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Synlett 2020; 31(13): 1287-1290
DOI: 10.1055/s-0040-1707140
DOI: 10.1055/s-0040-1707140
letter
Decarboxylative Formylation of Aryl Halides with Glyoxylic Acid by Palladium Catalysis under Oxygen
We are grateful to the National Key Research and Development Program of China (2017YFB0306701), and the National Natural Science Foundation of China (NO. U1362111).Further Information
Publication History
Received: 19 April 2020
Accepted after revision: 18 May 2020
Publication Date:
18 June 2020 (online)


Abstract
A new free radical/palladium cooperative catalyzed formylation of aryl halides with glyoxylic acid as the formyl source under oxygen conditions has been developed. Various aromatic and heteroaromatic aldehydes were produced in medium to good yields.
Key words
aryl halide - reductive carbonylation - aldehydes - palladium catalysis - synthetic methodsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707140.
- Supporting Information