Functionalised Nitrogen Heterocycles and the Search for New Antibacterials and Bioactives

Muhammad Kamran Khan; Dandan Wang; Mark G. Moloney

doi:10.1055/s-0039-1690089

Synthesis, Table of Contents

Synthesis 2020; 52(11): 1602-1616
DOI: 10.1055/s-0039-1690089

short review

Functionalised Nitrogen Heterocycles and the Search for New Antibacterials and Bioactives

Muhammad Kamran Khan

^aOxford Suzhou Centre for Advanced Research, Building A, 388 Ruo Shui Road, Suzhou Industrial Park, Jiangsu, 215123, P. R. of China

,

Dandan Wang

^aOxford Suzhou Centre for Advanced Research, Building A, 388 Ruo Shui Road, Suzhou Industrial Park, Jiangsu, 215123, P. R. of China

,

Mark G. Moloney∗

^aOxford Suzhou Centre for Advanced Research, Building A, 388 Ruo Shui Road, Suzhou Industrial Park, Jiangsu, 215123, P. R. of China

^bThe Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, Email: mark.moloney@chem.ox.ac.uk

› Author Affiliations

Abstract

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Abstract

The importance of, and synthetic routes to, pyrrolidines and piperidines, along with their relevance to natural product synthesis and antibacterial drug discovery, are surveyed in the context of an extended programme of investigation from our own laboratories.

1 Introduction

2 Pyroglutamates

2.1 Synthesised by Modification of an Existing Ring

2.2 Synthesised by Construction of a New Ring

3 Tetramates

4 Metal Chelation

5 Biological Activity

6 Conclusion

Key words

nitrogen heterocycles - antibacterials - bioactives - pyrrolidines - piperidines - natural products

Full Text

References

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