English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis^[1]

Abstract

Chronic pancreatitis is a disease of the pancreas in which recurrent inflammatory episodes result in replacement of pancreatic parenchyma by fibrous connective tissue. This fibrotic reorganisation of the pancreas leads to a progressive exocrine and endocrine pancreatic insufficiency. In addition, characteristic complications arise, such as pseudocysts, pancreatic duct obstructions, duodenal obstruction, vascular complications, obstruction of the bile ducts, malnutrition and pain syndrome. Pain presents as the main symptom of patients with chronic pancreatitis. Chronic pancreatitis is a risk factor for pancreatic carcinoma. Chronic pancreatitis significantly reduces the quality of life and the life expectancy of affected patients. These guidelines were researched and compiled by 74 representatives from 11 learned societies and their intention is to serve evidence-based professional training as well as continuing education. On this basis they shall improve the medical care of affected patients in both the inpatient and outpatient sector. Chronic pancreatitis requires an adequate diagnostic workup and systematic management, given its severity, frequency, chronicity, and negative impact on the quality of life and life expectancy.

Zusammenfassung

Die chronische Pankreatitis ist eine Erkrankung der Bauchspeicheldrüse, bei der rezidivierende Entzündungsschübe zu einem Ersatz des Pankreasparenchyms durch narbiges Bindegewebe führen. Diese Narbenbildung des Pankreas führt zu einem fortschreitenden Verlust der exokrinen und endokrinen Pankreasfunktion. Darüber hinaus treten typische Komplikationen auf zu denen die Bildung von Pseudozysten, Stenosen im Pankreasgang, Obstruktionen des Zwölffingerdarms, Gefäßkomplikationen, einer Obstruktion des Gallengangs, eine Mangel- und Fehlernährung sowie ein Schmerzsyndrom gehören. Das wichtigste Symptom der chronischen Pankreatitis sind abdominelle Schmerzen. Die chronische Pankreatitis stellt einen Risikofaktor für die Entstehung des Pankreaskarzinoms dar. Die chronische Pankreatitis reduziert sowohl die Lebensqualität als auch die Lebenserwartung betroffener Patienten deutlich. Die hier vorgelegte Leitlinie wurde von 74 Vertretern aus 11 Fachgesellschaften als Basis für eine evidenzbasierte Fort- und Weiterbildung zusammengestellt. Ihr Ziel ist es, die medizinische Versorgung betroffener Patienten sowohl im ambulanten als auch im stationären Bereich zu verbessern. Wegen ihrer Krankheitsschwere, ihrer Häufigkeit, ihres chronischen Verlaufs und ihres deutlich negativen Einflusses auf die Lebensqualität und die Lebenserwartung, bedürfen Patienten mit chronischer Pankreatitis einer angemessenen Diagnostik und systematischen Therapie.

Key words

pancreas - chronic pancreatitis - guideline

Schlüsselwörter

pankreas - chronische Pankreatitis - leitlinie

¹ Guidelines of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS)

¹ In co-operation with the German Society of Internal Medicine (DGIM), German Association of Private-practice Gastroenterologists (bng), Society for Paediatric Gastroenterology and Nutrition (GPGE), German Society for Nutritional Medicine (DGEM), German Society of General and Visceral Surgery (DGAV), Austrian Society for Gastroenterology and Hepatology (ÖGGH), Swiss Society of Gastroenterology (SGG), Swiss Society of Visceral Surgery (SGVC), German Radiology Society, German Pancreas Aid, Working Group of Pancreatectomy Patients, German Society for Pathology (DGP) (DRG).

^* Equally contributing first author.

^** Equally contributing senior author.

• References

• 1 Dufour MC, Adamson MD. The epidemiology of alcohol-induced pancreatitis. Pancreas 2003; 27: 286-290
• 2 Ammann RW, Akovbiantz A, Largiader F. et al. Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology 1984; 86: 820-828
• 3 Miyake H, Harada H, Kunichika K. et al. Clinical course and prognosis of chronic pancreatitis. Pancreas 1987; 2: 378-385
• 4 Lankisch PG, Lohr-Happe A, Otto J. et al. Natural course in chronic pancreatitis. Pain, exocrine and endocrine pancreatic insufficiency and prognosis of the disease. Digestion 1993; 54: 148-155
• 5 Gastard J, Joubaud F, Farbos T. et al. Etiology and course of primary chronic pancreatitis in Western France. Digestion 1973; 9: 416-428
• 6 Lowenfels AB, Maisonneuve P, Cavallini G. et al. Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group. Am J Gastroenterol 1994; 89: 1467-1471
• 7 Maisonneuve P, Lowenfels AB, Mullhaupt B. et al. Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. Gut 2005; 54: 510-514
• 8 van Geenen EJ, Smits MM, Schreuder TC. et al. Smoking is related to pancreatic fibrosis in humans. Am J Gastroenterol 2011; 106: 1161-1166; quiz 1167
• 9 Mossner J, Keim V, Niederau C. et al. Guidelines for therapy of chronic pancreatitis. Consensus Conference of the German Society of Digestive and Metabolic Diseases. Halle 21-23 November 1996. Z Gastroenterol 1998; 36: 359-367
• 10 Durbec JP, Sarles H. Multicenter survey of the etiology of pancreatic diseases. Relationship between the relative risk of developing chronic pancreaitis and alcohol, protein and lipid consumption. Digestion 1978; 18: 337-350
• 11 Johnson CD, Hosking S. National statistics for diet, alcohol consumption, and chronic pancreatitis in England and Wales, 1960-88. Gut 1991; 32: 1401-1405
• 12 Lin Y, Tamakoshi A, Hayakawa T. et al. Associations of alcohol drinking and nutrient intake with chronic pancreatitis: findings from a case-control study in Japan. Am J Gastroenterol 2001; 96: 2622-2627
• 13 Maruyama K, Otsuki M. Incidence of alcoholic pancreatitis in Japanese alcoholics: survey of male sobriety association members in Japan. Pancreas 2007; 34: 63-65
• 14 Sarles H, Cros RC, Bidart JM. A multicenter inquiry into the etiology of pancreatic diseases. Digestion 1979; 19: 110-125
• 15 Stigendal L, Olsson R. Alcohol consumption pattern and serum lipids in alcoholic cirrhosis and pancreatitis. A comparative study. Scand J Gastroenterol 1984; 19: 582-587
• 16 Talamini G, Bassi C, Falconi M. et al. Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer. Dig Dis Sci 1999; 44: 1303-1311
• 17 Levy P, Mathurin P, Roqueplo A. et al. A multidimensional case-control study of dietary, alcohol, and tobacco habits in alcoholic men with chronic pancreatitis. Pancreas 1995; 10: 231-238
• 18 Suda K, Shiotsu H, Nakamura T. et al. Pancreatic fibrosis in patients with chronic alcohol abuse: correlation with alcoholic pancreatitis. Am J Gastroenterol 1994; 89: 2060-2062
• 19 UK guidelines for the management of acute pancreatitis. Gut 2005; 54 (Suppl. 03) iii1-9
• 20 Bakker OJ, van Santvoort HC, Hagenaars JC. et al. Timing of cholecystectomy after mild biliary pancreatitis. Br J Surg 2011; 98: 1446-1454
• 21 Yan MX, Li YQ. Gall stones and chronic pancreatitis: the black box in between. Postgrad Med J 2006; 82: 254-258
• 22 Garg PK, Tandon RK. Survey on chronic pancreatitis in the Asia-Pacific region. J Gastroenterol Hepatol 2004; 19: 998-1004
• 23 Jacob JJ, John M, Thomas N. et al. Does hyperparathyroidism cause pancreatitis? A South Indian experience and a review of published work. ANZ J Surg 2006; 76: 740-744
• 24 Carnaille B, Oudar C, Pattou F. et al. Pancreatitis and primary hyperparathyroidism: forty cases. Aust N Z J Surg 1998; 68: 117-119
• 25 Talamini G, Falconi M, Bassi C. et al. Previous cholecystectomy, gastrectomy, and diabetes mellitus are not crucial risk factors for pancreatic cancer in patients with chronic pancreatitis. Pancreas 2001; 23: 364-367
• 26 Burtin P, Person B, Charneau J. et al. Pancreas divisum and pancreatitis: a coincidental association?. Endoscopy 1991; 23: 55-58
• 27 Kamisawa T, Tu Y, Egawa N. et al. Clinical implications of incomplete pancreas divisum. JOP 2006; 7: 625-630
• 28 Kim MH, Lee SS, Kim CD. et al. Incomplete pancreas divisum: is it merely a normal anatomic variant without clinical implications?. Endoscopy 2001; 33: 778-785
• 29 Spicak J, Poulova P, Plucnarova J. et al. Pancreas divisum does not modify the natural course of chronic pancreatitis. J Gastroenterol 2007; 42: 135-139
• 30 Su WJ, Chen HL, Lai HS. et al. Pancreaticobiliary anomalies is the leading cause of childhood recurrent pancreatitis. J Formos Med Assoc 2007; 106: 119-125
• 31 Yatto RP, Siegel JH. The role of pancreatobiliary duct anatomy in the etiology of alcoholic pancreatitis. J Clin Gastroenterol 1984; 6: 419-423
• 32 Agha FP, Williams KD. Pancreas divisum: incidence, detection, and clinical significance. Am J Gastroenterol 1987; 82: 315-320
• 33 Dhar A, Goenka MK, Kochhar R. et al. Pancrease divisum: five years' experience in a teaching hospital. Indian J Gastroenterol 1996; 15: 7-9
• 34 Quest L, Lombard M. Pancreas divisum: opinio divisa. Gut 2000; 47: 317-319
• 35 Buhler H, Seefeld U, Deyhle P. et al. [Clinical significance of pancreas divisum]. Schweiz Med Wochenschr 1983; 113: 320-324
• 36 Akatsu T, Aiura K, Takahashi S. et al. Recurrent pancreatitis caused by ampullary carcinoma and minor papilla adenoma in familial polyposis: report of a case. Surg Today 2008; 38: 440-444
• 37 Maisonneuve P, Frulloni L, Mullhaupt B. et al. Impact of smoking on patients with idiopathic chronic pancreatitis. Pancreas 2006; 33: 163-168
• 38 Yadav D, Hawes RH, Brand RE. et al. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis. Arch Intern Med 2009; 169: 1035-1045
• 39 Ammann RW, Knoblauch M, Mohr P. et al. High incidence of extrapancreatic carcinoma in chronic pancreatitis. Scand J Gastroenterol 1980; 15: 395-399
• 40 Ammann RW, Muellhaupt B. The natural history of pain in alcoholic chronic pancreatitis. Gastroenterology 1999; 116: 1132-1140
• 41 Cavallini G, Talamini G, Vaona B. et al. Effect of alcohol and smoking on pancreatic lithogenesis in the course of chronic pancreatitis. Pancreas 1994; 9: 42-46
• 42 Talamini G, Bassi C, Falconi M. et al. Pain relapses in the first 10 years of chronic pancreatitis. Am J Surg 1996; 171: 565-569
• 43 Whitcomb DC, Gorry MC, Preston RA. et al. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996; 14: 141-145
• 44 Whitcomb DC, Preston RA, Aston CE. et al. A gene for hereditary pancreatitis maps to chromosome 7q35. Gastroenterology 1996; 110: 1975-1980
• 45 Howes N, Lerch MM, Greenhalf W. et al. Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin Gastroenterol Hepatol 2004; 2: 252-261
• 46 Applebaum-Shapiro SE, Finch R, Pfutzer RH. et al. Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study. Pancreatology 2001; 1: 439-443
• 47 Simon P, Weiss FU, Sahin-Toth M. et al. Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 → Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem 2002; 277: 5404-5410
• 48 Rebours V, Boutron-Ruault MC, Jooste V. et al. Mortality rate and risk factors in patients with hereditary pancreatitis: uni- and multidimensional analyses. Am J Gastroenterol 2009; 104: 2312-2317
• 49 Rebours V, Boutron-Ruault MC, Schnee M. et al. The natural history of hereditary pancreatitis: a national series. Gut 2009; 58: 97-103
• 50 Elitsur Y, Chertow BC, Jewell RD. et al. Identification of a hereditary pancreatitis mutation in four West Virginia families. Pediatr Res 1998; 44: 927-930
• 51 Le Bodic L, Bignon JD, Raguenes O. et al. The hereditary pancreatitis gene maps to long arm of chromosome 7. Hum Mol Genet 1996; 5: 549-554
• 52 Le Bodic L, Schnee M, Georgelin T. et al. An exceptional genealogy for hereditary chronic pancreatitis. Dig Dis Sci 1996; 41: 1504-1510
• 53 Aoun E, Chang CC, Greer JB. et al. Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis. PLoS One 2008; 3: e2003
• 54 Witt H, Luck W, Hennies HC. et al. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 2000; 25: 213-216
• 55 Durno C, Corey M, Zielenski J. et al. Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis. Gastroenterology 2002; 123: 1857-1864
• 56 Cohn JA, Neoptolemos JP, Feng J. et al. Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers. Hum Mutat 2005; 26: 303-307
• 57 Choudari CP, Imperiale TF, Sherman S. et al. Risk of pancreatitis with mutation of the cystic fibrosis gene. Am J Gastroenterol 2004; 99: 1358-1363
• 58 Sharer N, Schwarz M, Malone G. et al. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998; 339: 645-652
• 59 Weiss FU, Simon P, Bogdanova N. et al. Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls. Gut 2005; 54: 1456-1460
• 60 De Boeck K, Weren M, Proesmans M. et al. Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype. Pediatrics 2005; 115: e463-469
• 61 Rosendahl J, Witt H, Szmola R. et al. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. Nat Genet 2008; 40: 78-82
• 62 Masson E, Chen JM, Scotet V. et al. Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. Hum Genet 2008; 123: 83-91
• 63 Masson E, Le MarechalC, Delcenserie R. et al. Hereditary pancreatitis caused by a double gain-of-function trypsinogen mutation. Hum Genet 2008; 123: 521-529
• 64 Chang MC, Chang YT, Wei SC. et al. Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan. Pancreatology 2009; 9: 287-292
• 65 Sarles H, Sarles JC, Muratore R. et al. Chronic inflammatory sclerosis of the pancreas--an autonomous pancreatic disease?. Am J Dig Dis 1961; 6: 688-698
• 66 Yoshida K, Toki F, Takeuchi T. et al. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci 1995; 40: 1561-1568
• 67 Kamisawa T, Chari ST, Giday SA. et al. Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey. Pancreas 40: 809-814
• 68 Chari ST, Smyrk TC, Levy MJ. et al. Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience. Clin Gastroenterol Hepatol 2006; 4: 1010-1016; quiz 1934
• 69 Kamisawa T, Egawa N, Nakajima H. et al. Clinical difficulties in the differentiation of autoimmune pancreatitis and pancreatic carcinoma. Am J Gastroenterol 2003; 98: 2694-2699
• 70 Chari ST, Kloeppel G, Zhang L. et al. Histopathologic and clinical subtypes of autoimmune pancreatitis: the Honolulu consensus document. Pancreas 39: 549-554
• 71 Frulloni L, Gabbrielli A, Pezzilli R. et al. Chronic pancreatitis: report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis 2009; 41: 311-317
• 72 Lankisch PG, Assmus C, Maisonneuve P. et al. Epidemiology of pancreatic diseases in Luneburg County. A study in a defined german population. Pancreatology 2002; 2: 469-477
• 73 Levy P, Barthet M, Mollard BR. et al. Estimation of the prevalence and incidence of chronic pancreatitis and its complications. Gastroenterol Clin Biol 2006; 30: 838-844
• 74 Kloppel G, Sipos B, Zamboni G. et al. Autoimmune pancreatitis: histo- and immunopathological features. J Gastroenterol 2007; 42 (Suppl. 18) 28-31
• 75 Church NI, Pereira SP, Deheragoda MG. et al. Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series. Am J Gastroenterol 2007; 102: 2417-2425
• 76 Deheragoda MG, Church NI, Rodriguez-Justo M. et al. The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis. Clin Gastroenterol Hepatol 2007; 5: 1229-1234
• 77 Okazaki K, Kawa S, Kamisawa T. et al. Japanese clinical guidelines for autoimmune pancreatitis. Pancreas 2009; 38: 849-866
• 78 Kamisawa T, Shimosegawa T, Okazaki K. et al. Standard steroid treatment for autoimmune pancreatitis. Gut 2009; 58: 1504-1507
• 79 Comfort MW, Steinberg AG. Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology 1952; 21: 54-63
• 80 Lowenfels AB, Maisonneuve P, Whitcomb DC. et al. Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis. JAMA 2001; 286: 169-170
• 81 Ellis I, Lerch MM, Whitcomb DC. Genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues. Pancreatology 2001; 1: 405-415
• 82 Rebours V, Boutron-Ruault MC, Schnee M. et al. Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. Am J Gastroenterol 2008; 103: 111-119
• 83 Löhr J. Exokrine Pankreasinsuffizienz. 3rd Edition. Bremen: UNI-MED Verlag; 2010
• 84 Layer P, Holtmann G. Pancreatic enzymes in chronic pancreatitis. Int J Pancreatol 1994; 15: 1-11
• 85 DiMagno EP, Go VL, Summerskill WH. Relations between pancreatic enzyme ouputs and malabsorption in severe pancreatic insufficiency. N Engl J Med 1973; 288: 813-815
• 86 DiMagno EP, Malagelada JR, Go VL. et al. Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules. N Engl J Med 1977; 296: 1318-1322
• 87 Lankisch PG, Seidensticker F, Otto J. et al. Secretin-pancreozymin test (SPT) and endoscopic retrograde cholangiopancreatography (ERCP): both are necessary for diagnosing or excluding chronic pancreatitis. Pancreas 1996; 12: 149-152
• 88 Lankisch PG, Droge M, Hofses S. et al. Steatorrhoea: you cannot trust your eyes when it comes to diagnosis. Lancet 1996; 347: 1620-1621
• 89 Dumasy V, Delhaye M, Cotton F. et al. Fat malabsorption screening in chronic pancreatitis. Am J Gastroenterol 2004; 99: 1350-1354
• 90 Meier R, Ockenga J, Pertkiewicz M. et al. ESPEN Guidelines on Enteral Nutrition: Pancreas. Clin Nutr 2006; 25: 275-284
• 91 Haaber AB, Rosenfalck AM, Hansen B. et al. Bone mineral metabolism, bone mineral density, and body composition in patients with chronic pancreatitis and pancreatic exocrine insufficiency. Int J Pancreatol 2000; 27: 21-27
• 92 Kalvaria I, Labadarios D, Shephard GS. et al. Biochemical vitamin E deficiency in chronic pancreatitis. Int J Pancreatol 1986; 1: 119-128
• 93 Mann ST, Stracke H, Lange U. et al. Vitamin D3 in patients with various grades of chronic pancreatitis, according to morphological and functional criteria of the pancreas. Dig Dis Sci 2003; 48: 533-538
• 94 Mann ST, Mann V, Stracke H. et al. Fecal elastase 1 and vitamin D3 in patients with osteoporotic bone fractures. Eur J Med Res 2008; 13: 68-72
• 95 Bozkurt T, Braun U, Leferink S. et al. Comparison of pancreatic morphology and exocrine functional impairment in patients with chronic pancreatitis. Gut 1994; 35: 1132-1136
• 96 Chowdhury RS, Forsmark CE. Review article: Pancreatic function testing. Aliment Pharmacol Ther 2003; 17: 733-750
• 97 Chowdhury R, Bhutani MS, Mishra G. et al. Comparative analysis of direct pancreatic function testing versus morphological assessment by endoscopic ultrasonography for the evaluation of chronic unexplained abdominal pain of presumed pancreatic origin. Pancreas 2005; 31: 63-68
• 98 Stevens T, Lopez R, Adler DG. et al. Multicenter comparison of the interobserver agreement of standard EUS scoring and Rosemont classification scoring for diagnosis of chronic pancreatitis. Gastrointest Endosc 71: 519-526
• 99 Conwell DL, Zuccaro G, Purich E. et al. Comparison of endoscopic ultrasound chronic pancreatitis criteria to the endoscopic secretin-stimulated pancreatic function test. Dig Dis Sci 2007; 52: 1206-1210
• 100 Conwell DL, Zuccaro G, Purich E. et al. Comparison of endoscopic ultrasound chronic pancreatitis criteria to the endoscopic secretin-stimulated pancreatic function test. Dig Dis Sci 2007; 52: 1206-1210
• 101 Conwell DL, Zuccaro Jr G, Vargo JJ. et al. Comparison of the secretin stimulated endoscopic pancreatic function test to retrograde pancreatogram. Dig Dis Sci 2007; 52: 1076-1081
• 102 Albashir S, Bronner MP, Parsi MA. et al. Endoscopic ultrasound, secretin endoscopic pancreatic function test, and histology: correlation in chronic pancreatitis. Am J Gastroenterol 105: 2498-2503
• 103 Bali MA, Sztantics A, Metens T. et al. Quantification of pancreatic exocrine function with secretin-enhanced magnetic resonance cholangiopancreatography: normal values and short-term effects of pancreatic duct drainage procedures in chronic pancreatitis. Initial results. Eur Radiol 2005; 15: 2110-2121
• 104 Bali MA, Golstein P, Deviere J. et al. Evaluation of somatostatin inhibitory effect on pancreatic exocrine function using secretin-enhanced dynamic magnetic resonance cholangiopancreatography: a crossover, randomized, double blind, placebo-controlled study. Pancreas 2006; 32: 346-350
• 105 Donati F, Boraschi P, Gigoni R. et al. Secretin-stimulated MR cholangio-pancreatography in the evaluation of asymptomatic patients with non-specific pancreatic hyperenzymemia. Eur J Radiol 75: e38-e44
• 106 Siegmund E, Lohr JM, Schuff-Werner P. The diagnostic validity of non-invasive pancreatic function tests--a meta-analysis. Z Gastroenterol 2004; 42: 1117-1128
• 107 Rathmann W, Haastert B, Icks A. et al. High prevalence of undiagnosed diabetes mellitus in Southern Germany: target populations for efficient screening. The KORA survey 2000. Diabetologia 2003; 46: 182-189
• 108 Hardt PD, Hauenschild A, Jaeger C. et al. High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. Dig Dis Sci 2003; 48: 1688-1692
• 109 Hardt PD, Hauenschild A, Nalop J. et al. The commercially available ELISA for pancreatic elastase 1 based on polyclonal antibodies does measure an as yet unknown antigen different from purified elastase 1. Binding studies and clinical use in patients with exocrine pancreatic insufficiency. Z Gastroenterol 2003; 41: 903-906
• 110 Ewald N, Bretzel RG, Fantus IG. et al. Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial. Diabetes Metab Res Rev 2007; 23: 386-391
• 111 Creutzfeldt W, Arnold R. Somatostatin and the stomach: exocrine and endocrine aspects. Metabolism 1978; 27: 1309-1315
• 112 Lohr M, Kloppel G. Pathology of the pancreas in chronic type 1 diabetes mellitus: B-cell content, exocrine atrophy and angiopathy. Verh Dtsch Ges Pathol 1987; 71: 114-119
• 113 Catalano MF, Sahai A, Levy M. et al. EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest Endosc 2009; 69: 1251-1261
• 114 Catalano MF, Lahoti S, Geenen JE. et al. Prospective evaluation of endoscopic ultrasonography, endoscopic retrograde pancreatography, and secretin test in the diagnosis of chronic pancreatitis. Gastrointest Endosc 1998; 48: 11-17
• 115 Catalano MF, Geenen JE. Diagnosis of chronic pancreatitis by endoscopic ultrasonography. Endoscopy 1998; 30 (Suppl. 01) A111-A115
• 116 Chong AK, Hawes RH, Hoffman BJ. et al. Diagnostic performance of EUS for chronic pancreatitis: a comparison with histopathology. Gastrointest Endosc 2007; 65: 808-814
• 117 Nattermann C, Goldschmidt AJ, Dancygier H. Endosonography in chronic pancreatitis. A comparative study of endoscopic retrograde pancreatography and endoscopic sonography. Ultraschall Med 1992; 13: 263-270
• 118 Nattermann C, Goldschmidt AJ, Dancygier H. Endosonography in chronic pancreatitis--a comparison between endoscopic retrograde pancreatography and endoscopic ultrasonography. Endoscopy 1993; 25: 565-570
• 119 Pungpapong S, Wallace MB, Woodward TA. et al. Accuracy of endoscopic ultrasonography and magnetic resonance cholangiopancreatography for the diagnosis of chronic pancreatitis: a prospective comparison study. J Clin Gastroenterol 2007; 41: 88-93
• 120 Wiersema MJ, Hawes RH, Lehman GA. et al. Prospective evaluation of endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in patients with chronic abdominal pain of suspected pancreatic origin. Endoscopy 1993; 25: 555-564
• 121 Tamura R, Ishibashi T, Takahashi S. Chronic pancreatitis: MRCP versus ERCP for quantitative caliber measurement and qualitative evaluation. Radiology 2006; 238: 920-928
• 122 Testoni PA, Mariani A, Curioni S. et al. MRCP-secretin test-guided management of idiopathic recurrent pancreatitis: long-term outcomes. Gastrointest Endosc 2008; 67: 1028-1034
• 123 Adamek HE, Albert J, Breer H. et al. Pancreatic cancer detection with magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography: a prospective controlled study. Lancet 2000; 356: 190-193
• 124 Buscail L, Escourrou J, Moreau J. et al. Endoscopic ultrasonography in chronic pancreatitis: a comparative prospective study with conventional ultrasonography, computed tomography, and ERCP. Pancreas 1995; 10: 251-257
• 125 Stevens T, Conwell DL, Zuccaro GJr. et al. A prospective crossover study comparing secretin-stimulated endoscopic and Dreiling tube pancreatic function testing in patients evaluated for chronic pancreatitis. Gastrointest Endosc 2008; 67: 458-466
• 126 Stevens T, Conwell DL, Zuccaro Jr G. et al. Comparison of endoscopic ultrasound and endoscopic retrograde pancreatography for the prediction of pancreatic exocrine insufficiency. Dig Dis Sci 2008; 53: 1146-1151
• 127 Stevens T, Zuccaro Jr G. et al. Prospective comparison of radial and linear endoscopic ultrasound for diagnosis of chronic pancreatitis. Endoscopy 2009; 41: 836-841
• 128 Glasbrenner B, Kahl S, Malfertheiner P. Modern diagnostics of chronic pancreatitis. Eur J Gastroenterol Hepatol 2002; 14: 935-941
• 129 Hollerbach S, Ruser J, Ochs A. et al. Current status of abdominal pancreatic ultrasound. A retrospective analysis of 585 pancreatic ultrasound examinations. Med Klin (Munich) 1994; 89: 7-13
• 130 Kahl S, Glasbrenner B, Leodolter A. et al. EUS in the diagnosis of early chronic pancreatitis: a prospective follow-up study. Gastrointest Endosc 2002; 55: 507-511
• 131 Kahl S, Glasbrenner B, Zimmermann S. et al. Endoscopic ultrasound in pancreatic diseases. Dig Dis 2002; 20: 120-126
• 132 Sahai AV, Zimmerman M, Aabakken L. et al. Prospective assessment of the ability of endoscopic ultrasound to diagnose, exclude, or establish the severity of chronic pancreatitis found by endoscopic retrograde cholangiopancreatography. Gastrointest Endosc 1998; 48: 18-25
• 133 Gebel M, Stiehl M, Freise J. Value of sonographic imaging of the pancreatic duct for the diagnosis of chronic pancreatitis and pancreatic cancer compared to ERCP. Ultraschall Med 1985; 6: 127-130
• 134 Kahl S, Glasbrenner B, Leodolter A. et al. EUS in the diagnosis of early chronic pancreatitis: a prospective follow-up study. Gastrointest Endosc 2002; 55: 507-511
• 135 Sarner M, Cotton PB. Classification of pancreatitis. Gut 1984; 25: 756-759
• 136 Sai JK, Suyama M, Kubokawa Y. et al. Diagnosis of mild chronic pancreatitis (Cambridge classification): comparative study using secretin injection-magnetic resonance cholangiopancreatography and endoscopic retrograde pancreatography. World J Gastroenterol 2008; 14: 1218-1221
• 137 Catalano MF, Lahoti S, Geenen JE. et al. Prospective evaluation of endoscopic ultrasonography, endoscopic retrograde pancreatography, and secretin test in the diagnosis of chronic pancreatitis. Gastrointest Endosc 1998; 48: 11-17
• 138 Janssen J, Schlorer E, Greiner L. EUS elastography of the pancreas: feasibility and pattern description of the normal pancreas, chronic pancreatitis, and focal pancreatic lesions. Gastrointest Endosc 2007; 65: 971-978
• 139 Saftoiu A, Vilmann P, Gorunescu F. et al. Neural network analysis of dynamic sequences of EUS elastography used for the differential diagnosis of chronic pancreatitis and pancreatic cancer. Gastrointest Endosc 2008; 68: 1086-1094
• 140 Iglesias-Garcia J, Larino-Noia J, Abdulkader I. et al. Quantitative endoscopic ultrasound elastography: an accurate method for the differentiation of solid pancreatic masses. Gastroenterology 139: 1172-1180
• 141 Dietrich CF, Hirche TO, Ott M. et al. Real-time tissue elastography in the diagnosis of autoimmune pancreatitis. Endoscopy 2009; 41: 718-720
• 142 Bagul A, Siriwardena AK. Evaluation of the Manchester classification system for chronic pancreatitis. JOP 2006; 7: 390-396
• 143 Buchler MW, Martignoni ME, Friess H. et al. A proposal for a new clinical classification of chronic pancreatitis. BMC Gastroenterol 2009; 9: 93
• 144 Ramesh H. Proposal for a new grading system for chronic pancreatitis: the ABC system. J Clin Gastroenterol 2002; 35: 67-70
• 145 Schneider A, Lohr JM, Singer MV. The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease. J Gastroenterol 2007; 42: 101-119
• 146 Balthazar EJ, Robinson DL, Megibow AJ. et al. Acute pancreatitis: value of CT in establishing prognosis. Radiology 1990; 174: 331-336
• 147 Balthazar EJ, Freeny PC, vanSonnenberg E. Imaging and intervention in acute pancreatitis. Radiology 1994; 193: 297-306
• 148 Arvanitakis M, Delhaye M, De Maertelaere V. et al. Computed tomography and magnetic resonance imaging in the assessment of acute pancreatitis. Gastroenterology 2004; 126: 715-723
• 149 Rickes S, Uhle C, Kahl S. et al. Echo enhanced ultrasound: a new valid initial imaging approach for severe acute pancreatitis. Gut 2006; 55: 74-78
• 150 Brugge WR. Role of endoscopic ultrasound in the diagnosis of cystic lesions of the pancreas. Pancreatology 2001; 1: 637-640
• 151 Lerch MM, Stier A, Wahnschaffe U. et al. Pancreatic pseudocysts: observation, endoscopic drainage, or resection?. Dtsch Arztebl Int 2009; 106: 614-621
• 152 Will U, Mueller A, Topalidis T. et al. Value of endoscopic ultrasonography-guided fine needle aspiration (FNA) in the diagnosis of neoplastic tumor(-like) pancreatic lesions in daily clinical practice. Ultraschall Med 31: 169-174
• 153 Fritscher-Ravens A, Brand L, Knofel WT. et al. Comparison of endoscopic ultrasound-guided fine needle aspiration for focal pancreatic lesions in patients with normal parenchyma and chronic pancreatitis. Am J Gastroenterol 2002; 97: 2768-2775
• 154 Adler G, Seufferlein T. ZfG 2007: A successful interim result. Z Gastroenterol 2007; 45: 943
• 155 Kim JK, Altun E, Elias J. et al. Focal pancreatic mass: distinction of pancreatic cancer from chronic pancreatitis using gadolinium-enhanced 3D-gradient-echo MRI. J Magn Reson Imaging 2007; 26: 313-322
• 156 Hocke M, Schmidt C, Zimmer B. et al. Contrast enhanced endosonography for improving differential diagnosis between chronic pancreatitis and pancreatic cancer. Dtsch Med Wochenschr 2008; 133: 1888-1892
• 157 Krishna NB, Mehra M, Reddy AV. et al. EUS/EUS-FNA for suspected pancreatic cancer: influence of chronic pancreatitis and clinical presentation with or without obstructive jaundice on performance characteristics. Gastrointest Endosc 2009; 70: 70-79
• 158 Saftoiu A, Popescu C, Cazacu S. et al. Power Doppler endoscopic ultrasonography for the differential diagnosis between pancreatic cancer and pseudotumoral chronic pancreatitis. J Ultrasound Med 2006; 25: 363-372
• 159 Napoleon B, Alvarez-Sanchez MV, Gincoul R. et al. Contrast-enhanced harmonic endoscopic ultrasound in solid lesions of the pancreas: results of a pilot study. Endoscopy 42: 564-570
• 160 Ardengh JC, Paulo GA, Nakao FS. et al. Endoscopic ultrasound guided fine-needle aspiration core biopsy: comparison between an automatic biopsy device and two conventional needle systems. Acta Gastroenterol Latinoam 2008; 38: 105-115
• 161 Horwhat JD, Paulson EK, McGrath K. et al. A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions. Gastrointest Endosc 2006; 63: 966-975
• 162 Chari ST. Diagnosis of autoimmune pancreatitis using its five cardinal features: introducing the Mayo Clinic's HISORt criteria. J Gastroenterol 2007; 42 (Suppl. 18) 39-41
• 163 Choi EK, Kim MH, Kim JC. et al. The Japanese diagnostic criteria for autoimmune chronic pancreatitis: is it completely satisfactory?. Pancreas 2006; 33: 13-19
• 164 Lerch MM, Mayerle J. The benefits of diagnostic ERCP in autoimmune pancreatitis. Gut 60: 565-566
• 165 Sugumar A, Levy MJ, Kamisawa T. et al. Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis: an international multicentre study. Gut 60: 666-670
• 166 Hirota M, Takada T, Kawarada Y. et al. JPN Guidelines for the management of acute pancreatitis: severity assessment of acute pancreatitis. J Hepatobiliary Pancreat Surg 2006; 13: 33-41
• 167 Hirota M, Takada T, Kitamura N. et al. Fundamental and intensive care of acute pancreatitis. J Hepatobiliary Pancreat Sci 17: 45-52
• 168 Gardner TB, Vege SS, Chari ST. et al. Faster rate of initial fluid resuscitation in severe acute pancreatitis diminishes in-hospital mortality. Pancreatology 2009; 9: 770-776
• 169 Wu BU, Johannes RS, Conwell DL. et al. Early hemoconcentration predicts increased mortality only among transferred patients with acute pancreatitis. Pancreatology 2009; 9: 639-643
• 170 Wu BU, Johannes RS, Sun X. et al. Early changes in blood urea nitrogen predict mortality in acute pancreatitis. Gastroenterology 2009; 137: 129-135
• 171 Brunkhorst FM, Engel C, Bloos F. et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358: 125-139
• 172 Lankisch PG, Mahlke R, Blum T. et al. Hemoconcentration: an early marker of severe and/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol 2001; 96: 2081-2085
• 173 Banks PA, Freeman ML. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006; 101: 2379-2400
• 174 Field BE, Hepner GW, Shabot MM. et al. Nasogastric suction in alcoholic pancreatitis. Dig Dis Sci 1979; 24: 339-344
• 175 Fuller RK, Loveland JP, Frankel MH. An evaluation of the efficacy of nasogastric suction treatment in alcoholic pancreatitis. Am J Gastroenterol 1981; 75: 349-353
• 176 Naeije R, Salingret E, Clumeck N. et al. Is nasogastric suction necessary in acute pancreatitis?. Br Med J 1978; 2: 659-660
• 177 Sarr MG, Sanfey H, Cameron JL. Prospective, randomized trial of nasogastric suction in patients with acute pancreatitis. Surgery 1986; 100: 500-504
• 178 Jakobs R, Adamek MU, von Bubnoff AC. et al. Buprenorphine or procaine for pain relief in acute pancreatitis. A prospective randomized study. Scand J Gastroenterol 2000; 35: 1319-1323
• 179 Staritz M. Pharmacology of the sphincter of Oddi. Endoscopy 1988; 20 (Suppl. 01) 171-174
• 180 Niesel HC, Klimpel L, Kaiser H. et al. Epidural blockade for analgesia and treatment of acute pancreatitis. Reg Anaesth 1991; 14: 97-100
• 181 Bernhardt A, Kortgen A, Niesel H. et al. Using epidural anesthesia in patients with acute pancreatitis – prospective study of 121 patients. Anaesthesiol Reanim 2002; 27: 16-22
• 182 Thompson DR. Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis. Am J Gastroenterol 2001; 96: 1266-1272
• 183 Niederau C, Niederau M, Luthen R. et al. Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology 1990; 99: 1120-1127
• 184 Eatock FC, Brombacher GD, Steven A. et al. Nasogastric feeding in severe acute pancreatitis may be practical and safe. Int J Pancreatol 2000; 28: 23-29
• 185 McClave SA, Greene LM, Snider HL. et al. Comparison of the safety of early enteral vs parenteral nutrition in mild acute pancreatitis. JPEN J Parenter Enteral Nutr 1997; 21: 14-20
• 186 Olah A, Belagyi T, Issekutz A. et al. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg 2002; 89: 1103-1107
• 187 Powell JJ, Murchison JT, Fearon KC. et al. Randomized controlled trial of the effect of early enteral nutrition on markers of the inflammatory response in predicted severe acute pancreatitis. Br J Surg 2000; 87: 1375-1381
• 188 Pupelis G, Selga G, Austrums E. et al. Jejunal feeding, even when instituted late, improves outcomes in patients with severe pancreatitis and peritonitis. Nutrition 2001; 17: 91-94
• 189 Sax HC, Warner BW, Talamini MA. et al. Early total parenteral nutrition in acute pancreatitis: lack of beneficial effects. Am J Surg 1987; 153: 117-124
• 190 Windsor AC, Kanwar S, Li AG. et al. Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 1998; 42: 431-435
• 191 Karamitsios N, Saltzman JR. Enteral nutrition in acute pancreatitis. Nutr Rev 1997; 55: 279-282
• 192 Petrov MS, Kukosh MV, Emelyanov NV. A randomized controlled trial of enteral versus parenteral feeding in patients with predicted severe acute pancreatitis shows a significant reduction in mortality and in infected pancreatic complications with total enteral nutrition. Dig Surg 2006; 23: 336-344 ; discussion 344-335
• 193 Eckerwall GE, Axelsson JB, Andersson RG. Early nasogastric feeding in predicted severe acute pancreatitis: A clinical, randomized study. Ann Surg 2006; 244: 959-965 ; discussion 965-957
• 194 Eatock FC, Chong P, Menezes N. et al. A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 2005; 100: 432-439
• 195 Imrie CW, Carter CR, McKay CJ. Enteral and parenteral nutrition in acute pancreatitis. Best Pract Res Clin Gastroenterol 2002; 16: 391-397
• 196 Kumar A, Singh N, Prakash S. et al. Early enteral nutrition in severe acute pancreatitis: a prospective randomized controlled trial comparing nasojejunal and nasogastric routes. J Clin Gastroenterol 2006; 40: 431-434
• 197 Lecleire S, Antonietti M, Ben-Soussan E. et al. Nasojejunal feeding in patients with severe acute pancreatitis: comparison of endoscopic and self-migration tube placement. Pancreas 2007; 35: 376-378
• 198 Huber W, Umgelter A, Reindl W. et al. Volume assessment in patients with necrotizing pancreatitis: a comparison of intrathoracic blood volume index, central venous pressure, and hematocrit, and their correlation to cardiac index and extravascular lung water index. Crit Care Med 2008; 36: 2348-2354
• 199 Levy P, Heresbach D, Pariente EA. et al. Frequency and risk factors of recurrent pain during refeeding in patients with acute pancreatitis: a multivariate multicentre prospective study of 116 patients. Gut 1997; 40: 262-266
• 200 Petrov MS, van Santvoort HC, Besselink MG. et al. Oral refeeding after onset of acute pancreatitis: a review of literature. Am J Gastroenterol 2007; 102: 2079-2084
• 201 Eckerwall GE, Tingstedt BB, Bergenzaun PE. et al. Immediate oral feeding in patients with mild acute pancreatitis is safe and may accelerate recovery--a randomized clinical study. Clin Nutr 2007; 26: 758-763
• 202 Teich N, Aghdassi A, Fischer J. et al. Optimal timing of oral refeeding in mild acute pancreatitis: results of an open randomized multicenter trial. Pancreas 39: 1088-1092
• 203 Weimann A, Braunert M, Muller T. et al. Feasibility and safety of needle catheter jejunostomy for enteral nutrition in surgically treated severe acute pancreatitis. JPEN J Parenter Enteral Nutr 2004; 28: 324-327
• 204 Zhihui T, Wenkui Y, Weiqin L. et al. A randomised clinical trial of transnasal endoscopy versus fluoroscopy for the placement of nasojejunal feeding tubes in patients with severe acute pancreatitis. Postgrad Med J 2009; 85: 59-63
• 205 Sahin H, Mercanligil SM, Inanc N. et al. Effects of glutamine-enriched total parenteral nutrition on acute pancreatitis. Eur J Clin Nutr 2007; 61: 1429-1434
• 206 Fuentes-Orozco C, Cervantes-Guevara G, Mucino-Hernandez I. et al. L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. JPEN J Parenter Enteral Nutr 2008; 32: 403-411
• 207 Wang X, Li W, Zhang F. et al. Fish oil-supplemented parenteral nutrition in severe acute pancreatitis patients and effects on immune function and infectious risk: a randomized controlled trial. Inflammation 2009; 32: 304-309
• 208 Petrov MS, Loveday BP, Pylypchuk RD. et al. Systematic review and meta-analysis of enteral nutrition formulations in acute pancreatitis. Br J Surg 2009; 96: 1243-1252
• 209 Dellinger EP, Tellado JM, Soto NE. et al. Early antibiotic treatment for severe acute necrotizing pancreatitis: a randomized, double-blind, placebo-controlled study. Ann Surg 2007; 245: 674-683
• 210 Xu T, Cai Q. Prophylactic antibiotic treatment in acute necrotizing pancreatitis: results from a meta-analysis. Scand J Gastroenterol 2008; 43: 1249-1258
• 211 Villatoro E, Mulla M, Larvin M. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. Cochrane Database Syst Rev: CD002941
• 212 Hart PA, Bechtold ML, Marshall JB. et al. Prophylactic antibiotics in necrotizing pancreatitis: a meta-analysis. South Med J 2008; 101: 1126-1131
• 213 Xue P, Deng LH, Zhang ZD. et al. Effect of antibiotic prophylaxis on acute necrotizing pancreatitis: results of a randomized controlled trial. J Gastroenterol Hepatol 2009; 24: 736-742
• 214 Isenmann R, Runzi M, Kron M. et al. Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial. Gastroenterology 2004; 126: 997-1004
• 215 Rokke O, Harbitz TB, Liljedal J. et al. Early treatment of severe pancreatitis with imipenem: a prospective randomized clinical trial. Scand J Gastroenterol 2007; 42: 771-776
• 216 de Vries AC, Besselink MG, Buskens E. et al. Randomized controlled trials of antibiotic prophylaxis in severe acute pancreatitis: relationship between methodological quality and outcome. Pancreatology 2007; 7: 531-538
• 217 Olah A, Belagyi T, Issekutz A. et al. Combination of early nasojejunal feeding with modern synbiotic therapy in the treatment of severe acute pancreatitis (prospective, randomized, double-blind study). Magy Seb 2005; 58: 173-178
• 218 Besselink MG, van Santvoort HC, Buskens E. et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 371: 651-659
• 219 Sand J, Nordback I. Probiotics in severe acute pancreatitis. Lancet 2008; 371: 634-635
• 220 Zhang MM, Cheng JQ, Lu YR. et al. Use of pre-, pro- and synbiotics in patients with acute pancreatitis: a meta-analysis. World J Gastroenterol 16: 3970-3978
• 221 Besselink MG, van Santvoort HC, Boermeester MA. et al. Timing and impact of infections in acute pancreatitis. Br J Surg 2009; 96: 267-273
• 222 Sharma M, Banerjee D, Garg PK. Characterization of newer subgroups of fulminant and subfulminant pancreatitis associated with a high early mortality. Am J Gastroenterol 2007; 102: 2688-2695
• 223 Nieuwenhuijs VB, Besselink MG, van Minnen LP. et al. Surgical management of acute necrotizing pancreatitis: a 13-year experience and a systematic review. Scand J Gastroenterol Suppl 2003; 111-116
• 224 Connor S, Alexakis N, Raraty MG. et al. Early and late complications after pancreatic necrosectomy. Surgery 2005; 137: 499-505
• 225 Mier J, Leon EL, Castillo A. et al. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg 1997; 173: 71-75
• 226 Runzi M, Niebel W, Goebell H. et al. Severe acute pancreatitis: nonsurgical treatment of infected necroses. Pancreas 2005; 30: 195-199
• 227 Shankar S, vanSonnenberg E, Silverman SG. et al. Imaging and percutaneous management of acute complicated pancreatitis. Cardiovasc Intervent Radiol 2004; 27: 567-580
• 228 Werner J, Feuerbach S, Uhl W. et al. Management of acute pancreatitis: from surgery to interventional intensive care. Gut 2005; 54: 426-436
• 229 van Santvoort HC, Besselink MG, Bakker OJ. et al. A step-up approach or open necrosectomy for necrotizing pancreatitis. N Engl J Med 362: 1491-1502
• 230 Raczynski S, Teich N, Borte G. et al. Percutaneous transgastric irrigation drainage in combination with endoscopic necrosectomy in necrotizing pancreatitis (with videos). Gastrointest Endosc 2006; 64: 420-424
• 231 Seewald S, Groth S, Omar S. et al. Aggressive endoscopic therapy for pancreatic necrosis and pancreatic abscess: a new safe and effective treatment algorithm (videos). Gastrointest Endosc 2005; 62: 92-100
• 232 Seifert H, Wehrmann T, Schmitt T. et al. Retroperitoneal endoscopic debridement for infected peripancreatic necrosis. Lancet 2000; 356: 653-655
• 233 Hocke M, Will U, Gottschalk P, Settmacher U, Stallmach A. Transgastral retroperitoneal endoscopy in septic patients with pancreatic necrosis or infected pancreatic pseudocysts. Z Gastroenterol 2008; 46: 1363-1368
• 234 Niederau C, Hippenstiel J. Conservative management of acute pancreatitis: complications and outcome in a community-based hospital. Pancreas 2006; 32: 67-79
• 235 Ramesh H, Prakash K, Lekha V. et al. Are some cases of infected pancreatic necrosis treatable without intervention?. Dig Surg 2003; 20: 296-299 ; discussion 300
• 236 Besselink MG, van Santvoort HC, Nieuwenhuijs VB. et al. Minimally invasive “step-up approach” versus maximal necrosectomy in patients with acute necrotising pancreatitis (PANTER trial): design and rationale of a randomised controlled multicenter trial [ISRCTN38327949]. BMC Surg 2006; 6: 6
• 237 Besselink MG, van Santvoort HC, Schaapherder AF. et al. Feasibility of minimally invasive approaches in patients with infected necrotizing pancreatitis. Br J Surg 2007; 94: 604-608
• 238 Besselink MG, van Santvoort HC, Witteman BJ. et al. Management of severe acute pancreatitis: it's all about timing. Curr Opin Crit Care 2007; 13: 200-206
• 239 van Santvoort HC, Besselink MG, Bollen TL. et al. Case-matched comparison of the retroperitoneal approach with laparotomy for necrotizing pancreatitis. World J Surg 2007; 31: 1635-1642
• 240 van Santvoort HC, Besselink MG, Horvath KD. et al. Videoscopic assisted retroperitoneal debridement in infected necrotizing pancreatitis. HPB (Oxford) 2007; 9: 156-159
• 241 Seifert H, Biermer M, Schmitt W. et al. Transluminal endoscopic necrosectomy after acute pancreatitis: a multicentre study with long-term follow-up (the GEPARD Study). Gut 2009; 58: 1260-1266
• 242 Chauhan S, Forsmark CE. Pain management in chronic pancreatitis: A treatment algorithm. Best Pract Res Clin Gastroenterol 24: 323-335
• 243 Dite P, Ruzicka M, Zboril V. et al. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis. Endoscopy 2003; 35: 553-558
• 244 Cahen DL, Gouma DJ, Nio Y. et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N Engl J Med 2007; 356: 676-684
• 245 Neoptolemos JP, Stocken DD, Bassi C. et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 304: 1073-1081
• 246 Burris 3rd HA, Moore MJ. et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997; 15: 2403-2413
• 247 Izbicki JR, Yekebas EF, Strate T. et al. Extrahepatic portal hypertension in chronic pancreatitis: an old problem revisited. Ann Surg 2002; 236: 82-89
• 248 Beger HG, Schlosser W, Friess HM. et al. Duodenum-preserving head resection in chronic pancreatitis changes the natural course of the disease: a single-center 26-year experience. Ann Surg 1999; 230: 512-519 ; discussion 519-523
• 249 Vijungco JD, Prinz RA. Management of biliary and duodenal complications of chronic pancreatitis. World J Surg 2003; 27: 1258-1270
• 250 Cahen DL, van Berkel AM, Oskam D. et al. Long-term results of endoscopic drainage of common bile duct strictures in chronic pancreatitis. Eur J Gastroenterol Hepatol 2005; 17: 103-108
• 251 Kahl S, Zimmermann S, Genz I. et al. Risk factors for failure of endoscopic stenting of biliary strictures in chronic pancreatitis: a prospective follow-up study. Am J Gastroenterol 2003; 98: 2448-2453
• 252 Smith MT, Sherman S, Ikenberry SO, Hawes RH, Lehman GA. Alterations in pancreatic ductal morphology following polyethylene pancreatic stent therapy. Gastrointest Endosc 1996; 44: 268-275
• 253 Kozarek RA. Pancreatic stents can induce ductal changes consistent with chronic pancreatitis. Gastrointest Endosc 1990; 36: 93-95
• 254 Nguyen-Tang T, Dumonceau JM. Endoscopic treatment in chronic pancreatitis, timing, duration and type of intervention. Best Pract Res Clin Gastroenterol 24: 281-298
• 255 Barthet M, Bugallo M, Moreira LS. et al. Management of cysts and pseudocysts complicating chronic pancreatitis. A retrospective study of 143 patients. Gastroenterol Clin Biol 1993; 17: 270-276
• 256 Andren-Sandberg A, Dervenis C. Surgical treatment of pancreatic pseudocysts in the 2000's--laparoscopic approach. Acta Chir Iugosl 2003; 50: 21-26
• 257 Traverso LW, Tompkins RK, Urrea PT. et al. Surgical treatment of chronic pancreatitis. Twenty-two years' experience. Ann Surg 1979; 190: 312-319
• 258 Usatoff V, Brancatisano R, Williamson RC. Operative treatment of pseudocysts in patients with chronic pancreatitis. Br J Surg 2000; 87: 1494-1499
• 259 Nealon WH, Walser E. Duct drainage alone is sufficient in the operative management of pancreatic pseudocyst in patients with chronic pancreatitis. Ann Surg 2003; 237: 614-620 ; discussion 620-612
• 260 Cheruvu CV, Clarke MG, Prentice M. et al. Conservative treatment as an option in the management of pancreatic pseudocyst. Ann R Coll Surg Engl 2003; 85: 313-316
• 261 Bartoli E, Delcenserie R, Yzet T. et al. Endoscopic treatment of chronic pancreatitis. Gastroenterol Clin Biol 2005; 29: 515-521
• 262 Johnson MD, Walsh RM, Henderson JM. et al. Surgical versus nonsurgical management of pancreatic pseudocysts. J Clin Gastroenterol 2009; 43: 586-590
• 263 Aghdassi A, Mayerle J, Kraft M. et al. Diagnosis and treatment of pancreatic pseudocysts in chronic pancreatitis. Pancreas 2008; 36: 105-112
• 264 NIH state-of-the-science statement on endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and therapy. NIH Consens State Sci Statements 2002; 19: 1-26
• 265 Barthet M, Lamblin G, Gasmi M. et al. Clinical usefulness of a treatment algorithm for pancreatic pseudocysts. Gastrointest Endosc 2008; 67: 245-252
• 266 Gouyon B, Levy P, Ruszniewski P. et al. Predictive factors in the outcome of pseudocysts complicating alcoholic chronic pancreatitis. Gut 1997; 41: 821-825
• 267 Bradley EL, Clements Jr JL , Gonzalez AC. The natural history of pancreatic pseudocysts: a unified concept of management. Am J Surg 1979; 137: 135-141
• 268 Varadarajulu S, Christein JD, Tamhane A. et al. Prospective randomized trial comparing EUS and EGD for transmural drainage of pancreatic pseudocysts (with videos). Gastrointest Endosc 2008; 68: 1102-1111
• 269 Tanaka M, Chari S, Adsay V. et al. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006; 6: 17-32
• 270 Brugge WR, Lewandrowski K, Lee-Lewandrowski E. et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 2004; 126: 1330-1336
• 271 Spinelli KS, Fromwiller TE, Daniel RA. et al. Cystic pancreatic neoplasms: observe or operate. Ann Surg 2004; 239: 651-657 ; discussion 657-659
• 272 Grutzmann R, Niedergethmann M, Pilarsky C. et al. Intraductal papillary mucinous tumors of the pancreas: biology, diagnosis, and treatment. Oncologist 15: 1294-1309
• 273 Megibow AJ, Baker ME, Gore RM. et al. The incidental pancreatic cyst. Radiol Clin North Am 49: 349-359
• 274 Werner J, Bartosch HRA, Andersson R. Cystic pancreatic lesions: Current evidence for diagnosis and treatment. Scand J Gastroenterol 2011; 46: 773-788
• 275 Barthet M, Sahel J, Bodiou-Bertei C. et al. Endoscopic transpapillary drainage of pancreatic pseudocysts. Gastrointest Endosc 1995; 42: 208-213
• 276 Udd M, Leppaniemi AK, Bidel S. et al. Treatment of bleeding pseudoaneurysms in patients with chronic pancreatitis. World J Surg 2007; 31: 504-510
• 277 Widdison AL, Alvarez C, Karanjia ND. et al. Experimental evidence of beneficial effects of ductal decompression in chronic pancreatitis. Endoscopy 1991; 23: 151-154
• 278 Treacy PJ, Worthley CS. Pancreatic stents in the management of chronic pancreatitis. Aust N Z J Surg 1996; 66: 210-213
• 279 Rosch T, Daniel S, Scholz M. et al. Endoscopic treatment of chronic pancreatitis: a multicenter study of 1000 patients with long-term follow-up. Endoscopy 2002; 34: 765-771
• 280 Cremer M, Deviere J, Delhaye M. et al. Stenting in severe chronic pancreatitis: results of medium-term follow-up in seventy-six patients. Endoscopy 1991; 23: 171-176
• 281 McCarthy J, Geenen JE, Hogan WJ. Preliminary experience with endoscopic stent placement in benign pancreatic diseases. Gastrointest Endosc 1988; 34: 16-18
• 282 Binmoeller KF, Jue P, Seifert H. et al. Endoscopic pancreatic stent drainage in chronic pancreatitis and a dominant stricture: long-term results. Endoscopy 1995; 27: 638-644
• 283 Huibregtse K, Schneider B, Vrij AA. et al. Endoscopic pancreatic drainage in chronic pancreatitis. Gastrointest Endosc 1988; 34: 9-15
• 284 Kozarek RA. Endoscopic treatment of chronic pancreatitis. Indian J Gastroenterol 2002; 21: 67-73
• 285 Kozarek RA, Ball TJ, Patterson DJ. et al. Endoscopic transpapillary therapy for disrupted pancreatic duct and peripancreatic fluid collections. Gastroenterology 1991; 100: 1362-1370
• 286 Kozarek RA, Patterson DJ, Ball TJ. et al. Endoscopic placement of pancreatic stents and drains in the management of pancreatitis. Ann Surg 1989; 209: 261-266
• 287 Kozarek RA, Traverso LW. Endotherapy for chronic pancreatitis. Int J Pancreatol 1996; 19: 93-102
• 288 Ponchon T, Bory RM, Hedelius F. et al. Endoscopic stenting for pain relief in chronic pancreatitis: results of a standardized protocol. Gastrointest Endosc 1995; 42: 452-456
• 289 Smits ME, Rauws EA, van Gulik TM. et al. Long-term results of endoscopic stenting and surgical drainage for biliary stricture due to chronic pancreatitis. Br J Surg 1996; 83: 764-768
• 290 Boerma D, van Gulik TM, Rauws EA. et al. Outcome of pancreaticojejunostomy after previous endoscopic stenting in patients with chronic pancreatitis. Eur J Surg 2002; 168: 223-228
• 291 Sauer B, Talreja J, Ellen K. et al. Temporary placement of a fully covered self-expandable metal stent in the pancreatic duct for management of symptomatic refractory chronic pancreatitis: preliminary data (with videos). Gastrointest Endosc 2008; 68: 1173-1178
• 292 Kahl S, Zimmermann S, Glasbrenner B. et al. Treatment of benign biliary strictures in chronic pancreatitis by self-expandable metal stents. Dig Dis 2002; 20: 199-203
• 293 Guda NM, Partington S, Freeman ML. Extracorporeal shock wave lithotripsy in the management of chronic calcific pancreatitis: a meta-analysis. JOP 2005; 6: 6-12
• 294 Schneider HT, May A, Benninger J. et al. Piezoelectric shock wave lithotripsy of pancreatic duct stones. Am J Gastroenterol 1994; 89: 2042-2048
• 295 Dumonceau JM, Costamagna G, Tringali A. et al. Treatment for painful calcified chronic pancreatitis: extracorporeal shock wave lithotripsy versus endoscopic treatment: a randomised controlled trial. Gut 2007; 56: 545-552
• 296 Adamek HE, Jakobs R, Buttmann A. et al. Long term follow up of patients with chronic pancreatitis and pancreatic stones treated with extracorporeal shock wave lithotripsy. Gut 1999; 45: 402-405
• 297 Brand B, Kahl M, Sidhu S. et al. Prospective evaluation of morphology, function, and quality of life after extracorporeal shockwave lithotripsy and endoscopic treatment of chronic calcific pancreatitis. Am J Gastroenterol 2000; 95: 3428-3438
• 298 Barrioz T, Ingrand P, Besson I. et al. Randomised trial of prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin. Lancet 1994; 344: 581-582
• 299 Ghosh S, Palmer KR. Prevention of biliary stent occlusion using cyclical antibiotics and ursodeoxycholic acid. Gut 1994; 35: 1757-1759
• 300 Ghosh S, Palmer KR. Preventing biliary stent occlusion. Lancet 1994; 344: 1087-1088 ; author reply 1088-1089
• 301 Groen AK, Out T, Huibregtse K. et al. Characterization of the content of occluded biliary endoprostheses. Endoscopy 1987; 19: 57-59
• 302 Smit JM, Out MM, Groen AK. et al. A placebo-controlled study on the efficacy of aspirin and doxycycline in preventing clogging of biliary endoprostheses. Gastrointest Endosc 1989; 35: 485-489
• 303 Mayerle J, Stier A, Lerch MM. et al. [Chronic pancreatitis. Diagnosis and treatment]. Chirurg 2004; 75: 731-747 ; quiz 748
• 304 Catalano MF, Linder JD, George S. et al. Treatment of symptomatic distal common bile duct stenosis secondary to chronic pancreatitis: comparison of single vs. multiple simultaneous stents. Gastrointest Endosc 2004; 60: 945-952
• 305 van Boeckel PG, Vleggaar FP, Siersema PD. Plastic or metal stents for benign extrahepatic biliary strictures: a systematic review. BMC Gastroenterol 2009; 9: 96
• 306 Behm B, Brock A, Clarke BW. et al. Partially covered self-expandable metallic stents for benign biliary strictures due to chronic pancreatitis. Endoscopy 2009; 41: 547-551
• 307 Wilcox CM, Varadarajulu S. Endoscopic therapy for chronic pancreatitis: an evidence-based review. Curr Gastroenterol Rep 2006; 8: 104-110
• 308 Smits ME, Rauws EA, Tytgat GN. et al. Endoscopic treatment of pancreatic stones in patients with chronic pancreatitis. Gastrointest Endosc 1996; 43: 556-560
• 309 Cahen D, Rauws E, Fockens P. et al. Endoscopic drainage of pancreatic pseudocysts: long-term outcome and procedural factors associated with safe and successful treatment. Endoscopy 2005; 37: 977-983
• 310 Farnbacher MJ, Rabenstein T, Ell C. et al. Is endoscopic drainage of common bile duct stenoses in chronic pancreatitis up-to-date?. Am J Gastroenterol 2000; 95: 1466-1471
• 311 Lawrence C, Romagnuolo J, Payne KM. et al. Low symptomatic premature stent occlusion of multiple plastic stents for benign biliary strictures: comparing standard and prolonged stent change intervals. Gastrointest Endosc 72: 558-563
• 312 McClaine RJ, Lowy AM, Matthews JB. et al. A comparison of pancreaticoduodenectomy and duodenum-preserving head resection for the treatment of chronic pancreatitis. HPB (Oxford) 2009; 11: 677-683
• 313 Muller MW, Friess H, Martin DJ. et al. Long-term follow-up of a randomized clinical trial comparing Beger with pylorus-preserving Whipple procedure for chronic pancreatitis. Br J Surg 2008; 95: 350-356
• 314 Riediger H, Adam U, Fischer E. et al. Long-term outcome after resection for chronic pancreatitis in 224 patients. J Gastrointest Surg 2007; 11: 949-959 ; discussion 959-960
• 315 van der Gaag NA, Rauws EA, van Eijck CH. et al. Preoperative biliary drainage for cancer of the head of the pancreas. N Engl J Med 2010; 362: 129-137
• 316 Mullady DK, Yadav D, Amann ST. et al. Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis: a prospective cohort study. Gut 60: 77-84
• 317 Bloechle C, Izbicki JR, Knoefel WT. et al. Quality of life in chronic pancreatitis--results after duodenum-preserving resection of the head of the pancreas. Pancreas 1995; 11: 77-85
• 318 Pezzilli R, Fantini L, Calculli L. et al. The quality of life in chronic pancreatitis: the clinical point of view. JOP 2006; 7: 113-116
• 319 Delcore R, Rodriguez FJ, Thomas JH. et al. The role of pancreatojejunostomy in patients without dilated pancreatic ducts. Am J Surg 1994; 168: 598-601 ; discussion 601-592
• 320 Malfertheiner P, Mayer D, Buchler M. et al. Treatment of pain in chronic pancreatitis by inhibition of pancreatic secretion with octreotide. Gut 1995; 36: 450-454
• 321 Lieb 2nd JG, Shuster JJ. et al. A pilot study of Octreotide LAR vs. octreotide tid for pain and quality of life in chronic pancreatitis. JOP 2009; 10: 518-522
• 322 Shafiq N, Rana S, Bhasin D. et al. Pancreatic enzymes for chronic pancreatitis. Cochrane Database Syst Rev 2009 CD0063022nd
• 323 Whitcomb DC, Lehman GA, Vasileva G. et al. Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial. Am J Gastroenterol 2010; 105: 2276-2286
• 324 Uden S, Bilton D, Nathan L. et al. Antioxidant therapy for recurrent pancreatitis: placebo-controlled trial. Aliment Pharmacol Ther 1990; 4: 357-371
• 325 Kirk GR, White JS, McKie L. et al. Combined antioxidant therapy reduces pain and improves quality of life in chronic pancreatitis. J Gastrointest Surg 2006; 10: 499-503
• 326 Bhardwaj P, Garg PK, Maulik SK. et al. A randomized controlled trial of antiioxidant supplementation for pain relief in patients with chronic pancreatitis. Gastroenterology 2009; 136: 149-159 e142
• 327 Omenn GS, Goodman GE, Thornquist MD. et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334: 1150-1155
• 328 The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med 1994; 330: 1029-1035
• 329 Ballegaard S, Christophersen SJ, Dawids SG. et al. Acupuncture and transcutaneous electric nerve stimulation in the treatment of pain associated with chronic pancreatitis. A randomized study. Scand J Gastroenterol 1985; 20: 1249-1254
• 330 Cartmell MT, O'Reilly DA, Porter C. et al. A double-blind placebo-controlled trial of a leukotriene receptor antagonist in chronic pancreatitis in humans. J Hepatobiliary Pancreat Surg 2004; 11: 255-259
• 331 Guarner L, Navalpotro B, Molero X. et al. Management of painful chronic pancreatitis with single-dose radiotherapy. Am J Gastroenterol 2009; 104: 349-355
• 332 Kaufman M, Singh G, Das S. et al. Efficacy of endoscopic ultrasound-guided celiac plexus block and celiac plexus neurolysis for managing abdominal pain associated with chronic pancreatitis and pancreatic cancer. J Clin Gastroenterol 2010; 44: 127-134
• 333 Puli SR, Reddy JB, Bechtold ML. et al. EUS-guided celiac plexus neurolysis for pain due to chronic pancreatitis or pancreatic cancer pain: a meta-analysis and systematic review. Dig Dis Sci 2009; 54: 2330-2337
• 334 Howard TJ, Swofford JB, Wagner DL. et al. Quality of life after bilateral thoracoscopic splanchnicectomy: long-term evaluation in patients with chronic pancreatitis. J Gastrointest Surg 2002; 6: 845-852 ; discussion 853-844
• 335 Stefaniak T, Vingerhoets A, Makarewicz W. et al. Opioid use determines success of videothoracoscopic splanchnicectomy in chronic pancreatic pain patients. Langenbecks Arch Surg 2008; 393: 213-218
• 336 Gress F, Schmitt C, Sherman S. et al. A prospective randomized comparison of endoscopic ultrasound- and computed tomography-guided celiac plexus block for managing chronic pancreatitis pain. Am J Gastroenterol 1999; 94: 900-905
• 337 LeBlanc JK, DeWitt J, Johnson C. et al. A prospective randomized trial of 1 versus 2 injections during EUS-guided celiac plexus block for chronic pancreatitis pain. Gastrointest Endosc 2009; 69: 835-842
• 338 Madsen P, Hansen E. Coeliac plexus block versus pancreaticogastrostomy for pain in chronic pancreatitis. A controlled randomized trial. Scand J Gastroenterol 1985; 20: 1217-1220
• 339 Santosh D, Lakhtakia S, Gupta R. et al. Clinical trial: a randomized trial comparing fluoroscopy guided percutaneous technique vs. endoscopic ultrasound guided technique of coeliac plexus block for treatment of pain in chronic pancreatitis. Aliment Pharmacol Ther 2009; 29: 979-984
• 340 Sahai AV, Lemelin V, Lam E. et al. Central vs. bilateral endoscopic ultrasound-guided celiac plexus block or neurolysis: a comparative study of short-term effectiveness. Am J Gastroenterol 2009; 104: 326-329
• 341 Deviere J, Bell Jr RH , Beger HG. et al. Treatment of chronic pancreatitis with endotherapy or surgery: critical review of randomized control trials. J Gastrointest Surg 2008; 12: 640-644
• 342 Regan PT, Malagelada JR, DiMagno EP. et al. Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. N Engl J Med 1977; 297: 854-858
• 343 Layer P, von der Ohe MR, Holst JJ. et al. Altered postprandial motility in chronic pancreatitis: role of malabsorption. Gastroenterology 1997; 112: 1624-1634
• 344 Wooldridge JL, Heubi JE, Amaro-Galvez R. et al. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros 2009; 8: 405-417
• 345 Layer P, Yamamoto H, Kalthoff L. et al. The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology 1994; 107: 1481-1487
• 346 Czako L, Takacs T, Hegyi P. et al. Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis. Can J Gastroenterol 2003; 17: 597-603
• 347 Dominguez-Munoz JE, Iglesias-Garcia J, Vilarino-Insua M. et al. 13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis. Clin Gastroenterol Hepatol 2007; 5: 484-488
• 348 Dominguez-Munoz JE, Iglesias-Garcia J. Oral pancreatic enzyme substitution therapy in chronic pancreatitis: is clinical response an appropriate marker for evaluation of therapeutic efficacy?. JOP 2010; 11: 158-162
• 349 Ritz MA, Fraser RJ, Di Matteo AC. et al. Evaluation of the 13C-triolein breath test for fat malabsorption in adult patients with cystic fibrosis. J Gastroenterol Hepatol 2004; 19: 448-453
• 350 Dominguez-Munoz JE, Iglesias-Garcia J, Iglesias-Rey M. et al. Effect of the administration schedule on the therapeutic efficacy of oral pancreatic enzyme supplements in patients with exocrine pancreatic insufficiency: a randomized, three-way crossover study. Aliment Pharmacol Ther 2005; 21: 993-1000
• 351 Heizer WD, Cleaveland CR, Iber FL. Gastric Inactivation of Pancreatic Supplements. Bull Johns Hopkins Hosp 1965; 116: 261-270
• 352 Delchier JC, Vidon N, Saint-Marc Girardin MF. et al. Fate of orally ingested enzymes in pancreatic insufficiency: comparison of two pancreatic enzyme preparations. Aliment Pharmacol Ther 1991; 5: 365-378
• 353 Meyer JH, Elashoff J, Porter-Fink V. et al. Human postprandial gastric emptying of 1-3-millimeter spheres. Gastroenterology 1988; 94: 1315-1325
• 354 Borowitz D, Goss CH, Limauro S. et al. Study of a novel pancreatic enzyme replacement therapy in pancreatic insufficient subjects with cystic fibrosis. J Pediatr 2006; 149: 658-662
• 355 Bruno MJ, Rauws EA, Hoek FJ. et al. Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy. Dig Dis Sci 1994; 39: 988-992
• 356 Bruno MJ, Borm JJ, Hoek FJ. et al. Comparative effects of enteric-coated pancreatin microsphere therapy after conventional and pylorus-preserving pancreatoduodenectomy. Br J Surg 1997; 84: 952-956
• 357 Durie PR, Bell L, Linton W. et al. Effect of cimetidine and sodium bicarbonate on pancreatic replacement therapy in cystic fibrosis. Gut 1980; 21: 778-786
• 358 Lankisch PG, Lembcke B, Kirchhoff S. et al. Therapy of pancreatogenic steatorrhea. Comparison of 2 acid-protected enzyme preparations. Dtsch Med Wochenschr 1988; 113: 15-17
• 359 Carroccio A, Pardo F, Montalto G. et al. Use of famotidine in severe exocrine pancreatic insufficiency with persistent maldigestion on enzymatic replacement therapy. A long-term study in cystic fibrosis. Dig Dis Sci 1992; 37: 1441-1446
• 360 Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut 2005; 54 (Suppl. 06) vi1-28
• 361 Casellas F, Guarner L, Vaquero E. et al. Hydrogen breath test with glucose in exocrine pancreatic insufficiency. Pancreas 1998; 16: 481-486
• 362 Smyth RL, Ashby D, O'Hea U. et al. Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Lancet 1995; 346: 1247-1251
• 363 Serban DE, Florescu P, Miu N. Fibrosing colonopathy revealing cystic fibrosis in a neonate before any pancreatic enzyme supplementation. J Pediatr Gastroenterol Nutr 2002; 35: 356-359
• 364 Taylor CJ. Fibrosing colonopathy unrelated to pancreatic enzyme supplementation. J Pediatr Gastroenterol Nutr 2002; 35: 268-269
• 365 Waters BL. Cystic fibrosis with fibrosing colonopathy in the absence of pancreatic enzymes. Pediatr Dev Pathol 1998; 1: 74-78
• 366 Connett GJ, Lucas JS, Atchley JT. et al. Colonic wall thickening is related to age and not dose of high strength pancreatin microspheres in children with cystic fibrosis. Eur J Gastroenterol Hepatol 1999; 11: 181-183
• 367 O'Keefe SJ, Stevens S, Lee R. et al. Physiological evaluation of the severity of pancreatic exocrine dysfunction during endoscopy. Pancreas 2007; 35: 30-36
• 368 Nojgaard C. Prognosis of acute and chronic pancreatitis – a 30-year follow-up of a Danish cohort. Dan Med Bull 2010; 57: B4228
• 369 Hebuterne X, Hastier P, Peroux JL. et al. Resting energy expenditure in patients with alcoholic chronic pancreatitis. Dig Dis Sci 1996; 41: 533-539
• 370 Suzuki A, Mizumoto A, Sarr MG. et al. Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea?. Gastroenterology 1997; 112: 2048-2055
• 371 Caliari S, Benini L, Sembenini C. et al. Medium-chain triglyceride absorption in patients with pancreatic insufficiency. Scand J Gastroenterol 1996; 31: 90-94
• 372 Gullo L, Barbara L, Labo G. Effect of cessation of alcohol use on the course of pancreatic dysfunction in alcoholic pancreatitis. Gastroenterology 1988; 95: 1063-1068
• 373 Marotta F, Labadarios D, Frazer L. et al. Fat-soluble vitamin concentration in chronic alcohol-induced pancreatitis. Relationship with steatorrhea. Dig Dis Sci 1994; 39: 993-998
• 374 American Gastroenterological Association Medical Position Statement: treatment of pain in chronic pancreatitis. Gastroenterology 1998; 115: 763-764
• 375 Birkmeyer JD, Siewers AE, Finlayson EV. et al. Hospital volume and surgical mortality in the United States. N Engl J Med 2002; 346: 1128-1137
• 376 Fong Y, Gonen M, Rubin D. et al. Long-term survival is superior after resection for cancer in high-volume centers. Ann Surg 2005; 242: 540-544 ; discussion 544-547
• 377 Belina F, Fronek J, Ryska M. Duodenopancreatectomy versus duodenum-preserving pancreatic head excision for chronic pancreatitis. Pancreatology 2005; 5: 547-552
• 378 Witzigmann H, Max D, Uhlmann D. et al. Quality of life in chronic pancreatitis: a prospective trial comparing classical whipple procedure and duodenum-preserving pancreatic head resection. J Gastrointest Surg 2002; 6: 173-179 ; discussion 179-180
• 379 Hartwig W, Hackert T, Hinz U. et al. Pancreatic cancer surgery in the new millennium: better prediction of outcome. Ann Surg 2011; 254: 311-319
• 380 Strobel O, Buchler MW, Werner J. Duodenum-preserving pancreatic head resection: technique according to Beger, technique according to Frey and Berne modifications. Chirurg 2009; 80: 22-27
• 381 Witzigmann H, Max D, Uhlmann D. et al. Outcome after duodenum-preserving pancreatic head resection is improved compared with classic Whipple procedure in the treatment of chronic pancreatitis. Surgery 2003; 134: 53-62
• 382 Mobius C, Max D, Uhlmann D. et al. Five-year follow-up of a prospective non-randomised study comparing duodenum-preserving pancreatic head resection with classic Whipple procedure in the treatment of chronic pancreatitis. Langenbecks Arch Surg 2007; 392: 359-364
• 383 Izbicki JR, Bloechle C, Knoefel WT. et al. Drainage versus resection in surgical therapy of chronic pancreatitis of the head of the pancreas: a randomized study. Chirurg 1997; 68: 369-377
• 384 Diener MK, Bruckner T, Contin P. et al. ChroPac-trial: duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for chronic pancreatitis. Trial protocol of a randomised controlled multicentre trial. Trials 11: 47
• 385 Diener MK, Knaebel HP, Witte ST. et al. DISPACT trial: a randomized controlled trial to compare two different surgical techniques of DIStal PAnCreaTectomy – study rationale and design. Clin Trials 2008; 5: 534-545
• 386 Diener MK, Rahbari NN, Fischer L. et al. Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for surgical treatment of chronic pancreatitis: a systematic review and meta-analysis. Ann Surg 2008; 247: 950-961
• 387 Izbicki JR, Bloechle C, Broering DC. et al. Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg 1998; 228: 771-779
• 388 Izbicki JR, Bloechle C, Broering DC. et al. Longitudinal V-shaped excision of the ventral pancreas for small duct disease in severe chronic pancreatitis: prospective evaluation of a new surgical procedure. Ann Surg 1998; 227: 213-219
• 389 Koninger J, Seiler CM, Sauerland S. et al. Duodenum-preserving pancreatic head resection--a randomized controlled trial comparing the original Beger procedure with the Berne modification (ISRCTN No. 50638764). Surgery 2008; 143: 490-498
• 390 Muller MW, Friess H, Leitzbach S. et al. Perioperative and follow-up results after central pancreatic head resection (Berne technique) in a consecutive series of patients with chronic pancreatitis. Am J Surg 2008; 196: 364-372
• 391 Strate T, Bachmann K, Busch P. et al. Resection vs drainage in treatment of chronic pancreatitis: long-term results of a randomized trial. Gastroenterology 2008; 134: 1406-1411
• 392 Gloor B, Friess H, Uhl W. et al. A modified technique of the Beger and Frey procedure in patients with chronic pancreatitis. Dig Surg 2001; 18: 21-25
• 393 Buchler MW, Friess H, Muller MW. et al. Randomized trial of duodenum-preserving pancreatic head resection versus pylorus-preserving Whipple in chronic pancreatitis. Am J Surg 1995; 169: 65-69 ; discussion 69-70
• 394 Strate T, Taherpour Z, Bloechle C. et al. Long-term follow-up of a randomized trial comparing the beger and frey procedures for patients suffering from chronic pancreatitis. Ann Surg 2005; 241: 591-598
• 395 Duval Jr MK . Caudal pancreaticojejunostomy for chronic pancreatitis; operative criteria and technique. Surg Clin North Am 1956; 831-839
• 396 Partington PF. Chronic pancreatitis treated by Roux type jejunal anastomosis to the biliary tract. AMA Arch Surg 1952; 65: 532-542
• 397 Jimenez RE, Fernandez-Del Castillo C, Rattner DW. et al. Pylorus-preserving pancreaticoduodenectomy in the treatment of chronic pancreatitis. World J Surg 2003; 27: 1211-1216
• 398 Buchler MW, Warshaw AL. Resection versus drainage in treatment of chronic pancreatitis. Gastroenterology 2008; 134: 1605-1607
• 399 Beger HG, Witte C, Krautzberger W. et al. Experiences with duodenum-sparing pancreas head resection in chronic pancreatitis. Chirurg 1980; 51: 303-307
• 400 Bloechle C, Busch C, Tesch C. et al. Prospective randomized study of drainage and resection on non-occlusive segmental portal hypertension in chronic pancreatitis. Br J Surg 1997; 84: 477-482
• 401 Frey CF, Amikura K. Local resection of the head of the pancreas combined with longitudinal pancreaticojejunostomy in the management of patients with chronic pancreatitis. Ann Surg 1994; 220: 492-504 ; discussion 504-497
• 402 Frey CF, Smith GJ. Description and rationale of a new operation for chronic pancreatitis. Pancreas 1987; 2: 701-707
• 403 Yekebas EF, Bogoevski D, Honarpisheh H. et al. Long-term follow-up in small duct chronic pancreatitis: A plea for extended drainage by "V-shaped excision" of the anterior aspect of the pancreas. Ann Surg 2006; 244: 940-946 ; discussion 946-948
• 404 Bockhorn M, Gebauer F, Bogoevski D. et al. Chronic pancreatitis complicated by cavernous transformation of the portal vein: contraindication to surgery?. Surgery 2011; 149: 321-328
• 405 Shrikhande SV, Kleeff J, Friess H. et al. Management of pain in small duct chronic pancreatitis. J Gastrointest Surg 2006; 10: 227-233
• 406 Whipple AO, Parsons WB, Mullins CR. Treatment of Carcinoma of the Ampulla of Vater. Ann Surg 1935; 102: 763-779
• 407 Yeo CJ, Cameron JL, Sohn TA. et al. Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. Ann Surg 1999; 229: 613-622; discussion 622-614
• 408 Warshaw AL, Thayer SP. Pancreaticoduodenectomy. J Gastrointest Surg 2004; 8: 733-741
• 409 Cameron JL, Riall TS, Coleman J. et al. One thousand consecutive pancreaticoduodenectomies. Ann Surg 2006; 244: 10-15
• 410 Beger HG, Kunz R, Poch B. The Beger procedure--duodenum-preserving pancreatic head resection. J Gastrointest Surg 2004; 8: 1090-1097
• 411 Izbicki JR, Bloechle C, Knoefel WT. et al. Duodenum-preserving resection of the head of the pancreas in chronic pancreatitis. A prospective, randomized trial. Ann Surg 1995; 221: 350-358
• 412 Cataldegirmen G, Schneider CG, Bogoevski D. et al. Extended central pancreatic resection as an alternative for extended left or extended right resection for appropriate pancreatic neoplasms. Surgery 2010; 147: 331-338
• 413 Asanuma Y, Koyama K, Saito K. et al. An appraisal of segmental pancreatectomy for benign tumors of the pancreatic body: a report of two cases. Surg Today 1993; 23: 733-736
• 414 Christein JD, Kim AW, Golshan MA. et al. Central pancreatectomy for the resection of benign or low malignant potential neoplasms. World J Surg 2003; 27: 595-598
• 415 Iacono C, Bortolasi L, Serio G. Is there a place for central pancreatectomy in pancreatic surgery?. J Gastrointest Surg 1998; 2: 509-516 ; discussion 516-507
• 416 Ikeda S, Matsumoto S, Maeshiro K. et al. Segmental pancreatectomy for the diagnosis and treatment of small lesions in the neck or body of the pancreas. Hepatogastroenterology 1995; 42: 730-733
• 417 Rotman N, Sastre B, Fagniez PL. Medial pancreatectomy for tumors of the neck of the pancreas. Surgery 1993; 113: 532-535
• 418 Sperti C, Pasquali C, Ferronato A. et al. Median pancreatectomy for tumors of the neck and body of the pancreas. J Am Coll Surg 2000; 190: 711-716
• 419 Warshaw AL, Rattner DW, Fernandez-del CastilloC. et al. Middle segment pancreatectomy: a novel technique for conserving pancreatic tissue. Arch Surg 1998; 133: 327-331
• 420 Muller MW, Friess H, Kleeff J. et al. Middle segmental pancreatic resection: An option to treat benign pancreatic body lesions. Ann Surg 2006; 244: 909-918 ; discussion 918-920
• 421 Sauvanet A, Partensky C, Sastre B. et al. Medial pancreatectomy: a multi-institutional retrospective study of 53 patients by the French Pancreas Club. Surgery 2002; 132: 836-843
• 422 Partelli S, Boninsegna L, Salvia R. et al. Middle-preserving pancreatectomy for multicentric body-sparing lesions of the pancreas. Am J Surg 2009; 198: e49-53
• 423 Braasch JW, Vito L, Nugent FW. Total pancreatectomy of end-stage chronic pancreatitis. Ann Surg 1978; 188: 317-322
• 424 Rossi RL, Rothschild J, Braasch JW. et al. Pancreatoduodenectomy in the management of chronic pancreatitis. Arch Surg 1987; 122: 416-420
• 425 Balcom JHt, Rattner DW, Warshaw AL. et al. Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch Surg 2001; 136: 391-398
• 426 Buchler MW, Wagner M, Schmied BM. et al. Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy. Arch Surg 2003; 138: 1310-1314 ; discussion 1315
• 427 Pratt WB, Maithel SK, Vanounou T. et al. Clinical and economic validation of the International Study Group of Pancreatic Fistula (ISGPF) classification scheme. Ann Surg 2007; 245: 443-451
• 428 Reid-Lombardo KM, Farnell MB, Crippa S. et al. Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1 507 patients: a report from the Pancreatic Anastomotic Leak Study Group. J Gastrointest Surg 2007; 11: 1451-1458 ; discussion 1459
• 429 Reid-Lombardo KM, Ramos-De la Medina A, Thomsen K. et al. Long-term anastomotic complications after pancreaticoduodenectomy for benign diseases. J Gastrointest Surg 2007; 11: 1704-1711
• 430 Bassi C, Dervenis C, Butturini G. et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005; 138: 8-13
• 431 Welsch T, Borm M, Degrate L. et al. Evaluation of the International Study Group of Pancreatic Surgery definition of delayed gastric emptying after pancreatoduodenectomy in a high-volume centre. Br J Surg 2010; 97: 1043-1050
• 432 Welsch T, Frommhold K, Hinz U. et al. Persisting elevation of C-reactive protein after pancreatic resections can indicate developing inflammatory complications. Surgery 2008; 143: 20-28
• 433 Molinari E, Bassi C, Salvia R. et al. Amylase value in drains after pancreatic resection as predictive factor of postoperative pancreatic fistula: results of a prospective study in 137 patients. Ann Surg 2007; 246: 281-287
• 434 Seelig MH, Chromik AM, Weyhe D. et al. Pancreatic redo procedures: to do or not to do -- this is the question. J Gastrointest Surg 2007; 11: 1175-1182
• 435 Cruciani RA, Jain S. Pancreatic pain: a mini review. Pancreatology 2008; 8: 230-235
• 436 Laubenthal H, Becker M, Neugebauer E. Guideline: "Treatment of acute perioperative and posttraumatic pain". Updating from the S2- to the S3-level: a preliminary report. Anasthesiol Intensivmed Notfallmed Schmerzther 2006; 41: 470-472
• 437 Gueroult S, Parc Y, Duron F. et al. Completion pancreatectomy for postoperative peritonitis after pancreaticoduodenectomy: early and late outcome. Arch Surg 2004; 139: 16-19
• 438 de Castro SM, Busch OR, van Gulik TM. et al. Incidence and management of pancreatic leakage after pancreatoduodenectomy. Br J Surg 2005; 92: 1117-1123
• 439 Lowenfels AB, Maisonneuve P, Cavallini G. et al. Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group. Am J Gastroenterol 1994; 89: 1467-1471
• 440 Lowenfels AB, Sullivan T, Fiorianti J. et al. The epidemiology and impact of pancreatic diseases in the United States. Curr Gastroenterol Rep 2005; 7: 90-95
• 441 Levy P, Milan C, Pignon JP. et al. Mortality factors associated with chronic pancreatitis. Unidimensional and multidimensional analysis of a medical-surgical series of 240 patients. Gastroenterology 1989; 96: 1165-1172
• 442 Seicean A, Tantau M, Grigorescu M. et al. Mortality risk factors in chronic pancreatitis. J Gastrointestin Liver Dis 2006; 15: 21-26
• 443 Gullo L, Parenti M, Monti L. et al. Diabetic retinopathy in chronic pancreatitis. Gastroenterology 1990; 98: 1577-1581
• 444 Billings BJ, Christein JD, Harmsen WS. et al. Quality-of-life after total pancreatectomy: is it really that bad on long-term follow-up?. J Gastrointest Surg 2005; 9: 1059-1066 ; discussion 1066-1057
• 445 Nakamura T, Imamura K, Takebe K. et al. Diabetic retinopathy in Japanese patients with long-standing pancreatic diabetes due to calcifying pancreatitis. Tohoku J Exp Med 1994; 174: 49-58
• 446 Rosa ESL, Troncon LE, Gallo LJr. et al. Factors associated with abnormal gastric emptying in alcohol-related chronic pancreatitis. J Clin Gastroenterol 2007; 41: 306-311
• 447 Tiengo A, Segato T, Briani G. et al. The presence of retinopathy in patients with secondary diabetes following pancreatectomy or chronic pancreatitis. Diabetes Care 1983; 6: 570-574
• 448 Malka D, Levy P, Bernades P. Thrombotic thrombocytopenic purpura caused by acute pancreatitis in a woman with a pancreas divisum: a case report. Pancreas 1996; 12: 414-416
• 449 Parsaik AK, Murad MH, Sathananthan A. et al. Metabolic and target organ outcomes after total pancreatectomy: Mayo Clinic experience and meta-analysis of the literature. Clin Endocrinol (Oxf) 73: 723-731
• 450 Moran CE, Sosa EG, Martinez SM. et al. Bone mineral density in patients with pancreatic insufficiency and steatorrhea. Am J Gastroenterol 1997; 92: 867-871
• 451 Teichmann J, Mann ST, Stracke H. et al. Alterations of vitamin D3 metabolism in young women with various grades of chronic pancreatitis. Eur J Med Res 2007; 12: 347-350
• 452 Lowenfels AB. Chronic pancreatitis, pancreatic cancer, alcohol, and smoking. Gastroenterology 1984; 87: 744-745
• 453 Ammann RW, Heitz PU, Kloppel G. The "two-hit" pathogenetic concept of chronic pancreatitis. Int J Pancreatol 1999; 25: 251
• 454 Talamini G, Bassi C, Falconi M. et al. Early detection of pancreatic cancer following the diagnosis of chronic pancreatitis. Digestion 1999; 60: 554-561
• 455 Mohan V, Premalatha G, Padma A. et al. Fibrocalculous pancreatic diabetes. Long-term survival analysis. Diabetes Care 1996; 19: 1274-1278
• 456 Rosch T, Schusdziarra V, Born P. et al. Modern imaging methods versus clinical assessment in the evaluation of hospital in-patients with suspected pancreatic disease. Am J Gastroenterol 2000; 95: 2261-2270
• 457 Adler G, Seufferlein T, Bischoff SC. et al. S3-Guidelines "Exocrine pancreatic cancer" 2007. Z Gastroenterol 2007; 45: 487-523
• 458 Tuyns AJ, Pequignot G, Jensen OM. [Esophageal cancer in Ille-et-Vilaine in relation to levels of alcohol and tobacco consumption. Risks are multiplying]. Bull Cancer 1977; 64: 45-60
• 459 Salaspuro MP. Alcohol consumption and cancer of the gastrointestinal tract. Best Pract Res Clin Gastroenterol 2003; 17: 679-694
• 460 Menge BA, Schrader H, Breuer TG. et al. Metabolic consequences of a 50% partial pancreatectomy in humans. Diabetologia 2009; 52: 306-317
• 461 Ozturk E, Can MF, Yagci G. et al. Management and mid- to long-term results of early referred bile duct injuries during laparoscopic cholecystectomy. Hepatogastroenterology 2009; 56: 17-25
• 462 Muller MW, Friess H, Kleeff J. et al. Is there still a role for total pancreatectomy?. Ann Surg 2007; 246: 966-974 ; discussion 974-965
• 463 Linehan IP, Lambert MA, Brown DC. et al. Total pancreatectomy for chronic pancreatitis. Gut 1988; 29: 358-365
• 464 Cooperman AM, Herter FP, Marboe CA. et al. Pancreatoduodenal resection and total pnacreatectomy--an institutional review. Surgery 1981; 90: 707-712
• 465 Benifla M, Weizman Z. Acute pancreatitis in childhood: analysis of literature data. J Clin Gastroenterol 2003; 37: 169-172
• 466 Tomomasa T, Tabata M, Miyashita M. et al. Acute pancreatitis in Japanese and Western children: etiologic comparisons. J Pediatr Gastroenterol Nutr 1994; 19: 109-110
• 467 Darge K, Anupindi S. Pancreatitis and the role of US, MRCP and ERCP. Pediatr Radiol 2009; 39 (Suppl. 02) S153-S157
• 468 Varadarajulu S, Tamhane A, Eloubeidi MA. Yield of EUS-guided FNA of pancreatic masses in the presence or the absence of chronic pancreatitis. Gastrointest Endosc 2005; 62: 728-736 ; quiz 751, 753
• 469 Varadarajulu S, Wilcox CM, Eloubeidi MA. Impact of EUS in the evaluation of pancreaticobiliary disorders in children. Gastrointest Endosc 2005; 62: 239-244
• 470 Attila T, Adler DG, Hilden K. et al. EUS in pediatric patients. Gastrointest Endosc 2009; 70: 892-898
• 471 Manfredi R, Lucidi V, Gui B. et al. Idiopathic chronic pancreatitis in children: MR cholangiopancreatography after secretin administration. Radiology 2002; 224: 675-682
• 472 Hsu RK, Draganov P, Leung JW. et al. Therapeutic ERCP in the management of pancreatitis in children. Gastrointest Endosc 2000; 51: 396-400
• 473 Siegel MJ, Martin KW, Worthington JL. Normal and abnormal pancreas in children: US studies. Radiology 1987; 165: 15-18
• 474 Kugathasan S, Halabi I, Telega G. et al. Pancreatitis as a presenting manifestation of pediatric Crohn's disease: a report of three cases. J Pediatr Gastroenterol Nutr 2002; 35: 96-98
• 475 Ludvigsson JF, Montgomery SM, Ekbom A. Risk of pancreatitis in 14 000 individuals with celiac disease. Clin Gastroenterol Hepatol 2007; 5: 1347-1353
• 476 Witt H, Kage A, Luck W. et al. Alpha1-antitrypsin genotypes in patients with chronic pancreatitis. Scand J Gastroenterol 2002; 37: 356-359
• 477 Gerstner T, Bell N, Konig S. Oral valproic acid for epilepsy--long-term experience in therapy and side effects. Expert Opin Pharmacother 2008; 9: 285-292
• 478 Earl M. Incidence and management of asparaginase-associated adverse events in patients with acute lymphoblastic leukemia. Clin Adv Hematol Oncol 2009; 7: 600-606
• 479 Noone PG, Zhou Z, Silverman LM. et al. Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Gastroenterology 2001; 121: 1310-1319
• 480 Audrezet MP, Chen JM, Le Marechal C. et al. Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis. Eur J Hum Genet 2002; 10: 100-106
• 481 Iqbal CW, Baron TH, Moir CR. et al. Post-ERCP pancreatitis in pediatric patients. J Pediatr Gastroenterol Nutr 2009; 49: 430-434
• 482 Griese M, Dokupil K, Latzin P. Skin prick test reactivity to supplemental enzymes in cystic fibrosis and pancreatic insufficiency. J Pediatr Gastroenterol Nutr 2005; 40: 194-198
• 483 Stallings VA, Stark LJ, Robinson KA. et al. Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review. J Am Diet Assoc 2008; 108: 832-839
• 484 Graff GR, Maguiness K, McNamara J. et al. Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period crossover, superiority study. Clin Ther 2010; 32: 89-103
• 485 DiMagno EP. Gastric acid suppression and treatment of severe exocrine pancreatic insufficiency. Best Pract Res Clin Gastroenterol 2001; 15: 477-486
• 486 Hoffmeister A, Mayerle J, Beglinger C. et al. S3-consensus guidelines on definition, etiology, diagnosis and medical, ensocopic and surgical menagment of chronic pancreatitis; german society of digestive and metabolic diseases (DGVS). Z Gastroenterol 2012; 50: 1176-1224