Ki-67/MIB-1 and Recurrence in Pituitary Adenoma

Kent Tadokoro; Colten Wolf; Joseph Toth; Cara Joyce; Meharvan Singh; Anand Germanwala; Chirag Patel

doi:10.1055/s-0041-1735874

Journal of Neurological Surgery Part B: Skull Base, Table of Contents

J Neurol Surg B Skull Base 2022; 83(S 02): e580-e590
DOI: 10.1055/s-0041-1735874

Original Article

K_i-67/MIB-1 and Recurrence in Pituitary Adenoma

Kent Tadokoro

¹Department of Otolaryngology—Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, United States

,

Colten Wolf

¹Department of Otolaryngology—Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, United States

,

Joseph Toth

²State University of New York Upstate Medical University, Syracuse, New York, United States

,

Cara Joyce

³Department of Biostatistics, Loyola University Stritch School of Medicine, Maywood, Illinois, United States

,

Meharvan Singh

⁴Department of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois United States

,

Anand Germanwala

⁵Department of Neurosurgery, Loyola University Medical Center, Maywood, Illinois, United States

,

Chirag Patel

¹Department of Otolaryngology—Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, United States

› Author Affiliations

Abstract

Objectives K_i-67/MIB-1 is a marker of cellular proliferation used as a pathological parameter in the clinical assessment of pituitary adenomas, where its expression has shown utility in predicting the invasiveness of these tumors. However, studies have shown variable results when using K_i-67/MIB-1 association with recurrence. The purpose of this study is to determine if a high K_i-67/MIB-1 labeling index (LI) is predictive of recurrence in pituitary adenomas.

Methods A retrospective chart review was performed for patients undergoing pituitary adenoma resection with at least 1 year of follow-up. Additionally, systematic data searches were performed and included studies that correlated recurrence rate to K_i-67/MIB-1 LI. Our institutional data were included in a synthesis with previously published data.

Results Our institutional review included 79 patients with a recurrence rate of 26.6%. We found that 8.8% of our patients had a high K_i-67/MIB-1 LI (>3%); however, high K_i-67/MIB-1 was not associated with recurrence. The systematic review identified 244 articles and 49 full-text articles that were assessed for eligibility. Quantitative analysis was performed on 30 articles including our institutional data and 18 studies reported recurrence by level of K_i-67/MIB-1 LI. Among studies that compared K_i-67/MIB-1 ≥3 vs. <3%, 10 studies reported odds ratios (OR) greater than 1 of which 6 were statistically significant. A high K_i-67/MIB-1 had higher odds of recurrence via the pooled odds ratio (OR = 4.15, 95% confidence interval [CI]: 2.31–7.42).

Conclusion This systematic review suggests that a high K_i-67/MIB-1 should prompt an increased duration of follow-up due to the higher odds of recurrence of pituitary adenoma.

Keywords

pituitary adenoma - K_i-67 - MIB-1 - recurrence

Full Text

References

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