Functionalised Nitrogen Heterocycles and the Search for New Antibacterials and Bioactives

Abstract

The importance of, and synthetic routes to, pyrrolidines and piperidines, along with their relevance to natural product synthesis and antibacterial drug discovery, are surveyed in the context of an extended programme of investigation from our own laboratories.

1 Introduction

2 Pyroglutamates

2.1 Synthesised by Modification of an Existing Ring

2.2 Synthesised by Construction of a New Ring

3 Tetramates

4 Metal Chelation

5 Biological Activity

6 Conclusion

Key words

nitrogen heterocycles - antibacterials - bioactives - pyrrolidines - piperidines - natural products

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