DOI : 10.1055/s-00000034

Klinische Pädiatrie

Issue 03 · Volume 232 · May 2020 DOI: 10.1055/s-010-48434


33. Jahrestagung der Kind-Philipp-Stiftung für pädiatr. onkolog. Forschung
Wilsede, 27.03.2020

Prof. Marschalek
Abstracts (HTML) Abstracts (PDF) List of Authors
  • Malouf, C; Sahm, F; Landua, SL; Halsey, C; Ottersbach, K:

    miR-128a and miR-130b determine lineage choice and leukemia-propagating cell identity in MLL-AF4+ acute leukemia

  • Antunes, E; Ottersbach, K:

    Identification of the cell of origin in infant MLL-AF9 leukaemia

  • Siemund, A; Kowarz, E; Marschalek, R:

    Small changes in the MLL-AF4 fusion protein make a difference

  • Wilhelm, A; Marschalek, R:

    Role of reciprocal fusions in MLL-r acute leukemia: studying t(4;11) fusion proteins

  • Kundu, A; Kowarz, E; Marschalek, R:

    The role of reciprocal fusions in MLL-r acute leukemia: studying t(6;11) fusion proteins

  • Gasparoli, L; Virely, C; Cantilena, S; Bartram, J; Inglott, S; De Boer, J; Williams, O:

    Deciphering STAT3 dependency in paediatric acute lymphoblastic leukemia

  • Lenk, L; Carlet, M; Cousins, A; Cario, G; Halsey, C; Jeremias, I; Hobeika, E; Jumaa, H; Alsadeq, A; Schewe, DM:

    CD79a/CD79b Promote CNS-Involvement and Leukemic Engraftment in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia

  • Rademacher, AV; Schewe, DM; Bergh, B; Frielitz, FS:

    Efficient healthcare for children with cancer using telemedicine in intensive chemotherapy phases

  • Barwinski, N; Zeschnigk, M; Thakur, BK; Lohmann, D; Ketteler, P:

    cf-DNA and EVs: Biomarkers for early detection of second primary malignancies in patients with heritable retinoblastoma

  • Minari, JB; Salaudeen, BO; Adebiyi, FD:

    Efficacy of Allicin on DMBA-Induced BRCA-1 Defective Breast Carcinoma in Wistar Rats

  • Müller, K; Vogiatzi, F; Winterberg, D; Rösner, T; Cario, G; Schrappe, M; Peipp, M; Valerius, T; Kellner, C; Schewe, DM:

    Immunotherapeutic co-targeting of CD38 and CD47 in T-cell acute lymphoblastic leukemia (T-ALL)

  • Bhatia, S; Ahlert, H; Dienstbier, N; Schliehe-Diecks, J; Sönnichsen, M; Remke, M; Fischer, U; Hauer, J; Borkhardt, A:

    Therapeutic stratification of acute leukemia using high throughput drug screening

  • Szoltysek, K; Blair, H; Tirtakusuma, R; Nakjang, S; Law, E; McKenzie, L; Vormoor, J; Pal, D; Heidenreich, O:

    Whole-genome CRISPR screen as a tool to identify mechanism of relapse and potential targets for novel drug combinations

  • Swart, LE; Issa, H; Blair, H; Heidenreich, O:

    Specific targeting of RUNX1/ETO; delivery of siRNA using Lipid Nanoparticles in vitro and in vivo

  • Niedermayer, A; Enzenmüller, S; Tausch, E; Stilgenbauer, S; Seyfried, F; Meyer, LH:

    Characterization of mechanisms of acquired Venetoclax-insensitivity in B-cell precursor acute lymphoblastic leukemia

  • Boldrin, E; Gaffo, E; Boer, JM; Claus, R; Plass, C; Den Boer, ML; Debatin, KM; Te Kronnie, G; Bortoluzzi, S; Meyer, LH:

    MicroRNA - 497~195 cluster suppresses cell cycle progression by targeting CCND3/CDK4 in acute lymphoblastic leukemia

  • Helmsauer, K; Valieva, M; Ali, S; Chamorro Gonzalez, R; Schöpflin, R; Schulte, JH; Mundlos, S; Koche, RP; Henssen, AG:

    Enhancer hijacking on the MYCN amplicon in neuroblastoma

  • Mir-Salim, D; Bhayadia, R; Heckl, D; Klusmann, JH:

    Testing ABT-263 for the treatment of pediatric acute myeloid leukemia

  • Werr, LH; Ackermann, J; Kahlert, Y; Fischer, J; Wunderlich, FT; Fischer, M:

    Investigating the role of activated telomerase in genetically engineered neuroblastoma mouse models

  • Diskowski, L; Kubiak, K; Wiese, M; Kramm, CM:

    The function of CBP/p300 and BET-proteins in dependence of H3.3K27M mutation in diffuse intrinsic pontine glioma (DIPG)

  • Weigert, K; Alejo-Valle, O; Labuhn, M; Amstislavskiy, V; Emmrich, S; Ng, M; Yaspo, ML; Heckl, D; Klusmann, JH:

    Investigating miR-125b target gene Arid3a in trisomy 21-associated leukemogenesis

  • Zastrow, J; Wiese, M; Kramm, CM:

    Comparison of Curcumin and Curcuminoids in terms of mechanisms of action and treatment efficiency in DIPG

  • Singh, M; Blair, H; Berry, P; Heidenreich, O:

    Multi-drug chemotherapy dose optimisation in preclinical leukaemia models using HPLC-MS/MS

  • Ng, M; Bhayadia, R; Regenyi, E; Amstislavskiy, V; Yaspo, ML; Heckl, D; Klusmann, JH:

    CRISPR/Cas9-based screens identify an essential long noncoding RNA locus in pediatric acute myeloid leukemia cells

  • Ehl, C; Bräuer-Hartmann, D; Gialesaki, S; Alejo-Valle, O; Issa, H; Regenyi, E; Yaspo, ML; Heckl, D; Klusmann, JH:

    Mapping chromatin occupancy of GATA1 and RUNX1 isoforms in Down syndrome myeloid leukemia

  • Huynh, AKD; Walch-Rückheim, B; Smola, S; Graf, N:

    Combined infection with oncolytic viruses (OVs) induces synergistic and additive cell death in glioblastoma multiforme (GBM) cell lines

  • Law, EW; McKenzie, L; Blair, H; Bulmer, D; Pal, D; Szoltysek, K; Lunec, J; Irving, J; Vormoor, J:

    High-throughput imaging analysis for drug combination efficacy in childhood acute lymphoblastic leukaemia

  • Rajak, J; Wu, Y; Koleci, N; Niemeyer, CM; Erlacher, M:

    Identification of novel therapeutic approaches in a xenograft model of juvenile myelomonocytic leukemia (JMML)

  • Miroshnichenkova, A; Komkov, A; Volchkov, E; Popov, A; Maschan, M; Mamedov, I; Olshanskaya, Y:

    High-throughput sequencing of Ig/TCR genes for MRD monitoring in B-ALL patients receiving immunotherapy

  • Grimm, J; Bhayadia, R; Heckl, D; Klusmann, JH:

    Overcoming differentiation blockage by inhibition of LSD1 as novel therapeutic strategy in pediatric AML

  • Komkov, A; Miroshnichenkova, A; Smirnova, A; Komech, E; Atapina, E; Popov, A; Lebedev, Y; Maschan, M; Olshanskaya, Y; Mamedov, I:

    A cost-effective quasi single-cell assay for deciphering of clonal architecture of leukemic cells

  • Schuschel, K; Helwig, M; Regényi, E; Yaspo, ML; Heckl, D; Klusmann, JH; Hoell, JI:

    Characterization of RNA-Protein Interaction Networks in Acute Leukemias

  • Volz, C; Gottschalk, A; Krumbholz, M; Albert, C; Semper, S; Suttorp, M; Glauche, I; Metzler, M:

    Therapy assessment of pediatric chronic myeloid leukemia (CML) using combined analyses of RNA/DNA response dynamics

  • Schneider, D; Schwarzer, A; Knoess, S; Matzk, S; Amstislavskiy, V; Warnatz, HJ; Jian, Xu; Yaspo, ML; Klusmann, JH; Heckl, D:

    Ezh2 loss cooperates with loss of Runx1 during leukemogenesis and reactivates a fetal gene signature

  • Issa, H; Heckl, D; Klusmann, JH:

    Rewiring the interplay between GATA1s and secondary mutations in the leukaemogenic transformation

  • Blunck, CB; Poubel, CP; Lopes, BA; Mansur, MB; Emerenciano, M:

    Identification of cellular markers for the IKZF1plus subgroup of B-cell acute lymphoblastic leukemia

  • Zeuner, S; Ecker, J; Vollmer, J; Oppermann, S; Oehme, I; Peterziel, H; ElHarouni, D; Hielscher, T; Witt, O; Milde, T:

    Enhancing the effect of class I HDAC inhibition in MYC amplified group 3 medulloblastoma with novel drug combinations

  • von Stebut, J; Bardinet, V; Dorado Garcia, H; Bei, Y; Haase, K; Henssen, A:

    Genome-wide CRISPRa screen identifies determinants of Actinomycin-D resistance in alveolar rhabdomyosarcoma