Case Report: Intrahepatic Cholestasis of Pregnancy

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by pruritus, elevated serum aminotransferases and bile acid levels with gradual onset in the second or third trimester of pregnancy, and spontaneous relief of signs and symptoms within two to three weeks after delivery.

Keywords

Intrahepatic Cholestasis(ICP) - Pruritis - Bile Acid

• References

• 1 Magdalena Paunescu, Mugurel G. Paunescu, Virgil Feier. Intrahepatic Cholestasis of Pregnancy: A Review of Epidemiology, Clinical Features, Fetal Risks, Treatment, and Management. Timosora Medical Journal. Nov 4, 2007
• 2 Thomas Pusl, Ulrich Beuers, Intrahepatic cholestasis of pregnancy: Orphanet Journal of Rare Diseases 2007, 2:26
• 3 Poupon R: Intrahepatic cholestasis of pregnancy: from bedside to bench to bedside. Liver Int 2005, 25:467-68
• 4 Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA.Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in pat ient s wi th int rahepat ic cholestas i s of pregnancy. Pharmacogenetics: 2004, 14:91-102.
• 5 Jacquemin E, Cresteil D, Manouvrier S, Boute O, Hadchouel M: Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy: Lancet 1999, 353:210-11.
• 6 Sangita Ghosh, Soumik Chaudhuri, Intra-hepatic Cholestasis of Pregnancy: A Comprehensive Review,Indian J Dermatol. 2013 Jul-Aug; 58(4):327
• 7 Anne Davit-Spraul, Emmanuel Gonzales, Christiane Baussan, Emmanuel Jacquemin, Progressive familial intrahepatic cholestasis. Orphanet Journal of Rare Diseases 2009, 4:1