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Synthesis 2021; 53(08): 1495-1502
DOI: 10.1055/s-0040-1705984
DOI: 10.1055/s-0040-1705984
paper
Synthesis of N-Aryl-4-arylhexahydroquinoline Derivatives by Reaction of Cyclic Enaminones with Arylidenemalononitriles in DMSO
Abstract
The reaction of cyclic enaminones with arylidenemalononitriles was carried out in the presence of 13X molecular sieves in dimethyl sulfoxide. Under these mild reaction conditions, various bioactive N-aryl-4-arylhexahydroquinoline derivatives were obtained in high yields without the necessity of using transition-metal catalyst, organobase, or reflux conditions.
Key words
dimethyl sulfoxide - molecular sieves - cyclic enaminones - arylidenemalononitriles - N-aryl-4-arylhexahydroquinolinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1705984.
- Supporting Information
Publication History
Received: 23 September 2020
Accepted after revision: 12 November 2020
Article published online:
08 December 2020
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For selected examples, see:
For selected examples, see:
For catalyst-free reactions in DMSO reported by our group, see: