Synlett 2020; 31(13): 1291-1294
DOI: 10.1055/s-0040-1707893
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Two Novel Mixed Bifunctional Chelating Agents: DO2AP(tBu)4 and DO3AP(tBu)4

a   Bracco Imaging Spa, Bracco Research Centre, Via Ribes 5, 10010 Colleretto Giacosa (TO), Italy
b   Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, Largo Donegani 2/3, 28100 Novara (NO), Italy
,
Luca Biondi
a   Bracco Imaging Spa, Bracco Research Centre, Via Ribes 5, 10010 Colleretto Giacosa (TO), Italy
,
c   Bracco SpA, Innovation Hub, Via Caduti di Marcinelle 13, 20134 Milano (MI), Italy   eMail: giovannibattista.giovenzana@uniupo.it   eMail: luciano.lattuada@bracco.com
,
b   Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, Largo Donegani 2/3, 28100 Novara (NO), Italy
› Institutsangaben
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Publikationsverlauf

Received: 22. März 2020

Accepted after revision: 08. Mai 2020

Publikationsdatum:
16. Juni 2020 (online)


Abstract

A convenient synthesis of two novel macrocyclic bifunctional chelating agents (BFCAs), formally derived from the well-known ligands DO3A and DOTA by selective replacement of one carboxymethyl side arm with a phosphonomethyl residue, is reported.

Supporting Information