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Synlett 2021; 32(06): 611-615
DOI: 10.1055/s-0040-1706641
DOI: 10.1055/s-0040-1706641
letter
Efficient Copper-Catalysed Synthesis of Carbazoles by Double N-Arylation of Primary Amines with 2,2′-Dibromobiphenyl in the Presence of Air
This research was supported by the Institute of Chemistry of the VAST (Grant Number VHH.2020.1.01).
Abstract
An efficient Cu-catalyzed synthesis of carbazole derivatives is reported, which proceeds by double C–N coupling reactions of 2,2′-dibromobiphenyl and amines in the presence of air. The reaction is robust, proceeds in high yields, and tolerates a series of amines including neutral, electron-rich, electron-deficient aromatic amines and aliphatic amines.
Key words
Cu catalysis - carbazole synthesis - C–N coupling - carbazole alkaloids - sustainable processSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1706641.
- Supporting Information
Publication History
Received: 24 September 2020
Accepted after revision: 13 November 2020
Article published online:
08 January 2021
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