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Synthesis 2020; 52(20): 3071-3076
DOI: 10.1055/s-0040-1707158
DOI: 10.1055/s-0040-1707158
paper
Synthesis of Benzo-Fused 11H-Pyrido[2,1-b]quinazolin-11-ones by a Buchwald–Hartwig Coupling/Pyridine Dearomatization Sequence in Eucalyptol
Financial support was provided by Région Centre-Val de Loire (J.F.C. and S.B.-R.). Région Normandie [RIN (Réseaux d’Intérêts Normands) program] is gratefully acknowledged for doctoral fellowships to A.P.-B. T.B. and C.F. thank LABEX SynOrg (ANR-11-LABX-0029).Further Information
Publication History
Received: 08 May 2020
Accepted after revision: 25 May 2020
Publication Date:
27 July 2020 (online)
Abstract
The synthesis of a new library of polyheterocyclic 11H-pyrido[2,1-b]quinazolin-11-one derivatives was investigated. Satisfactory conditions were obtained via sequential C–N Buchwald–Hartwig coupling and pyridine dearomatization. In this work, traditional solvents were replaced by the bio-sourced eucalyptol, confirming the interest in it as a green solvent in chemistry.
Key words
O,S,N-heterocycles - 11H-pyrido[2,1-b]quinazolin-11-ones - Buchwald–Hartwig coupling - eucalyptol - sustainable chemistrySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707158.
- Supporting Information
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