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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2014; 04(02): 090-093
DOI: 10.1055/s-0040-1703770
Short Communication

EVALATION OF RELATIONSHIP BETWEEN MARKERS OF LIVER FUNCTION AND THE ONSET OF TYPE 2 DIABETES

Raiza Philip
1   MBBS Student (II year), Department of Physiology, K.S. Hegde Medical Academy, Nitte University, Deralakatte, Mangalore - 575 018, Karnataka, India
,
Michelle Mathias
2   Additional Professor, Department of Physiology, K.S. Hegde Medical Academy, Nitte University, Deralakatte, Mangalore - 575 018, Karnataka, India
,
Suchetha Kumari N.
3   Professor, Department of Biochemistry, K.S. Hegde Medical Academy, K.S. Hegde Medical Academy, Nitte University, Deralakatte, Mangalore - 575 018, Karnataka, India
,
Damodara Gowda K. M.
4   Assisstant Professor, Department of Physiology, K.S. Hegde Medical Academy, Nitte University, Deralakatte, Mangalore - 575 018, Karnataka, India
,
Jayaprakash Shetty K.
5   Professor & HOD, Department of Pathology, K.S. Hegde Medical Academy, Nitte University, Deralakatte, Mangalore - 575 018, Karnataka, India
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Abstract:

Background and Objective: Type 2 diabetic individuals are highly prone to liver function test abnormalities than non-diabetic individuals. Increased activities of liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and ?- glutamyl transpeptidase (GGT) are indicators of hepatocellular injury. Increased activity of these markers is associated with insulin resistance [1], metabolic syndrome, and type 2 diabetes. Diabetes mellitus burden is one of the key concerns in developing countries like India. In this study, we evaluated the relationships between markers of liver function and the onset of type 2 diabetes.

Materials and Methods: This study was conducted after the approval from institutional ethical committee. Twenty five patients reporting to the OPD of K. S. Hegde Hospital diagnosed for type 2 diabetes between the age group of 40-50 years of both sex and 25 healthy age and sex matched individuals were included in the study. Under aseptic precautions blood samples were collected and centrifuged to get serum and was used for estimation. Data were expressed as the mean ± SD. Spearman's correlation coefficients were calculated to evaluate the relationship between serum glucose and liver function enzymes.

Result: The results of the present showed that the ALT, AST and GGT levels in Type 2 Diabetic patients was increased significantly (p<0.01) as compared to normal controls.

Conclusion: In this study, we found an association between the level of liver enzymes, ALT, AST and GGT in type 2 diabetes. Thus these liver enzyme levels can be used as a biomarker for the assessment of type 2 diabetes.

Keywords:

Aspartate Aminotransferase - Alanine Aminotransferase - Gamma-Glutamyl Transpeptidase


Publication History

Article published online:
24 April 2020

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