Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald–Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol

Joana F. Campos; Alexandra Pacheco-Benichou; Corinne Fruit; Thierry Besson; Sabine Berteina-Raboin

doi:10.1055/s-0040-1707158

Synthesis, Inhaltsverzeichnis

Synthesis 2020; 52(20): 3071-3076
DOI: 10.1055/s-0040-1707158

paper

Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald–Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol

Joana F. Campos

^aInstitut de Chimie Organique et Analytique (ICOA), Université d’Orléans UMR-CNRS 7311, BP 6759, rue de Chartres, 45067 Orléans Cedex 2, France eMail: sabine.berteina-raboin@univ-orleans.fr

,

Alexandra Pacheco-Benichou

^bNormandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France

,

Corinne Fruit

^bNormandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France

,

Thierry Besson

^bNormandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA UMR 6014, 76000 Rouen, France

,

Sabine Berteina-Raboin ∗

^aInstitut de Chimie Organique et Analytique (ICOA), Université d’Orléans UMR-CNRS 7311, BP 6759, rue de Chartres, 45067 Orléans Cedex 2, France eMail: sabine.berteina-raboin@univ-orleans.fr

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Abstract

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Abstract

The synthesis of a new library of polyheterocyclic 11H-pyrido[2,1-b]quinazolin-11-one derivatives was investigated. Satisfactory conditions were obtained via sequential C–N Buchwald–Hartwig coupling and pyridine dearomatization. In this work, traditional solvents were replaced by the bio-sourced eucalyptol, confirming the interest in it as a green solvent in chemistry.

Key words

O,S,N-heterocycles - 11H-pyrido[2,1-b]quinazolin-11-ones - Buchwald–Hartwig coupling - eucalyptol - sustainable chemistry

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Referenzen

References
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