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Synlett 2021; 32(18): 1784-1795
DOI: 10.1055/s-0040-1706031
DOI: 10.1055/s-0040-1706031
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Suzuki–Miyaura Coupling Reactions of Fluorohalobenzenes
Dedicated to Professor Ralf Miethchen on the occasion of his 80th birthday
Abstract
Organofluorine compounds have gained interest in the fields of pharmaceuticals, agrochemicals, diagnostics, materials, and catalysis. Suzuki–Miyaura coupling reactions of fluorinated arenes made a tremendous impact in chemical and biological research and made organofluorinated molecules more readily available. This review gives a brief summary of Suzuki–Miyaura coupling reactions of fluorinated benzene derivatives. In this context, various aspects, such as regioselectivity, efficiency, and applications, are discussed.
1 Introduction
2 Organofluorine Compounds
3 Suzuki–Miyaura Reactions of Fluorohalobenzenes
3.1 Fluorophthalates
3.2 Reactions of Pentafluorohalobenzenes
3.3 Tetrafluorohalobenzenes
3.4 Trifluorohalobenzenes
3.5 Difluorohalobenzenes
3.6 Monofluorohalobenzenes
3.7 Halo(trifluoromethyl)benzenes
3.8 Trifluoromethyl Pyridines
4 S Summary
Publication History
Received: 17 February 2021
Accepted after revision: 27 February 2021
Article published online:
01 April 2021
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