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CC BY-NC-ND 4.0 · Journal of Health and Allied Sciences NU 2022; 12(04): 454-458
DOI: 10.1055/s-0042-1742367
Brief Report

A Preliminary Assessment of Tinospora sinensis on Mice Liver

Autor*innen

  • Abidah Parveen 

    1   Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, United States
    2   National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, United States
    3   Department of Pharmaceutical Sciences, Abbottabad University of Science and Technology, Havelian, Khyber Pakhtunkhwa, Pakistan

  • Tahir Maqbool Mir 

    2   National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, United States

  • Zulfiqar Ali

    2   National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, United States

  • Ikhlas A. Khan

    1   Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, University of Mississippi, University, MS, United States
    2   National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, United States

  • M. Khalid Ashfaq

    2   National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS, United States
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Abstract

Objective A preliminary study was conducted to assess the role of Tinospora sinensis extract on liver in mice in normal and lipopolysaccharide (LPS)-induced health-compromised conditions.

Method Mice (n = 3–5) were randomly assigned into groups I to IV for hepatotoxic studies. Group I was assigned normal, group II was given LPS (6 mg/kg, intraperitoneal [ip]), group III was given T. sinensis only (1 g/kg/day for 21 days), whereas group IV was administered T. sinensis (1 g/kg/day per os [po] for 21 days) with LPS (6 mg/kg ip given on 7th day). Group V received monocrotaline (MCT) (200 mg/kg, p.o.) only. Group VI received MCT (200 mg/kg, po) and LPS (6 mg/kg ip). Group VII was given T. sinensis (500 mg/kg/day po for 7 days) followed by MCT (200 mg/kg, p.o.) and LPS (6 mg/kg, ip) on the 7th day. Groups V to VII were used to assess the effect of T. sinensis in MCT + LPS-induced hepatotoxicity model.

Results No elevation in alanine transaminase (ALT) levels was observed in mice treated with T. sinensis in group III or group IV compared with normal (vehicle treated) group (group I). Elevation in ALT levels was observed in group VI (MCT + LPS) and group VII; histopathology showed liver injury. Pretreatment of mice with T. sinensis (group VII) did not show any reduction in the elevated ALT levels.

Conclusions In the preliminary assessment, T. sinensis extract was found to exhibit neither hepatotoxicity itself nor the potential to thwart liver damage by a xenobiotic under the given test conditions, dosage, and duration of the study.

Keywords

Tinospora sinensis - extract - lipopolysaccharide - xenobiotic


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Artikel online veröffentlicht:
15. Februar 2022

© 2022. Nitte (Deemed to be University). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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