Use of Biologic Agents in Extremity Reconstruction

Andrew E. Grush; Monal Depani; Matthew J. Parham; Valeria Mejia-Martinez; Alexandra Thornton; Douglas M. Sammer

doi:10.1055/s-0042-1744282

Seminars in Plastic Surgery, Table of Contents

Semin Plast Surg 2022; 36(01): 043-047
DOI: 10.1055/s-0042-1744282

Review Article

Use of Biologic Agents in Extremity Reconstruction

Andrew E. Grush

¹Michael E. DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas

²Department of Surgery, Division of Plastic Surgery, Texas Children's Hospital, Houston, Texas

,

Monal Depani

³Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas

,

Matthew J. Parham

¹Michael E. DeBakey Department of Surgery, Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas

²Department of Surgery, Division of Plastic Surgery, Texas Children's Hospital, Houston, Texas

,

Valeria Mejia-Martinez

³Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas

,

Alexandra Thornton

³Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas

,

Douglas M. Sammer

³Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas

› Author Affiliations

Abstract

Skin and soft tissue defects of the lower extremity present a unique challenge for the reconstructive surgeon. Successful repair of the lower extremity relies not only on strong anatomical knowledge and surgical expertise, but also on careful consideration of the numerous preoperative factors and indications that may alter the patient's response to operative management. While many of these injuries result from burns, avulsive trauma, diabetes, or vascular insufficiencies, a significant portion can be associated with resection of neoplastic pathologies. This review outlines the uses, indications, and considerations for biologic wound agents in reconstructing skin and soft tissue defects of the lower extremity following Mohs micrographic surgery.

Keywords

Mohs micrographic surgery - lower extremity - Integra - fasciocutaneous flap - melanoma - cutaneous malignancies

Full Text

References

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