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Endosc Int Open 2016; 04(05): E597-E602
DOI: 10.1055/s-0042-105202
Original article
© Georg Thieme Verlag KG Stuttgart · New York

Change in gastric emptying eight weeks after endoscopic submucosal dissection in patients with early gastric cancer

Ko Watanabe
1   Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima City, Japan
2   Department of Endoscopy, Fukushima Medical University Hospital, Fukushima City, Japan
,
Takuto Hikichi
2   Department of Endoscopy, Fukushima Medical University Hospital, Fukushima City, Japan
,
Masaki Sato
1   Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima City, Japan
,
Jun Nakamura
1   Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima City, Japan
,
Katsutoshi Obara
3   Department of Advanced Gastroenterological Endoscopy, Fukushima Medical University, Fukushima City, Japan
,
Hiromasa Ohira
1   Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima City, Japan
› Author Affiliations
Further Information

Publication History

submitted 31 August 2015

accepted after revision 21 February 2016

Publication Date:
21 April 2016 (online)

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Background: Gastric emptying after endoscopic submucosal dissection (ESD) for early gastric cancer is not clear. The aim of this study was to evaluate changes in gastric emptying from before ESD to 8 weeks after ESD.

Methods: In total, 54 patients with early gastric cancer were enrolled in this study. A breath test with carbon 13 (13C) was conducted before ESD and at 1 and 8 weeks after ESD. The Tlag and T1/2 values were analyzed at each time point. The primary outcomes were the changes in the Tlag and T1/2 values from before ESD to 1 and 8 weeks after ESD. The secondary outcomes were the factors associated with the changes in the Tlag and T1/2 values.

Results: Gastric emptying was delayed at 1 and 8 weeks after ESD compared with before ESD (Tlag P = 0.002, P < 0.001; T1/2 P = 0.005, P = 0.001, respectively). The changes in the Tlag and T1/2 values from before ESD to 1 week after ESD were greater for proximal stomach lesions than for distal stomach lesions (P = 0.028, P < 0.001). Proximal stomach lesions were identified as the significant factor that influenced changes in the Tlag and T1/2 values from before ESD to 1 week after ESD in the multivariate analyses (Tlag P = 0.003, T1/2 P = 0.005).

Conclusions: ESD induced delayed gastric emptying until 8 weeks after ESD. Proximal stomach lesions were also associated with decreased emptying 1 week after ESD.

 

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