Integrated Synthesis of Thienyl Thioethers and Thieno[3,2-b]thiophenes via 1-Benzothiophen-3(2H)-ones

Abstract

A one-pot procedure for the synthesis of thienyl thioethers is described. Several thienyl thioethers were synthesized by a TfOH-promoted Friedel–Crafts-type cyclization, a subsequent nucleophilic attack by an arenethiol, and dehydration. This protocol was successfully applied to the synthesis of thienoacene derivatives by using a Pd-catalyzed dehydrogenative cyclization.

Key words

thienyl thioethers - thioetherification - one-pot synthesis - metal-free - halide-free - thienoacenes

Publication History

Received: 20 January 2020

Accepted after revision: 05 August 2020

Article published online:
21 September 2020

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