Synlett 2020; 31(13): 1277-1281
DOI: 10.1055/s-0040-1707138
letter
© Georg Thieme Verlag Stuttgart · New York

Site-Selective Suzuki–Miyaura Reaction of 6,8-Dichloro-1,2,4-triazolo[4,3-a]pyridines

David Kuhrt
a   Universität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
b   Leibniz Institut für Katalyse, Albert-Einstein-Str. 29a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
,
Peter Ehlers
a   Universität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
b   Leibniz Institut für Katalyse, Albert-Einstein-Str. 29a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
,
Anke Spannenberg
b   Leibniz Institut für Katalyse, Albert-Einstein-Str. 29a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
,
Peter Langer
a   Universität Rostock, Institut für Chemie, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
b   Leibniz Institut für Katalyse, Albert-Einstein-Str. 29a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
› Author Affiliations

Financial support by the federal state of Mecklenburg-Vorpommern is gratefully acknowledged.
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Publication History

Received: 09 April 2020

Accepted after revision: 10 May 2020

Publication Date:
03 June 2020 (online)


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Abstract

Triazolopyridines have found various applications as pharmaceuticals, agrochemicals, or optical materials. Consequently, the introduction of various functionalities at specific sites of this heterocyclic framework is of great importance. In this regard, we report the development of a site-selective Suzuki–Miyaura reactions leading to substituted triazolopyridines at positions 6 and 8. Under optimized conditions, the respective products have been obtained with high selectivity and yield.

Supporting Information