Abstract
Over the past two decades, bioorthogonal chemistry has profoundly impacted various
chemistry-related fields, including chemical biology and drug delivery. This transformative
progress stems from collaborative efforts involving chemists and biologists, underscoring
the importance of interdisciplinary research. In this Account, we present the developments
in bioorthogonal chemistry within our Institute for Molecules and Materials at Radboud
University. The chemistry disclosed here spans from strained alkynes and alkenes to
drug release and bioconjugation strategies, mirroring the extensive scope provided
by bioorthogonal chemistry. By reflecting on the chemistry originating at Radboud
University, this Account emphasizes that teamwork is essential for driving significant
progress in bioorthogonal chemistry.
1 Introduction
2 Providing BCN as a Robust Bioorthogonal Tool for Chemical Biology and Beyond
3 Towards Readily Available Click-to-Release trans-Cyclooctenes
4 Giving Molecules Guidance
5 Next Generation of Bioconjugation Strategies: Dynamic Click Chemistry
6 Conclusions
Keywords
bioorthogonal chemistry - chemical biology - strained alkynes - tetrazines - drug
activation
