Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000007.xml
Aktuelle Urol 2016; 47(05): 347-348
DOI: 10.1055/s-0042-111911
DOI: 10.1055/s-0042-111911
Referiert und kommentiert
Testosteronmangel – TRT vermindert kardiovaskuläre Ereignisse
Further Information
Publication History
Publication Date:
05 October 2016 (online)
Eine Testosteronersatztherapie (testosterone replacement therapy, TRT) kann indiziert sein, wenn laborchemisch ein Hypogonadismus vorliegt und Symptome eines Testosteronmangels nachweisbar sind. Allerdings sind die Auswirkungen der TRT auf das kardiovaskuläre System unklar, und ein erhöhtes Risiko für Myokardinfarkte wird diskutiert. Sharma et al. haben eine umfangreiche Datensammlung dazu vorgelegt.
Eur Heart J 2015; 36: 2706–2715
-
Literatur
- 1 FDA. FDA Drug Safety Communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use. Im Internet http://www.fda.gov/Drugs/DrugSafety/ucm436259.htm
- 2 Basaria S, Coviello AD, Travison TG et al. Adverse Events Associated with Testosterone Administration. NEJM 2010; 363: 109-122
- 3 Baillargeon J, Urban RJ, Kuo YF et al. Risk of Myocardial Infarction in Older Men Receiving Testosterone Therapy. Ann Pharmacother 2014; 48: 1138-1144
- 4 Finkle WD, Greenland S, Ridgeway GK et al. Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men. PLoS ONE. 2014; 9 e85805
- 5 Muraleedharan V, Marsh H, Kapoor D et al. Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes. Eur J Endocrinol 2013; 169: 725-733
- 6 Shores MM, Smith NL, Forsberg CW et al. Testosterone Treatment and Mortality in Men with Low Testosterone Levels. Journal Clin Endocrinol Metab 2012; 97: 2050-2058
- 7 Vigen R, O’Donnell CI, Barón AE et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA 2013; 310: 1829-1836
- 8 Von Drehle D. Manopause?! Aging, insecurity and the 2 billion testosterone industry. Im Internet http://time.com/3062889/manopause-aging-insecurity-and-the-2-billion-testosterone-industry/
- 9 Vigen R, O‘Donell CI, Barón AE et al. Correction: Incorrect number of excluded patients reported in the text and figure. JAMA 2014; 311: 967
- 10 Snyder PJ, Bhasin S, Cunningham GR et al. Effects of Testosterone Treatment in Older Men. NEJM 2016; 374: 611-624