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DOI: 10.1055/s-0042-1751416
Bioinspired Total Syntheses of Gymnothelignans
We acknowledge the financial support from the National Natural Science Foundation of China (NSFC) (22171115, 21901093, 22231003, 21732001, 21871118, 22071090), Ministry of Education (MOE) (IRT_15R28), State Key Laboratory of Applied Organic Chemistry (SKLAOC), Lanzhou University (LZU) for the Fundamental Research Funds for the Central Universities (lzujbky-2022-58), and the Science and Technology Department of Gansu Province (22JR5RA397).
Abstract
Since 2012, Xu and Zhou have reported the isolation of a series of gymnotheligans, a large group of novel tetrahydrofuran-containing lignan natural products. In the past decade, considerable achievements in the total syntheses of these lignans have been achieved based on a plausible biogenetic pathway proposed by our group in 2014. In this account, we summarize these remarkable synthetic works of the past ten years.
1 Introduction
2 Biogenetic Pathways to Gymnothelignans
3 Total Syntheses of Eupodienones
4 Total Syntheses of Eupomatilones
5 Total Synthesis of Dibenzocyclooctenes
6 Conclusions
Key words
total synthesis - biogenetic pathway - gymnothelignans - eupodienone - eupomatilone - dibenzocyclooctenePublication History
Received: 25 December 2022
Accepted after revision: 18 January 2023
Article published online:
09 February 2023
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