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Semin intervent Radiol 2019; 36(04): 334-342
DOI: 10.1055/s-0039-1696704
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Postablation Immune Microenvironment: Synergy between Interventional Oncology and Immuno-oncology

DaeHee Kim
1   Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
,
Joseph P. Erinjeri
1   Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York
› Author Affiliations Source of Funding This article was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748.
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Publication History

Publication Date:
31 October 2019 (online)

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Abstract

Current tumor thermal ablation techniques rely on extreme temperatures to induce irreversible cellular injury and coagulative tissue necrosis. Ablation-induced cellular injury or death releases cancer neoantigens and activates the cancer-immunity cycle, potentially generating tumor-specific immune effectors. However, multiple negative regulatory modulators exist at each step of the cycle, mitigating meaningful and therapeutic anticancer effect provided by the immune system. Recent studies have focused on the introduction and testing of adjuvant immunotherapy combined with ablation to synergistically shift the equilibrium out of inhibitory immune modulation. This article reviews the immune microenvironment in relation to image-guided ablation techniques and discusses current and upcoming novel strategies to take advantage of antitumor immunity.

Keywords

immune microenvironment - ablation - interventional oncology - immunotherapy

Disclosure Statement

The authors declare that they have no conflicts of interest.


 

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