Efficacy of Allicin on DMBA-Induced BRCA-1 Defective Breast Carcinoma in Wistar Rats

Carcinoma of the breast is a type of malignant growth which is developed from the tissue of the breast. The study was aiming to assess the effectiveness of (allicin) on dimethylbenz[a]anthracene (DMBA)-induced mammary carcinomas. There were no significant differences in the weight of the experimental animals. DMBA only, Allicin only or the combination of Allicin and DMBA low concentration group showed that tumor is present in the mammary rats, while group A, D, E and F showed no breast tumor at the end of the study. There is existence of proliferation as regards ductal epithelial cells as well as the tissue reaction within mammalian concerning the animal induced with DMBA only. DNA band which was secured in the midst of gel electrophoresis propose that DMBA instigated impairment which occurred at certain degree. This study has shown that allicin could be used as a chemo-preventive agent against DMBA mammary carcinoma at the lowest concentration of allicin.

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Artikel online veröffentlicht:
13. Mai 2020