Porous Ceramic Sternal Prosthesis Implantation in a 13-Year-Old Patient Presenting with Metastatic Ewing's Sarcoma

Nicolas Mainard; Dyuti Sharma; Damien Fron; Aurélie Mezel; Federico Canavese; Michel Bonnevalle; Eric Nectoux

doi:10.1055/s-0041-1740328

European Journal of Pediatric Surgery Reports, Inhaltsverzeichnis

CC BY 4.0 · European J Pediatr Surg Rep. 2022; 10(01): e1-e5
DOI: 10.1055/s-0041-1740328

Case Report

Porous Ceramic Sternal Prosthesis Implantation in a 13-Year-Old Patient Presenting with Metastatic Ewing's Sarcoma

Nicolas Mainard

¹Department of Pediatric Surgery, Jeanne de Flandre Hospital, Lille, France

,

Dyuti Sharma

¹Department of Pediatric Surgery, Jeanne de Flandre Hospital, Lille, France

²Université Lille 2 Droit et Santé Faculté de Médecine Henri Warembourg, Lille, Hauts-de-France, France

,

Damien Fron

¹Department of Pediatric Surgery, Jeanne de Flandre Hospital, Lille, France

,

Aurélie Mezel

¹Department of Pediatric Surgery, Jeanne de Flandre Hospital, Lille, France

,

Federico Canavese

¹Department of Pediatric Surgery, Jeanne de Flandre Hospital, Lille, France

²Université Lille 2 Droit et Santé Faculté de Médecine Henri Warembourg, Lille, Hauts-de-France, France

,

Michel Bonnevalle

³Department of Pediatric Surgery, Reference Center for Congenital and Malformative Esophageal Disorders, Jeanne de Flandre Children's Hospital, Lille University Faculty of Medicine, Lille, France

,

Eric Nectoux

¹Department of Pediatric Surgery, Jeanne de Flandre Hospital, Lille, France

²Université Lille 2 Droit et Santé Faculté de Médecine Henri Warembourg, Lille, Hauts-de-France, France

› Institutsangaben

Abstract

Ewing's sarcoma is the second most frequent primary malignant bone tumor in adolescents and young adults. Locations on the thoracic wall represent up to 20% of primary and secondary locations. We present the case of a 13-year-old patient treated with the use of a radiolucency porous bioceramic prosthesis as a sternal replacement for a wide tumor resection in an oncologic context. Focal radiation therapy was not possible due to the high risk of severe myocardial injuries caused by the sternal location of the tumor. The sternum CERAMIL® (I.CERAM, Limoges, France), in porous alumina (Al₂O₃) has already been implanted into adults in sternal replacement during its invasion by a tumor or its infectious destruction. There were no complication concerning the surgery. The last follow-up at 2 years postoperatively reveals a satisfactory clinical situation with any functional thoracic complaint and nor any functional respiratory symptoms. The porous alumina sternal prosthesis offers a reliable alternative for sternal replacement indications for children in an oncologic context.

Keywords

Ewing's sarcoma - sternum - prosthesis - bioceramics - tissue engineering

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Referenzen

References
1 Balamuth NJ, Womer RB. Ewing's sarcoma. Lancet Oncol 2010; 11 (02) 184-192
2 Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res 2007; 459 (459) 40-47
3 Lacour B, Guyot-Goubin A, Guissou S, Bellec S, Désandes E, Clavel J. Incidence of childhood cancer in France: National Children Cancer Registries, 2000-2004. Eur J Cancer Prev 2010; 19 (03) 173-181
4 Bosma SE, Ayu O, Fiocco M, Gelderblom H, Dijkstra PDS. Prognostic factors for survival in Ewing sarcoma: a systematic review. Surg Oncol 2018; 27 (04) 603-610
5 Saenz NC, Hass DJ, Meyers P. et al. Pediatric chest wall Ewing's sarcoma. J Pediatr Surg 2000; 35 (04) 550-555
6 Baino F, Novajra G, Vitale-Brovarone C. Bioceramics and scaffolds: a winning combination for tissue engineering. Front Bioeng Biotechnol 2015; 3: 202
7 Galbis Caravajal JM, Yeste Sánchez L, Fuster Diana CA, Guijarro Jorge R, Fernández Ortiz P, Deaville PJ. Sternal resection and reconstruction after malignant tumours. Clin Transl Oncol 2009; 11 (02) 91-95
8 Kaláb M, Karkoška J, Kamínek M. et al. Reconstruction of massive post-sternotomy defects with allogeneic bone graft: four-year results and experience using the method. Interact Cardiovasc Thorac Surg 2016; 22 (03) 305-313
9 Skoracki RJ, Chang DW. Reconstruction of the chestwall and thorax. J Surg Oncol 2006; 94 (06) 455-465
10 Seder CW, Rocco G. Chest wall reconstruction after extended resection. J Thorac Dis 2016; 8 (Suppl. 11) S863-S871
11 Sanna S, Brandolini J, Pardolesi A. et al. Materials and techniques in chest wall reconstruction: a review. J Vis Surg 2017; 3: 95
12 Bertin F, Piccardo A, Denes E, Delepine G, Tricard J. Porous alumina ceramic sternum: a reliable option for sternal replacement. Ann Thorac Med 2018; 13 (04) 226-229
13 Fouilloux V, Bertin F, Peltier E, Jouve JL. First sternal cleft repair using a porous alumina ceramic prosthesis in a 9-year-old child. European J Pediatr Surg Rep 2019; 7 (01) e20-e23
14 Denes E, Barrière G, Poli E, Lévêque G. Commentary: bioceramics and scaffolds: a winning combination for tissue engineering. Front Bioeng Biotechnol 2017; 5 (02) 15
15 Cotterill SJ, Ahrens S, Paulussen M. et al. Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol 2000; 18 (17) 3108-3114
16 Poli E, Ouk TS, Barrière G, Lévèque G, Sol V, Denes E. Does low hydroxyl group surface density explain less bacterial adhesion on porous alumina?. Orthop Traumatol Surg Res 2019; 105 (03) 473-477
17 Slullitel PA, Buttaro MA, Greco G. et al. No lower bacterial adhesion for ceramics compared to other biomaterials: an in vitro analysis. Orthop Traumatol Surg Res 2018; 104 (04) 439-443