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Am J Perinatol 2019; 36(10): 1072-1078
DOI: 10.1055/s-0038-1675644
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Systemic Arterial Hypertension in Childhood: A Challenge Related to the Increasing Survival of Very Low Birth Weight Preterm Infants

Bruna Ossanai Schoenardie
1   Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
,
Victória Bernardes Guimarães
2   School of Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil
,
Renato Soibelmann Procianoy
3   Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
4   Neonatology Section, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
,
Rita C. Silveira
3   Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
4   Neonatology Section, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
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Publikationsverlauf

18. Juli 2018

25. September 2018

Publikationsdatum:
11. Dezember 2018 (online)

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Abstract

Objective To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants.

Study Design This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Model 1 compared children with and those without SAH at age 4. Model 2 compared children who had SAH at ages 2 and 4 with the others. SAH was diagnosed if the systolic or/and diastolic pressures were above the 95th percentile.

Results A total of 198 patients were included during the 5-year study period, of whom 56% had SAH at age 4. In model 1, white matter injury (WMI) and catch-up growth at age 2 were predictors of SAH at age 4. In model 2, bronchopulmonary dysplasia, WMI, catch-up growth at age 2, and BW were predictors of SAH at 2 and 4 years. SAH at age 2 was an independent risk factor for SAH at age 4. After a multivariate analysis of model 2, BW and catch-up growth were associated with SAH.

Conclusion Prevalence of SAH was high in VLBW infants; it was associated with low BW and catch-up growth at age 2.

Keywords

systemic arterial hypertension - prematurity - early childhood - neonate - child
 

  • References

  • 1 Whelton P, Carey R, Aronow W. , et al. Correction to: 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 2018; 71 (06) e136-e139
    PubMedSuche in Google Scholar
  • 2 Rapsomaniki E, Timmis A, George J. , et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. Lancet 2014; 383 (9932): 1899-1911
    CrossrefPubMedSuche in Google Scholar
  • 3 Picon RV, Fuchs FD, Moreira LB, Riegel G, Fuchs SC. Trends in prevalence of hypertension in Brazil: a systematic review with meta-analysis. PLoS One 2012; 7 (10) e48255
    CrossrefPubMedSuche in Google Scholar
  • 4 Sharma AK, Metzger DL, Rodd CJ. Prevalence and severity of high blood pressure among children based on the 2017 American Academy of Pediatrics Guidelines. JAMA Pediatr 2018; 172 (06) 557-565
    CrossrefPubMedSuche in Google Scholar
  • 5 Morrison K, Ramsingh L, Gunn E. , et al. Cardiometabolic health in adults born premature with extremely low birth weight. Pediatrics 2016; 138 (04) e20160515
    CrossrefPubMedSuche in Google Scholar
  • 6 Hack M, Schluchter M, Cartar L, Rahman M. Blood pressure among very low birthweight (< 1.5 kg) young adults. Pediatr Res 2005; 58 (04) 677-684
    CrossrefPubMedSuche in Google Scholar
  • 7 Hovi P, Vohr B, Ment LR. , et al; APIC Adults Born Preterm International Collaboration. Blood pressure in young adults born at very low birth weight: Adults Born Preterm International Collaboration. Hypertension 2016; 68 (04) 880-887
    CrossrefPubMedSuche in Google Scholar
  • 8 Flynn JT, Kaelber DC, Baker-Smith CM. , et al; SUBCOMMITTEE ON SCREENING AND MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN. Clinical Practice Guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 2017; 140 (03) e20171904
    CrossrefPubMedSuche in Google Scholar
  • 9 de Jong F, Monuteaux MC, van Elburg RM, Gillman MW, Belfort MB. Systematic review and meta-analysis of preterm birth and later systolic blood pressure. Hypertension 2012; 59 (02) 226-234
    CrossrefPubMedSuche in Google Scholar
  • 10 Vohr BR, Allan W, Katz KH, Schneider KC, Ment LR. Early predictors of hypertension in prematurely born adolescents. Acta Paediatr 2010; 99 (12) 1812-1818
    CrossrefPubMedSuche in Google Scholar
  • 11 Seliem WA, Falk MC, Shadbolt B, Kent AL. Antenatal and postnatal risk factors for neonatal hypertension and infant follow-up. Pediatr Nephrol 2007; 22 (12) 2081-2087
    CrossrefPubMedSuche in Google Scholar
  • 12 Belfort MB, Gillman MW, McCormick MC. Prenatal and perinatal predictors of blood pressure at school age in former preterm, low birth weight infants. J Perinatol 2012; 32 (04) 265-269
    CrossrefPubMedSuche in Google Scholar
  • 13 Roberts G, Lee KJ, Cheong JL, Doyle LW. ; Victorian Infant Collaborative Study Group. Higher ambulatory blood pressure at 18 years in adolescents born less than 28 weeks' gestation in the 1990s compared with term controls. J Hypertens 2014; 32 (03) 620-626
    CrossrefPubMedSuche in Google Scholar
  • 14 Luyckx VA, Brenner BM. Birth weight, malnutrition and kidney-associated outcomes--a global concern. Nat Rev Nephrol 2015; 11 (03) 135-149
    PubMedSuche in Google Scholar
  • 15 Hughson M, Farris III AB, Douglas-Denton R, Hoy WE, Bertram JF. Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 2003; 63 (06) 2113-2122
    CrossrefPubMedSuche in Google Scholar
  • 16 Mañalich R, Reyes L, Herrera M, Melendi C, Fundora I. Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 2000; 58 (02) 770-773
    CrossrefPubMedSuche in Google Scholar
  • 17 Gurusinghe S, Tambay A, Sethna CB. Developmental origins and nephron endowment in hypertension. Front Pediatr 2017; 5: 151
    CrossrefPubMedSuche in Google Scholar
  • 18 Keller G, Zimmer G, Mall G, Ritz E, Amann K. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348 (02) 101-108
    CrossrefPubMedSuche in Google Scholar
  • 19 Parkinson JR, Hyde MJ, Gale C, Santhakumaran S, Modi N. Preterm birth and the metabolic syndrome in adult life: a systematic review and meta-analysis. Pediatrics 2013; 131 (04) e1240-e1263
    CrossrefPubMedSuche in Google Scholar
  • 20 Kopec G, Shekhawat PS, Mhanna MJ. Prevalence of diabetes and obesity in association with prematurity and growth restriction. Diabetes Metab Syndr Obes 2017; 10: 285-295
    CrossrefPubMedSuche in Google Scholar
  • 21 Luyckx VA. Preterm birth and its impact on renal health. Semin Nephrol 2017; 37 (04) 311-319
    CrossrefPubMedSuche in Google Scholar
  • 22 Skinner AC, Perrin EM, Moss LA, Skelton JA. Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med 2015; 373 (14) 1307-1317
    CrossrefPubMedSuche in Google Scholar
  • 23 Tenhola S, Rahiala E, Halonen P, Vanninen E, Voutilainen R. Maternal preeclampsia predicts elevated blood pressure in 12-year-old children: evaluation by ambulatory blood pressure monitoring. Pediatr Res 2006; 59 (02) 320-324
    CrossrefPubMedSuche in Google Scholar
  • 24 Vatten LJ, Romundstad PR, Holmen TL, Hsieh CC, Trichopoulos D, Stuver SO. Intrauterine exposure to preeclampsia and adolescent blood pressure, body size, and age at menarche in female offspring. Obstet Gynecol 2003; 101 (03) 529-533
    PubMedSuche in Google Scholar
  • 25 Seidman D, Laor A, Gale R, Stevenson D, Mashiach S, Danon Y. Pre-eclampsia and offpsringʼs blood pressure, cognitive ability and physical development at 17-years-of-age. Obstet Gynecol Surv 1992; 47 (06) 373-374
    CrossrefPubMedSuche in Google Scholar
  • 26 Rotteveel J, van Weissenbruch MM, Twisk JW, Delemarre-Van de Waal HA. Infant and childhood growth patterns, insulin sensitivity, and blood pressure in prematurely born young adults. Pediatrics 2008; 122 (02) 313-321
    CrossrefPubMedSuche in Google Scholar
  • 27 Mhanna MJ, Iqbal AM, Kaelber DC. Weight gain and hypertension at three years of age and older in extremely low birth weight infants. J Neonatal Perinatal Med 2015; 8 (04) 363-369
    PubMedSuche in Google Scholar
  • 28 Huxley RR, Shiell AW, Law CM. The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature. J Hypertens 2000; 18 (07) 815-831
    CrossrefPubMedSuche in Google Scholar
  • 29 Heidemann LA, Procianoy RS, Silveira RC. Prevalence of metabolic syndrome-like in the follow-up of very low birth weight preterm infants and associated factors. J Pediatr (Rio J) 2018;
    CrossrefPubMedSuche in Google Scholar