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Aktuelle Dermatologie 2016; 42(08/09): 357-359
DOI: 10.1055/s-0042-108019
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Classical Case of Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type

Fallbericht eines primär kutanen diffusen großzelligen B-Zell-Lymphoms
V. Lauryne
1   Department of Skin and Venereal Diseases, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania
,
J. Karciauskiene
1   Department of Skin and Venereal Diseases, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania
,
J. Makstiene
2   Department of Pathological Anatomy, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania
,
V. Kucinskiene
1   Department of Skin and Venereal Diseases, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania
,
S. Valiukeviciene
1   Department of Skin and Venereal Diseases, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
06. Juni 2016 (online)

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Abstract

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) usually occurs in elderly patients and in most cases affects lower legs. A 76-year old man presented with red-brown coloured patches and plaques with irregular borders and multiple firm nodes on the anterior surface of the right lower leg. The excision biopsy of a node and histological examination has confirmed the diagnosis of PCDLBCL-LT. Clinical, laboratory and radiological examination showed no evidence of systemic involvement. The treatment was started with R-CHOP (rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone) regimen. The patient died within 10 months due to cardiac complications since the initial diagnosis.

Zusammenfassung

Das primäre kutane diffuse großzellige B-Zell-Lymphom, Unterschenkeltyp (PCDLBCL-LT) tritt bei älteren Patienten auf und fast immer an den Unterschenkeln. Ein 76-jähriger älterer Herr stellte sich mit rot-braunen Makeln und Plaques mit unregelmäßiger Begrenzung und mehreren indurierten Knoten am Schienbein des rechten Unterschenkels vor. Die Exzisionsbiopsie eines Knotens und die histologische Untersuchung bestätigten die Diagnose eines PCDLBCL-LT. Klinische, laborchemische und radiologische Untersuchungen zeigten keine Evidenz für eine systemische Beteiligung. Die Behandlung startete mit einem R-CHOP-Schema (Rituximab-Cyclophosphamid, Doxorubicin, Vincristin und Prednisolon). Der Patient verstarb aufgrund von kardialen Komplikationen 10 Monate nach Diagnosestellung.

 

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