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CC BY-NC-ND 4.0 · AJP Rep 2019; 09(04): e346-e352
DOI: 10.1055/s-0039-1695743
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Adverse Pregnancy Outcomes in Women with Sickle Cell Trait[∗]

Whitney L. Wellenstein
1   Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, Oakland, California
,
Shannon Sullivan
1   Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, Oakland, California
,
Jeanne Darbinian
2   Division of Research, Kaiser Permanente Medical Center, Oakland, California
,
Miranda L. Ritterman Weintraub
3   Department of Graduate Medical Education, Kaiser Permanente Medical Center, Oakland, California
,
Mara Greenberg
1   Department of Obstetrics and Gynecology, Kaiser Permanente Medical Center, Oakland, California
› Institutsangaben
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Publikationsverlauf

08. März 2019

14. Mai 2019

Publikationsdatum:
11. November 2019 (online)

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Erratum zu diesem Artikel:

Erratum: Adverse Pregnancy Outcomes in Women with Sickle Cell TraitAJP Rep 2019; 09(04): e389-e389
DOI: 10.1055/s-0040-1701199

Abstract

Objective To compare adverse pregnancy outcomes between women with sickle cell trait (SCT) and women with normal hemoglobin.

Study Design A retrospective cohort study of women who delivered within Kaiser Permanente Northern California between 2006 and 2013. Using hemoglobin electrophoretic profiles, we defined women with hemoglobin AS (HbAS) as having SCT and those with hemoglobin AA (HbAA) as having normal hemoglobin. Outcomes were pregnancy-induced hypertension (PIH), small for gestational age (SGA), gestational diabetes (GDM), and preterm delivery (PTD). Demographic and pregnancy outcome variations were assessed in bivariate analyses. Multivariable logistic regression modeling was used to estimate odds ratios for the association between primary outcomes and selected characteristics.

Results Of 31,840 eligible women, 868 (2.7%) had SCT. Women with SCT were more likely to have PIH (15.6% vs. 12.2%, p value = 0.003) and SGA (8.3% vs. 6.1%, p value = 0.008), less likely to have GDM (6.8% vs. 9.8%, p value = 0.003) and had similar PTD prevalence (8.1% vs. 7.6%, p value = 0.600). In multivariable analyses, SCT was not an independent predictor of these outcomes. Racial/ethnic minorities had higher adjusted odds of PIH, SGA, and GDM.

Conclusion SCT alone does not appear to be associated with adverse pregnancy outcomes. Race/ethnicity is a risk factor for adverse pregnancy outcomes.

Keywords

adverse pregnancy outcomes in African American women - hemoglobinopathy in pregnancy - sickle cell trait

Financial Disclosures

None.


a University of Chicago/NorthShore University Health Systems, Department of Gynecology Oncology.


∗ ePoster presentation: 64th annual ACOG Clinical and Scientific Meeting, Washington DC, May 13, 2016


 

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