Practical Preparation of Cyclopropenone 1,3-Propanediol Ketal

Abstract

Cyclopropenone 1,3-propanediol ketal is an increasingly versatile building block for the introduction of various C₃ and dioxaspiro units due to the emergence of numerous methodologies for the application of strained hydrocarbons. This Practical Synthetic Procedure gives an updated synthesis for a basic ketal of cyclopropenone with lowered solvent toxicity and a detailed step-by-step guide for the safe production of potassium amide in liquid ammonia and for its application in the synthesis of the cyclopropene ring.

Key words

acetals - bicyclic compounds - carbocycles - condensation - cyclization - elimination - ring closure

• References

• 1 New address: F. F. Mulks, Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, 3012 Bern, Switzerland.
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