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Synthesis 2020; 52(08): 1279-1286
DOI: 10.1055/s-0039-1691589
DOI: 10.1055/s-0039-1691589
paper
Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions
The authors would like to thank the South African National Research Foundation (grant numbers 105213 and 105236), Aspen Pharmacare, and the South African Medical Research Council for their support.Further Information
Publication History
Received: 19 November 2019
Accepted after revision: 20 December 2019
Publication Date:
29 January 2020 (online)
Abstract
An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines was developed. The reaction took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in moderate to excellent yields (27 examples). This protocol proved to be rapid, easy to handle, and applicable to a broad scope of substrates.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691589.
- Supporting Information
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