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Semin Plast Surg 2022; 36(01): 048-052
DOI: 10.1055/s-0042-1742748
Review Article

The Use of Biologic Wound Agents in Pediatric Reconstructions

Jessica M. May
1   Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas
,
Monal Depani
1   Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas
,
Andrew M. Ferry
2   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
3   Division of Plastic Surgery, Department of Surgery, Texas Children's Hospital, Houston, Texas
,
John C. Koshy
2   Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas
3   Division of Plastic Surgery, Department of Surgery, Texas Children's Hospital, Houston, Texas
,
James F. Thornton
1   Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas
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Abstract

The indications for using biologic wound agents have expanded greatly since first being employed for acute burn management. The majority of the literature details the use of said agents in the adult population; however, there is little representation regarding their uses for reconstructing defects typically observed in the pediatric population. Ironically, children, and to a lesser extent adolescents, greatly benefit from their use given the reduced skin laxity and amount of surrounding tissue available for locoregional tissue transfer when compared with adults. Herein, we detail the use of acellular and cellular biologic wound agents in the pediatric population.

Keywords

plastic surgery - pediatrics - Integra - AlloDerm - TheraSkin - wound healing - biologic wound agents


Publication History

Article published online:
25 February 2022

© 2022. Thieme. All rights reserved.

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  • References

  • 1 Vyas KS, Vasconez HC. Wound healing: biologics, skin substitutes, biomembranes and scaffolds. Healthcare (Basel) 2014; 2 (03) 356-400
    CrossrefPubMedSearch in Google Scholar
  • 2 Oh C, Winocour SJ, Lemaine V. Latest trends in subpectoral breast reconstruction. Semin Plast Surg 2019; 33 (04) 224-228
    Thieme ConnectPubMedSearch in Google Scholar
  • 3 Ferry AM, Sarrami SM, Hollier PC, Gerich CF, Thornton JF. Treatment of non-melanoma skin cancers in the absence of Mohs micrographic surgery. Plast Reconstr Surg Glob Open 2020; 8 (12) e3300
    CrossrefPubMedSearch in Google Scholar
  • 4 Dantzer E, Braye FM. Reconstructive surgery using an artificial dermis (Integra): results with 39 grafts. Br J Plast Surg 2001; 54 (08) 659-664
    CrossrefPubMedSearch in Google Scholar
  • 5 Braun TL, Hamilton KL, Monson LA, Buchanan EP, Hollier Jr LH. Tissue expansion in children. Semin Plast Surg 2016; 30 (04) 155-161
    Thieme ConnectPubMedSearch in Google Scholar
  • 6 Sarrami SM, Ferry AM, Buchanan EP, Gerow FT, Koshy JC. Reconstructing severe lower extremity skin necrosis in a pediatric patient. Adv Skin Wound Care 2021; 34 (07) 1-6
    CrossrefPubMedSearch in Google Scholar
  • 7 Silberstein E, Pagkalos VA, Landau D. et al. Aplasia cutis congenita: clinical management and a new classification system. Plast Reconstr Surg 2014; 134 (05) 766e-774e
    CrossrefPubMedSearch in Google Scholar
  • 8 Aldekhayel SA, Sinno H, Gilardino MS. Acellular dermal matrix in cleft palate repair: an evidence-based review. Plast Reconstr Surg 2012; 130 (01) 177-182
    CrossrefPubMedSearch in Google Scholar
  • 9 Achauer BM, VanderKam VM, Celikoz B, Jacobson DG. Augmentation of facial soft-tissue defects with Alloderm dermal graft. Ann Plast Surg 1998; 41 (05) 503-507
    CrossrefPubMedSearch in Google Scholar
  • 10 Kumbla PA, Yuen JC, Tait MA. Applying a dermal regenerative template in management of congenital melanocytic nevi of the hand. Plast Reconstr Surg Glob Open 2015; 3 (09) e515
    CrossrefPubMedSearch in Google Scholar
  • 11 Grunwaldt LJ, Adetayo OA, MacIsaac ZM, Losee JE, Kumar AR. Successful reconstruction of complex pediatric nasal lesions: improving outcomes using dermal regenerative templates. Plast Reconstr Surg Glob Open 2014; 2 (02) e107
    CrossrefPubMedSearch in Google Scholar
  • 12 Weathers WM, Bhadkamkar M, Wolfswinkel EM, Thornton JF. Full-thickness skin grafting in nasal reconstruction. Semin Plast Surg 2013; 27 (02) 90-95
    Thieme ConnectPubMedSearch in Google Scholar
  • 13 Berezovsky AB, Pagkalos VA, Silberstein E, Shoham Y, Rosenberg L, Krieger Y. Primary contraction of skin grafts: a porcine preliminary study. Plast Aesthetic Res 2015; 2: 22-26
    CrossrefPubMedSearch in Google Scholar
  • 14 Seth AK, Ratanshi I, Dayan JH, Disa JJ, Mehrara BJ. Nasal reconstruction using the Integra Dermal Regeneration Template. Plast Reconstr Surg 2019; 144 (04) 966-970
    CrossrefPubMedSearch in Google Scholar
  • 15 Callcut RA, Schurr MJ, Sloan M, Faucher LD. Clinical experience with Alloderm: a one-staged composite dermal/epidermal replacement utilizing processed cadaver dermis and thin autografts. Burns 2006; 32 (05) 583-588
    CrossrefPubMedSearch in Google Scholar
  • 16 Munster AM, Smith-Meek M, Shalom A. Acellular allograft dermal matrix: immediate or delayed epidermal coverage?. Burns 2001; 27 (02) 150-153
    CrossrefPubMedSearch in Google Scholar
  • 17 Richardson S, Hoyt JS, Khosla RK, Khandeparker RVS, Sukhadia VY, Agni N. Use of regenerative tissue matrix as an oral layer for the closure of recalcitrant anterior palatal fistulae: a pilot study. J Korean Assoc Oral Maxillofac Surg 2016; 42 (02) 77-83
    CrossrefPubMedSearch in Google Scholar
  • 18 Kirschner RE, Cabiling DS, Slemp AE, Siddiqi F, LaRossa DD, Losee JE. Repair of oronasal fistulae with acellular dermal matrices. Plast Reconstr Surg 2006; 118 (06) 1431-1440
    CrossrefPubMedSearch in Google Scholar
  • 19 Dibbs RP, Beh HZ, Ferry AM. et al. Two-stage treatment of a large premaxillary defect. J Craniofac Surg 2021; 32 (08) 2827-2829
    CrossrefPubMedSearch in Google Scholar
  • 20 Broyles JM, Abt NB, Sacks JM, Butler CE. Bioprosthetic tissue matrices in complex abdominal wall reconstruction. Plast Reconstr Surg Glob Open 2014; 1 (09) e91
    CrossrefPubMedSearch in Google Scholar
  • 21 Butler CE, Langstein HN, Kronowitz SJ. Pelvic, abdominal, and chest wall reconstruction with AlloDerm in patients at increased risk for mesh-related complications. Plast Reconstr Surg 2005; 116 (05) 1263-1275 , discussion 1276–1277
    CrossrefPubMedSearch in Google Scholar
  • 22 Lambropoulos V, Mylona E, Mouravas V. et al. Repair of postoperative abdominal hernia in a child with congenital omphalocele using porcine dermal matrix. Case Rep Med 2016; 2016: 1828751
    CrossrefPubMedSearch in Google Scholar
  • 23 Alaish SM, Strauch ED. The use of Alloderm in the closure of a giant omphalocele. J Pediatr Surg 2006; 41 (03) e37-e39
    CrossrefPubMedSearch in Google Scholar
  • 24 Kapfer SA, Keshen TH. The use of human acellular dermis in the operative management of giant omphalocele. J Pediatr Surg 2006; 41 (01) 216-220
    CrossrefPubMedSearch in Google Scholar
  • 25 Ferry AM, Beh HZ, Truong LA. et al. Management of bilateral temporomandibular joint ankylosis and class 2 malocclusion in a patient with Nager syndrome. FACE 2021; 2 (04) 484-489
    CrossrefPubMedSearch in Google Scholar
  • 26 Gurtner GC, Garcia AD, Bakewell K, Alarcon JB. A retrospective matched-cohort study of 3994 lower extremity wounds of multiple etiologies across 644 institutions comparing a bioactive human skin allograft, TheraSkin, plus standard of care, to standard of care alone. Int Wound J 2020; 17 (01) 55-64
    CrossrefPubMedSearch in Google Scholar
  • 27 Barbul A, Gurtner GC, Gordon H, Bakewell K, Carter MJ. Matched-cohort study comparing bioactive human split-thickness skin allograft plus standard of care to standard of care alone in the treatment of diabetic ulcers: a retrospective analysis across 470 institutions. Wound Repair Regen 2020; 28 (01) 81-89
    CrossrefPubMedSearch in Google Scholar
  • 28 Landsman A, Rosines E, Houck A. et al. Characterization of a cryopreserved split-thickness human skin allograft-TheraSkin. Adv Skin Wound Care 2016; 29 (09) 399-406
    CrossrefPubMedSearch in Google Scholar