Friis

¹The Department of Gastroenterological Surgery, Kommunehospitalet, Copenhagen, Denmark

,

I Hindberg

²The Department of Clinical Chemistry, Kommunehospitalet, Copenhagen, Denmark

,

K Winther

³Frederiksberg Hospital and Coagulation Laboratory, Kommunehospitalet, Copenhagen, Denmark

› Author Affiliations

Abstract

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Summary

Ten patients for elective cholecystectomy were studied pre-, per- and postoperatively. All had neurolept anesthesia. Plasma concentrations of β-TG, TXB₂ and 5-HT and intraplatelet 5-HT were measured. Aggregation to ADP was recorded.

Serum cortisol concentration was used as index of the stress response, showing peroperative increase and postoperative decrease. Closely related to this we observed a significant increase in P-β-TG and P-TXB₂ with postoperative normalization in 6 patients without complications. P-5-HT had a peak peropera-tively and remained elevated postoperatively. A negative correlation between P--5-HT and decreasing intraplatelet 5-HT postoperatively was observed.

High postoperative levels of P--5-HT seem to be related to low arterial Po₂ and pulmonary dysfunction. In 3 patients with complications a second increase in P-β-TG, P-TXB₂ and partly in P--5-HT was found. Platelets were temporarily refractory to ADP immediately following surgery and showed increased aggregabil-ity postoperatively. We conclude that platelets are activated in surgical stress.

Key words

Platelet activation - Surgical stress - Beta-thromboglobulin - Thromboxane - 5-hydroxytryptamine

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References

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