The Impact of Sperm and Egg Donation on the Risk of Pregnancy Complications

Michal Fishel Bartal; Baha M. Sibai; Yossi Bart; Avi Shina; Shali Mazaki-Tovi; Irit Schushan Eisen; Israel Hendler; Micha Baum; Eyal Schiff

doi:10.1055/s-0038-1667029

American Journal of Perinatology, Table of Contents

Am J Perinatol 2019; 36(02): 205-211
DOI: 10.1055/s-0038-1667029

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Impact of Sperm and Egg Donation on the Risk of Pregnancy Complications

Authors

Michal Fishel Bartal

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel
Baha M. Sibai

²Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), Houston, Texas
Yossi Bart

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel
Avi Shina

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel
Shali Mazaki-Tovi

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel
Irit Schushan Eisen

³Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Gan, Tel-Aviv, Israel
Israel Hendler

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel
Micha Baum^*

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel
Eyal Schiff^*

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Tel-Aviv, Israel

Abstract

Objective The aim of this study was to evaluate obstetric outcomes in relation to the extent of donor sperm exposure with and without egg donation.

Materials and Methods This is a retrospective cohort study in a single tertiary care center. All women with a singleton pregnancy who conceived following sperm donation (SD) were included. Obstetrics and neonatal outcomes for pregnancies following single SD were compared with pregnancies following repeat SD from the same donor. In a secondary analysis, we compared pregnancy outcomes among three modes of assisted reproductive technology (intrauterine insemination [IUI-SD], in vitro fertilization [IVF-SD], and IVF sperm + egg donation [IVF-SD + ED]).

Results A total of 706 pregnant women met the inclusion criteria, 243 (34.4%) following the first SD and 463 (65.6%) following repeat donations. Compared with repeat SDs, single donation was not associated with higher rates of preterm delivery (12.8 vs. 12.7%, respectively, p = 0.99), preeclampsia (7.0 vs. 6.9%, p = 0.999), and intrauterine growth restriction (4.1 vs. 3.9%, p = 0.88). Pregnancies following IVF-SD + ED had increased risk for preeclampsia (adjusted odds ratio [AOR], 3.1; 95% confidence interval [CI], 1.5–6.6), preterm labor (AOR, 2.4; 95% CI, 1.1–5.4), and cesarean section (AOR, 2.1; 95% CI, 1.0–4.3) compared with IUI-SD and IVF-SD.

Conclusion The extent of donor sperm exposure did not correlate with obstetrics complications, but double gamete donation was associated with increased risk for preeclampsia, preterm labor, and cesarean section.

Keywords

sperm donation - intrauterine insemination - prenatal - egg donation

Full Text

References

References
1 Olayemi O, Strobino D, Aimakhu C. , et al. Influence of duration of sexual cohabitation on the risk of hypertension in nulliparous parturients in Ibadan: a cohort study. Aust N Z J Obstet Gynaecol 2010; 50 (01) 40-44
2 Einarsson JI, Sangi-Haghpeykar H, Gardner MO. Sperm exposure and development of preeclampsia. Am J Obstet Gynecol 2003; 188 (05) 1241-1243
3 Verwoerd GR, Hall DR, Grové D, Maritz JS, Odendaal HJ. Primipaternity and duration of exposure to sperm antigens as risk factors for pre-eclampsia. Int J Gynaecol Obstet 2002; 78 (02) 121-126
4 Morcos RN, Bourguet CC, Gill PP. , et al. Pregnancy-induced hypertension and duration of sexual cohabitation. J Reprod Med 2000; 45 (03) 207-212
5 Gratacós E, Torres PJ, Cararach V, Quinto L, Alonso PL, Fortuny A. Does the use of contraception reduce the risk of pregnancy-induced hypertension?. Hum Reprod 1996; 11 (10) 2138-2141
6 Robillard PY, Hulsey TC. Association of pregnancy-induced-hypertension, pre-eclampsia, and eclampsia with duration of sexual cohabitation before conception. Lancet 1996; 347 (9001): 619
7 Robillard PY, Hulsey TC, Périanin J, Janky E, Miri EH, Papiernik E. Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception. Lancet 1994; 344 (8928): 973-975
8 Ness RB, Markovic N, Harger G, Day R. Barrier methods, length of preconception intercourse, and preeclampsia. Hypertens Pregnancy 2004; 23 (03) 227-235
9 Mills JL, Klebanoff MA, Graubard BI, Carey JC, Berendes HW. Barrier contraceptive methods and preeclampsia. JAMA 1991; 265 (01) 70-73
10 Adams DH, Clark RA, Davies MJ, de Lacey S. A meta-analysis of sperm donation offspring health outcomes. J DevOrig Health Dis 2017; 8 (01) 44-55
11 Lansac J, Royere D. Follow-up studies of children born after frozen sperm donation. Hum Reprod Update 2001; 7 (01) 33-37
12 Salha O, Sharma V, Dada T. , et al. The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 1999; 14 (09) 2268-2273
13 González-Comadran M, Urresta Avila J, SaavedraTascón A. , et al. The impact of donor insemination on the risk of preeclampsia: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol 2014; 182: 160-166
14 Smith GN, Walker M, Tessier JL, Millar KG. Increased incidence of preeclampsia in women conceiving by intrauterine insemination with donor versus partner sperm for treatment of primary infertility. Am J Obstet Gynecol 1997; 177 (02) 455-458
15 Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y. The role of the immune system in preeclampsia. Mol Aspects Med 2007; 28 (02) 192-209
16 Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365 (9461): 785-799
17 Practice Committee of American Society for Reproductive Medicine; Practice Committee of Society for Assisted Reproductive Technology. Recommendations for gamete and embryo donation: a committee opinion. Fertil Steril 2013; 99 (01) 47-62
18 Practice Committee of American Society for Reproductive Medicine; Practice Committee of Society for Assisted Reproductive Technology. 2008 Guidelines for gamete and embryo donation: a Practice Committee report. Fertil Steril 2008; 90 (5, Suppl): S30-S44
19 Committee on Practice Bulletins—Obstetrics. ACOG Practice Bulletin No. 190: gestational diabetes mellitus. Obstet Gynecol 2018; 131 (02) e49-e64
20 Dekker GA, Robillard PY, Hulsey TC. Immune maladaptation in the etiology of preeclampsia: a review of corroborative epidemiologic studies. Obstet Gynecol Surv 1998; 53 (06) 377-382
21 Robillard PY, Hulsey TC, Alexander GR, Keenan A, de Caunes F, Papiernik E. Paternity patterns and risk of preeclampsia in the last pregnancy in multiparae. J Reprod Immunol 1993; 24 (01) 1-12
22 Li DK, Wi S. Changing paternity and the risk of preeclampsia/eclampsia in the subsequent pregnancy. Am J Epidemiol 2000; 151 (01) 57-62
23 Hoy J, Venn A, Halliday J, Kovacs G, Waalwyk K. Perinatal and obstetric outcomes of donor insemination using cryopreserved semen in Victoria, Australia. Hum Reprod 1999; 14 (07) 1760-1764
24 Gerkowicz SA, Crawford SB, Hipp HS, Boulet SL, Kissin DM, Kawwass JF. Assisted reproductive technology with donor sperm: national trends and perinatal outcomes. Am J Obstet Gynecol 2018; 218 (04) 421.e1-421.e10
25 Lansac J, Thepot F, Mayaux MJ. , et al. Pregnancy outcome after artificial insemination or IVF with frozen semen donor: a collaborative study of the French CECOS Federation on 21,597 pregnancies. Eur J Obstet Gynecol Reprod Biol 1997; 74 (02) 223-228
26 Robertson SA, Prins JR, Sharkey DJ, Moldenhauer LM. Seminal fluid and the generation of regulatory T cells for embryo implantation. Am J Reprod Immunol 2013; 69 (04) 315-330
27 Tarlatzi TB, Imbert R, Alvaro Mercadal B. , et al. Does oocyte donation compared with autologous oocyte IVF pregnancies have a higher risk of preeclampsia?. Reprod Biomed Online 2017; 34 (01) 11-18
28 Storgaard M, Loft A, Bergh C. , et al. Obstetric and neonatal complications in pregnancies conceived after oocyte donation-a systematic review and meta-analysis. BJOG 2017; 124 (04) 561-572
29 Jeve YB, Potdar N, Opoku A, Khare M. Three-arm age-matched retrospective cohort study of obstetric outcomes of donor oocyte pregnancies. Int J Gynaecol Obstet 2016; 133 (02) 156-158
30 Malchau SS, Loft A, Larsen EC. , et al. Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study. Fertil Steril 2013; 99 (06) 1637-1643
31 Stoop D, Baumgarten M, Haentjens P. , et al. Obstetric outcome in donor oocyte pregnancies: a matched-pair analysis. Reprod Biol Endocrinol 2012; 10: 42
32 Blázquez A, Vassena R, Rodríguez A, Figueras F, Vernaeve V. Characteristics and clinical outcomes of patients undergoing fertility treatment by double gamete donation. Hum Fertil (Camb) 2016; 19 (03) 180-185
33 Blázquez A, García D, Rodríguez A, Vassena R, Vernaeve V. Use of donor sperm in addition to oocyte donation after repeated implantation failure in normozoospermic patients does not improve live birth rates. Hum Reprod 2016; 31 (11) 2549-2553
34 Preaubert L, Vincent-Rohfritsch A, Santulli P, Gayet V, Goffinet F, Le Ray C. Outcomes of pregnancies achieved by double gamete donation: a comparison with pregnancies obtained by oocyte donation alone. Eur J Obstet Gynecol Reprod Biol 2018; 222: 1-6