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Synlett 2019; 30(18): 2096-2100
DOI: 10.1055/s-0039-1690697
DOI: 10.1055/s-0039-1690697
letter
Silver-Promoted Versatile Cross-Dehydrogenative Coupling of Quinaldine with Usual Ethers
Financial support from the Shandong Provincial Natural Science Foundation (Grant numbers ZR2016HM44, ZR2016BQ31, and ZR2016JL009), the Shandong Key Research Program (Grant number 2017GSF218061), the Major Program of Shandong Province Natural Science Foundation (Grant number ZR2017ZC0529) of China and University of Jinan is gratefully acknowledged.Further Information
Publication History
Received: 01 July 2019
Accepted after revision: 18 September 2019
Publication Date:
07 October 2019 (online)
Abstract
The application of small molecules as synthetic blocks is a field of great meaning and full of challenges, especially the use of inert ether molecules, such as THF as starting materials. A versatile and easily handled cross-dehydrogenative coupling between ethers and quinaldine is reported here. Compared to the developed reaction, Selectfluor is used as a mild oxidant, and a variety of functional groups are tolerated. Nitrogen protection, anhydrous systems, and external base are not needed, making this method a convenient route to functional heterocycles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690697.
- Supporting Information
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