Morbidity Outcomes of Very Low Birth Weight Neonates Receiving Parenteral Nutrition with Fish Oil Enriched Lipid Emulsion or Lipid Emulsion with Soybean Oil: An Observational Study

José Uberos; Sara Jiménez-Montilla; Manuel Molina-Oya; Pelayo Nieto-Gómez; Isabel Cubero Millan

doi:10.1055/s-0039-1701026

American Journal of Perinatology, Table of Contents

Am J Perinatol 2021; 38(09): 952-959
DOI: 10.1055/s-0039-1701026

Original Article

Morbidity Outcomes of Very Low Birth Weight Neonates Receiving Parenteral Nutrition with Fish Oil Enriched Lipid Emulsion or Lipid Emulsion with Soybean Oil: An Observational Study

José Uberos

¹Neonatal Intensive Care Unit, San Cecilio Clinical Hospital, Granada, Spain

²Medicine Faculty. Granada, Spain

,

Sara Jiménez-Montilla

¹Neonatal Intensive Care Unit, San Cecilio Clinical Hospital, Granada, Spain

,

Manuel Molina-Oya

¹Neonatal Intensive Care Unit, San Cecilio Clinical Hospital, Granada, Spain

,

Pelayo Nieto-Gómez

³Pharmacy Service, San Cecilio Clinical Hospital, Granada, Spain

,

Isabel Cubero Millan

¹Neonatal Intensive Care Unit, San Cecilio Clinical Hospital, Granada, Spain

› Author Affiliations

Abstract

Intralipid (Fresenius Kabi) was the most commonly used lipid emulsion in parenteral nutrition (PN), with a 100% soybean oil composition, a low vitamin E content, and a ω-6: ω-3 ratio of 7:1. A recent alternative formulation is SMOFlipid (Fresenius Kabi), with a ω-6: ω-3 ratio of 5:2 and higher vitamin E content. A retrospective observational study was conducted to determine neonatal morbidity in very low birth weight (VLBW) premature infants during two periods: P1, when PN was based exclusively on Intralipid, and P2, when only SMOFlipid was supplied. In total, 170 VLBW neonates were analyzed, of whom 103 received PN for more than 6 days, 56 during P1, and 47 during P2. In both periods, the antenatal and neonatal characteristics of the cohort were comparable. In this analysis, the prevalence of associated comorbidities was determined. During P2, there were fewer cases of moderate to severe bronchopulmonary dysplasia (BPD) and of cholestasis, but more cases of late sepsis, mainly Staphylococcus epidermidis. No changes in the prevalence of other neonatal comorbidities were observed. We believe that the SMOFlipid used in PN could discreetly improve the prevalence of cholestasis or BPD.

Keywords

parenteral nutrition - neonatal morbidity - long-chain polyunsaturated fatty acids - bronchopulmonar dysplasia - late onset sepsis - necrotizing enterocolitis - intraventricular hemorrhage - persistent ductus arteriosus

Full Text

References

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