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Semin Plast Surg 2019; 33(03): 167-172
DOI: 10.1055/s-0039-1693131
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Evolving Landscape of Gene Therapy in Plastic Surgery

Anjali Raghuram
1   Baylor College of Medicine, Houston, Texas
,
Aspinder Singh
2   Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Daniel K. Chang
3   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Mervin Nunez
3   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Edward M. Reece
3   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
,
Brent E. Schultz
4   Private Practice, Eugene, Oregon
› Author Affiliations
Further Information

Publication History

Publication Date:
02 August 2019 (online)

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Abstract

With the rapid rise of personalized genomic sequencing and clustered regularly interspaced short palindromic repeat (CRISPR) technology, previous gaps in gene therapy are beginning to be bridged, paving the way for increasing clinical applicability. This article aims to provide an overview of the fundamentals of gene therapy and discuss future potential interventions relevant to plastic surgeons. These interventions include enhancing tissue regeneration and healing, as well as modifying disease processes in congenital anomalies. Though clinical applications are still on the horizon, a deeper understanding of these new advances will help plastic surgeons understand the current landscape of gene therapy and stay abreast of future opportunities.

Keywords

gene therapy - gene delivery - CRISPR - plastic surgery
 

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