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Semin Neurol 2019; 39(06): 749-760
DOI: 10.1055/s-0039-1700527
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Update on Ocular Myasthenia Gravis

Meabh O'Hare
1   Department of Neurology, Brigham & Women's Hospital, Boston
,
Christopher Doughty
1   Department of Neurology, Brigham & Women's Hospital, Boston
› Author Affiliations
Further Information

Publication History

Publication Date:
17 December 2019 (online)

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Abstract

Myasthenia gravis is an antibody-mediated autoimmune disorder of the post-synaptic neuromuscular junction resulting in fluctuating, fatigable weakness. Most patients first present with extraocular symptoms (diplopia and/or ptosis), and in 15% of cases symptoms will remain restricted to only the extraocular muscles (ocular myasthenia gravis [OMG]). The history and clinical examination are of the utmost importance in correctly identifying OMG patients, as supportive serologic or electrodiagnostic studies are frequently nondiagnostic. In this review, we outline a diagnostic approach to OMG (focusing on key clinical features), discuss therapeutic options, and highlight recent developments in the understanding of OMG.

Keywords

ocular myasthenia gravis - ptosis - diplopia - neuromuscular junction - acetylcholine receptor antibody
 

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