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Synthesis 2020; 52(02): 189-196
DOI: 10.1055/s-0039-1690713
DOI: 10.1055/s-0039-1690713
short review
Stereoselective Preparation and Reactions of Chiral Secondary Alkyllithiums
We thank the SFB 749 for financial support. J.S. thanks the FCI foundation for a fellowship.Further Information
Publication History
Received: 16 September 2019
Accepted after revision: 20 September 2019
Publication Date:
08 October 2019 (online)
In memory of Prof. Dr. Dieter Enders
Abstract
The preparation of chiral non-stabilized open-chain alkyllithium reagents prepared from the corresponding chiral secondary alkyl iodides and their subsequent transmetalation to the corresponding secondary alkylcopper or alkylzinc derivatives is reviewed. These new organometallic reagents allow the stereoselective preparation of a broad range of chiral molecules.
1 Introduction
2 Stereoselective Preparation of Secondary Alkyllithiums
3 Preparation of Stereodefined Secondary Alkylcopper Reagents
4 Preparation of Stereodefined Secondary Alkylzinc Derivatives and Their Stereoselective Cross-Coupling with Alkenyl and Aryl Halides
5 Conclusion
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