PDF herunterladen
Semin Neurol 2022; 42(04): 441-448
DOI: 10.1055/s-0042-1757929
Review Article

Migraine and Posttraumatic Headache: Similarities and Differences in Brain Network Connectivity

Catherine D. Chong 
1   Department of Neurology, Mayo Clinic, Phoenix, Arizona
,
Jennifer Nikolova
2   University of Northern British Columbia, BC, Canada
,
Gina M. Dumkrieger
1   Department of Neurology, Mayo Clinic, Phoenix, Arizona
› Institutsangaben
› Weitere Informationen
    Lizenzen und Reprints

Abstract

Posttraumatic headache (PTH) is the most common symptom following mild traumatic brain injury (mTBI) (also known as concussion). Migraine and PTH have similar phenotypes, and a migraine-like phenotype is common in PTH. The similarities between both headache types are intriguing and challenge a better understanding of the pathophysiological commonalities involved in migraine and PTH due to mTBI. Here, we review the PTH resting-state functional connectivity literature and compare it to migraine to assess overlap and differences in brain network function between both headache types. Migraine and PTH due to mTBI have overlapping and disease-specific widespread alterations of static and dynamic functional networks involved in pain processing as well as dysfunctional network connections between frontal regions and areas of pain modulation and pain inhibition. Although the PTH functional network literature is still limited, there is some evidence that dysregulation of the top-down pain control system underlies both migraine and PTH. However, disease-specific differences in the functional circuitry are observed as well, which may reflect unique differences in brain architecture and pathophysiology underlying both headache disorders.

Keywords

migraine - posttraumatic headache - mild traumatic brain injury - hypothalamus - periaqueductal gray - static and dynamic functional connectivity


Publikationsverlauf

Artikel online veröffentlicht:
02. November 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Yilmaz T, Roks G, de Koning M. et al. Risk factors and outcomes associated with post-traumatic headache after mild traumatic brain injury. Emerg Med J 2017; 34 (12) 800-805
    CrossrefPubMedGoogle Scholar
  • 2 Hoffman JM, Lucas S, Dikmen S. et al. Natural history of headache after traumatic brain injury. J Neurotrauma 2011; 28 (09) 1719-1725
    CrossrefPubMedGoogle Scholar
  • 3 Walker WC, Marwitz JH, Wilk AR. et al. Prediction of headache severity (density and functional impact) after traumatic brain injury: a longitudinal multicenter study. Cephalalgia 2013; 33 (12) 998-1008
    CrossrefPubMedGoogle Scholar
  • 4 Minen MT, Boubour A, Walia H, Barr W. Post-concussive syndrome: a focus on post-traumatic headache and related cognitive, psychiatric, and sleep issues. Curr Neurol Neurosci Rep 2016; 16 (11) 100
    CrossrefPubMedGoogle Scholar
  • 5 Ashina H, Al-Khazali HM, Iljazi A. et al. Psychiatric and cognitive comorbidities of persistent post-traumatic headache attributed to mild traumatic brain injury. J Headache Pain 2021; 22 (01) 83
    CrossrefPubMedGoogle Scholar
  • 6 Kim SK, Chong CD, Dumkrieger G, Ross K, Berisha V, Schwedt TJ. Clinical correlates of insomnia in patients with persistent post-traumatic headache compared with migraine. J Headache Pain 2020; 21 (01) 33
    CrossrefPubMedGoogle Scholar
  • 7 Dumkrieger G, Chong CD, Ross K, Berisha V, Schwedt TJ. Static and dynamic functional connectivity differences between migraine and persistent post-traumatic headache: a resting-state magnetic resonance imaging study. Cephalalgia 2019; 39 (11) 1366-1381
    CrossrefPubMedGoogle Scholar
  • 8 Li F, Lu L, Shang S. et al. Altered static and dynamic functional network connectivity in post-traumatic headache. J Headache Pain 2021; 22 (01) 137
    CrossrefPubMedGoogle Scholar
  • 9 Zou Y, Tang W, Qiao X, Li J. Aberrant modulations of static functional connectivity and dynamic functional network connectivity in chronic migraine. Quant Imaging Med Surg 2021; 11 (06) 2253-2264
    CrossrefPubMedGoogle Scholar
  • 10 Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A 2001; 98 (02) 676-682
    CrossrefPubMedGoogle Scholar
  • 11 Seeley WW, Menon V, Schatzberg AF. et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 2007; 27 (09) 2349-2356
    CrossrefPubMedGoogle Scholar
  • 12 Schulte LH, May A. Of generators, networks and migraine attacks. Curr Opin Neurol 2017; 30 (03) 241-245
    CrossrefPubMedGoogle Scholar
  • 13 Schulte LH, Menz MM, Haaker J, May A. The migraineur's brain networks: Continuous resting state fMRI over 30 days. Cephalalgia 2020; 40 (14) 1614-1621
    CrossrefPubMedGoogle Scholar
  • 14 Schulte LH, May A. The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 2016; 139 (Pt 7): 1987-1993
    CrossrefPubMedGoogle Scholar
  • 15 Lu L, Li F, Wang P, Chen H, Chen YC, Yin X. Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury. J Headache Pain 2020; 21 (01) 93
    CrossrefPubMedGoogle Scholar
  • 16 Messina R, Rocca MA, Valsasina P, Misci P, Filippi M. Clinical correlates of hypothalamic functional changes in migraine patients. Cephalalgia 2021; 42 (4-5): 279-290
    CrossrefPubMedGoogle Scholar
  • 17 Coppola G, Di Renzo A, Petolicchio B. et al. Increased neural connectivity between the hypothalamus and cortical resting-state functional networks in chronic migraine. J Neurol 2020; 267 (01) 185-191
    CrossrefPubMedGoogle Scholar
  • 18 Moulton EA, Becerra L, Johnson A, Burstein R, Borsook D. Altered hypothalamic functional connectivity with autonomic circuits and the locus coeruleus in migraine. PLoS One 2014; 9 (04) e95508
    CrossrefPubMedGoogle Scholar
  • 19 Gecse K, Dobos D, Aranyi CS. et al. Association of plasma tryptophan concentration with periaqueductal gray matter functional connectivity in migraine patients. Sci Rep 2022; 12 (01) 739
    CrossrefPubMedGoogle Scholar
  • 20 Gecse K, Baksa D, Dobos D. et al. Sex differences of periaqueductal grey matter functional connectivity in migraine. Front Pain Res (Lausanne) 2021; 2: 767162
    CrossrefPubMedGoogle Scholar
  • 21 Jang SH, Park SM, Kwon HG. Relation between injury of the periaqueductal gray and central pain in patients with mild traumatic brain injury: Observational study. Medicine (Baltimore) 2016; 95 (26) e4017
    CrossrefPubMedGoogle Scholar
  • 22 Linnman C, Moulton EA, Barmettler G, Becerra L, Borsook D. Neuroimaging of the periaqueductal gray: state of the field. Neuroimage 2012; 60 (01) 505-522
    CrossrefPubMedGoogle Scholar
  • 23 Nikolova S, Schwedt TJ, Chong CD. T2* reduction in patients with acute post-traumatic headache. Cephalalgia 2021. Doi: 3331024211048509
    PubMedGoogle Scholar
  • 24 Niu X, Bai L, Sun Y. et al. Disruption of periaqueductal grey-default mode network functional connectivity predicts persistent post-traumatic headache in mild traumatic brain injury. J Neurol Neurosurg Psychiatry 2019; 90 (03) 326-332
    CrossrefPubMedGoogle Scholar
  • 25 Chen Z, Chen X, Liu M, Liu S, Ma L, Yu S. Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine. J Headache Pain 2017; 18 (01) 36
    CrossrefPubMedGoogle Scholar
  • 26 Li Z, Liu M, Lan L. et al. Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment. Sci Rep 2016; 6: 20298
    CrossrefPubMedGoogle Scholar
  • 27 Mainero C, Boshyan J, Hadjikhani N. Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine. Ann Neurol 2011; 70 (05) 838-845
    CrossrefPubMedGoogle Scholar
  • 28 Solstrand Dahlberg L, Linnman CN, Lee D, Burstein R, Becerra L, Borsook D. Responsivity of periaqueductal gray connectivity is related to headache frequency in episodic migraine. Front Neurol 2018; 9: 61
    CrossrefPubMedGoogle Scholar
  • 29 Young WB, Park JE, Tian IX, Kempner J. The stigma of migraine. PLoS One 2013; 8 (01) e54074
    CrossrefPubMedGoogle Scholar