Suzuki–Miyaura Coupling Reactions of Fluorohalobenzenes

Dedicated to Professor Ralf Miethchen on the occasion of his 80^th birthday

Abstract

Organofluorine compounds have gained interest in the fields of pharmaceuticals, agrochemicals, diagnostics, materials, and catalysis. Suzuki–Miyaura coupling reactions of fluorinated arenes made a tremendous impact in chemical and biological research and made organofluorinated molecules more readily available. This review gives a brief summary of Suzuki–Miyaura coupling reactions of fluorinated benzene derivatives. In this context, various aspects, such as regio­selectivity, efficiency, and applications, are discussed.

1 Introduction

2 Organofluorine Compounds

3 Suzuki–Miyaura Reactions of Fluorohalobenzenes

3.1 Fluorophthalates

3.2 Reactions of Pentafluorohalobenzenes

3.3 Tetrafluorohalobenzenes

3.4 Trifluorohalobenzenes

3.5 Difluorohalobenzenes

3.6 Monofluorohalobenzenes

3.7 Halo(trifluoromethyl)benzenes

3.8 Trifluoromethyl Pyridines

4 S Summary

Keywords

arenes - catalysis - fluorine - Suzuki–Miyaura reaction

Publication History

Received: 17 February 2021

Accepted after revision: 27 February 2021

Article published online:
01 April 2021

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