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Synlett 2024; 35(01): 113-117
DOI: 10.1055/s-0042-1752654
DOI: 10.1055/s-0042-1752654
cluster
Functional Dyes
Photooxidative Coupling of Thiols Promoted by Bromo(trichloro)methane in a Basic Aqueous Medium
This work was supported by Nanjing Tech University (Start-up Grants Nos. 38274017101 and 3827401742).
Abstract
A transition-metal- and organic-solvent-free oxidative coupling of thiols catalyzed by BrCCl3 and NaOH in an aqueous medium with oxygen as a green oxidant was established The facile and green method has a broad substrate scope in converting thiols into the corresponding disulfides with medium to excellent yields (up to 91%). This method could potentially be used to construct bioactive molecules containing disulfide bonds and to label bioactive molecules with disulfide bonds.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1752654.
- Supporting Information
Publication History
Received: 14 January 2023
Accepted: 17 February 2023
Article published online:
31 March 2023
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