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DOI: 10.1055/s-0039-1696976
Genetic Landscape of Mitochondrial Regulatory Region in Pediatric Acute Myeloid Leukemia: Changes from Diagnosis to Relapse
Funding We acknowledge the following funding sources: Department of Biotechnology, Government of India, under grant number BT/PR7197/MED/30/899/2012 (September 26, 2013) and AIIMS, Institutional Junior Research Fellowship grant.Publikationsverlauf
16. Mai 2019
05. August 2019
Publikationsdatum:
12. September 2019 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00029027/201904/lookinside/thumbnails/10-1055-s-0039-1696976_1900036-1.jpg)
Abstract
This prospective study aimed to compare the pattern of mitochondrial deoxyribonucleic acid D-loop (mt-DNA D-loop) variations in 41 paired samples of de novo pediatric acute myeloid leukemia (AML) (baseline vs. relapse) patients by Sanger's sequencing. Mean mt-DNA D-loop variation was 10.1 at baseline as compared with 9.4 per patients at relapse. In our study, 28 (68.3%) patients showed change in number of variations from baseline to relapse, 11 (26.8%) patients showed increase, 17 (41.6%) patients showed decrease, and 7 (17.1%) patients who suffered a relapse had a gain at position T489C. No statistically significant difference was observed in the mutation profile of mt-DNA D-loop region from baseline to relapse in the evaluated population of pediatric AML.
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