Semin intervent Radiol 2022; 39(04): 411-415
DOI: 10.1055/s-0042-1758076
Review Article

Oncopharmacology in Interventional Radiology

Junaid Raja
1   Division of Interventional Radiology, University of Alabama at Birmingham, Birmingham, Alabama
,
David C. Madoff
2   Division of Interventional Radiology, Yale New Haven Hospital, New Haven, Connecticut
› Institutsangaben

Abstract

The broad scope of malignancies treated in interventional oncology is mirrored by the breadth of oncotherapeutics, drugs used to treat cancer. Many of these treatments are administered endovascularly, though a group of therapies can be delivered percutaneously. Perhaps the best taxonomy of oncotherapeutics is based on their biological inactivity or activity and the mechanism by which they interact with treated and targeted tissues. As the fields of interventional oncology and oncotherapeutics continue to grow and expand, this framework may provide a more organized approach in helping distinguish and select the best therapy for patients.



Publikationsverlauf

Artikel online veröffentlicht:
17. November 2022

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  • References

  • 1 Ramsey DE, Kernagis LY, Soulen MC, Geschwind JF. Chemoembolization of hepatocellular carcinoma. J Vasc Interv Radiol 2002; 13 (9, Pt 2): S211-S221
  • 2 Van Ha TG. Transarterial chemoembolization for hepatocellular carcinoma. Semin Intervent Radiol 2009; 26: 270-275
  • 3 Marelli L, Stigliano R, Triantos C. et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol 2007; 30 (01) 6-25
  • 4 Case MD, Slovak R, Raja J, Kim HS. Interventional Oncology in Immuno-Oncology Part 2: Transcatheter therapies. Dig Dis Interv 2019; 03 (02) 155-162
  • 5 Sheth RA, Sabir S, Krishnamurthy S. et al. Endovascular embolization by transcatheter delivery of particles: past, present, and future. J Funct Biomater 2017; 8 (02) 12
  • 6 Desai KR, Chen RI. Endovascular therapy for palliative care of cancer patients. Semin Intervent Radiol 2007; 24 (04) 382-390
  • 7 Mukund A, Gamanagatti S. Ethanol ablation of renal cell carcinoma for palliation of symptoms in advanced disease. J Palliat Med 2010; 13 (02) 117-120
  • 8 Gu Y-K, Luo RG, Huang JH, Si Tu QJ, Li XX, Gao F. Transarterial embolization ablation of hepatocellular carcinoma with a lipiodol-ethanol mixture. World J Gastroenterol 2010; 16 (45) 5766-5772
  • 9 Erinjeri JP, Salhab HM, Covey AM, Getrajdman GI, Brown KT. Arterial patency after repeated hepatic artery bland particle embolization. J Vasc Interv Radiol 2010; 21 (04) 522-526
  • 10 Mara M, Maskova J, Fucikova Z, Kuzel D, Belsan T, Sosna O. Midterm clinical and first reproductive results of a randomized controlled trial comparing uterine fibroid embolization and myomectomy. Cardiovasc Intervent Radiol 2008; 31 (01) 73-85
  • 11 Idée J-M, Guiu B. Use of Lipiodol as a drug-delivery system for transcatheter arterial chemoembolization of hepatocellular carcinoma: a review. Crit Rev Oncol Hematol 2013; 88 (03) 530-549
  • 12 Fiorentini G, Aliberti C, Tilli M. et al. Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a phase III study. Anticancer Res 2012; 32 (04) 1387-1395
  • 13 Lo C-M, Ngan H, Tso WK. et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 2002; 35 (05) 1164-1171
  • 14 Ishikawa H, Kikkawa F, Tamakoshi K. et al. Distribution of platinum in human gynecologic tissues and lymph nodes after intravenous and intraarterial neoadjuvant chemotherapy. Anticancer Res 1996; 16 (6B): 3849-3853
  • 15 Garattini S. Pharmacokinetics in cancer chemotherapy. Eur J Cancer 2007; 43 (02) 271-282
  • 16 Jarząbek M, Jargiełło T, Wolski A, Poluha P, Szczerbo-Trojanowska M. Drug-eluting microspheres transarterial chemoembolization (DEM TACE) in patients with liver metastases. Pilot study. Pol J Radiol 2011; 76 (03) 26-32
  • 17 Loewe C, Schindl M, Cejna M, Niederle B, Lammer J, Thurnher S. Permanent transarterial embolization of neuroendocrine metastases of the liver using cyanoacrylate and lipiodol: assessment of mid- and long-term results. AJR Am J Roentgenol 2003; 180 (05) 1379-1384
  • 18 Habib A, Desai K, Hickey R, Thornburg B, Lewandowski R, Salem R. Transarterial approaches to primary and secondary hepatic malignancies. Nat Rev Clin Oncol 2015; 12 (08) 481-489
  • 19 Wang MQ, Zhang JL, Duan F. et al. Prostate arterial chemoembolization for treatment of refractory hematuria and urinary retention in patients with localized advanced prostate cancer. Prostate Cancer Prostatic Dis 2022; DOI: 10.1038/s41391-022-00516-7.
  • 20 Song J, Chen W, Zhu X. et al. Short-term efficacy, safety, and cost-effectiveness of transarterial chemoembolization with drug-eluting beads versus synchronous radiochemotherapy for cervical cancer. Int J Gynaecol Obstet 2019; 147 (01) 29-35
  • 21 Zeng Y, Yin M, Zhao Y. et al. Combination of bronchial arterial infusion chemotherapy plus drug-eluting embolic transarterial chemoembolization for treatment of advanced lung cancer-a retrospective analysis of 23 patients. J Vasc Interv Radiol 2020; 31 (10) 1645-1653
  • 22 Jiang C, Wang J, Wang Y. et al. Treatment outcome following transarterial chemoembolization in advanced bone and soft tissue sarcomas. Cardiovasc Intervent Radiol 2016; 39 (10) 1420-1428
  • 23 Karalli A, Ghaffarpour R, Axelsson R. et al. Transarterial chemoembolization of renal cell carcinoma: a prospective controlled trial. J Vasc Interv Radiol 2017; 28 (12) 1664-1672
  • 24 Requejo F, Marelli J, Ruiz Johnson A, Sampor C, Chantada G. The technique of superselective ophthalmic artery chemotherapy for retinoblastoma: the Garrahan Hospital experience. Interv Neuroradiol 2018; 24 (01) 93-99
  • 25 Shaaban S, Negm A, Ibrahim EE, Elrazak AA. Chemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of action. Oncol Rev 2014; 8 (01) 246
  • 26 Alghorabi AA, Kabel AM, Elmaaboud M. Doxorubicin: insights into dynamics, clinical uses and adverse effects. J Cancer Res 2019; 7: 17-20
  • 27 Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, Takashima S. Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 1983; 148 (02) 397-401
  • 28 Mihlon F, Ray CE, Messersmith W. Chemotherapy agents: a primer for the interventional radiologist. Semin Intervent Radiol 2010; 27 (04) 384-390
  • 29 Fiorentini G, Sarti D, Nani R, Aliberti C, Fiorentini C, Guadagni S. Updates of colorectal cancer liver metastases therapy: review on DEBIRI. Hepat Oncol 2020; 7 (01) HEP16
  • 30 Toskich BB, Liu DM. Y90 radioembolization dosimetry: concepts for the interventional radiologist. Tech Vasc Interv Radiol 2019; 22 (02) 100-111
  • 31 Kallini JR, Gabr A, Salem R, Lewandowski RJ. Transarterial radioembolization with yttrium-90 for the treatment of hepatocellular carcinoma. Adv Ther 2016; 33 (05) 699-714
  • 32 Sato KT, Lewandowski RJ, Mulcahy MF. et al. Unresectable chemorefractory liver metastases: radioembolization with 90Y microspheres – safety, efficacy, and survival. Radiology 2008; 247 (02) 507-515
  • 33 Mohamed M, Katz AW, Tejani MA. et al. Comparison of outcomes between SBRT, yttrium-90 radioembolization, transarterial chemoembolization, and radiofrequency ablation as bridge to transplant for hepatocellular carcinoma. Adv Radiat Oncol 2015; 1 (01) 35-42
  • 34 Mouli SK, Raiter S, Harris K. et al. Yttrium-90 radioembolization to the prostate gland: proof of concept in a canine model and clinical translation. J Vasc Interv Radiol 2021; 32 (08) 1103-1112 .e12
  • 35 Murali N, Mouli SK, Riaz A, Lewandowski RJ, Salem R. Extrahepatic applications of yttrium-90 radioembolization. Semin Intervent Radiol 2021; 38 (04) 479-481
  • 36 Sacco R, Conte C, Tumino E. et al. Transarterial radioembolization for hepatocellular carcinoma: a review. J Hepatocell Carcinoma 2016; 3: 25-29
  • 37 Navalkissoor S, Grossman A. Targeted alpha particle therapy for neuroendocrine tumours: the next generation of peptide receptor radionuclide therapy. Neuroendocrinology 2019; 108 (03) 256-264
  • 38 Kim K, Kim S-J. Lu-177-based peptide receptor radionuclide therapy for advanced neuroendocrine tumors. Nucl Med Mol Imaging 2018; 52 (03) 208-215
  • 39 Bouvry C, Palard X, Edeline J. et al. Transarterial radioembolization (TARE) agents beyond 90Y-microspheres. BioMed Res Int 2018; 2018: 1435302
  • 40 Kanai T, Monden N, Sakon M. et al. A New Approach to the Treatment of Hepatocellular Carcinoma with Intrahepatic Metastases—Transarterial Immuno-Embolization (TIE) with OK-432 and Fibrinogen. In: Recent Advances in Management of Digestive Cancers. Springer; 1993: 669-671
  • 41 Valsecchi ME, Terai M, Eschelman DJ. et al. Double-blinded, randomized phase II study using embolization with or without granulocyte-macrophage colony-stimulating factor in uveal melanoma with hepatic metastases. J Vasc Interv Radiol 2015; 26 (04) 523-32 .e2
  • 42 Sato T, Eschelman DJ, Gonsalves CF. et al. Immunoembolization of malignant liver tumors, including uveal melanoma, using granulocyte-macrophage colony-stimulating factor. J Clin Oncol 2008; 26 (33) 5436-5442
  • 43 Shen L, Qi H, Chen S. et al. Cryoablation combined with transarterial infusion of pembrolizumab (CATAP) for liver metastases of melanoma: an ambispective, proof-of-concept cohort study. Cancer Immunol Immunother 2020; 69 (09) 1713-1724
  • 44 Chargari C, Deutsch E, Blanchard P. et al. Brachytherapy: an overview for clinicians. CA Cancer J Clin 2019; 69 (05) 386-401
  • 45 Gu YK, Fan WJ, Huang JH, Zhang L, Gao F. [Efficacy of CT-guided intra-tumoral dehydrated ethanol injection on lung metastasis from liver cancer]. Chin J Cancer 2007; 26 (10) 1112-1115
  • 46 Liang Y. et al. Transcatheter arterial chemoembolization combined with CT-guided percutaneous intratumor ethanol injection for liver metastases. Zhongguo Jieru Yingxiang Yu Zhiliaoxue 2007; 4 (01) 49-51
  • 47 Paz-Fumagalli R, Li X, Smallridge RC. Ethanol ablation of neck metastases from differentiated thyroid carcinoma. Semin Intervent Radiol 2019; 36 (05) 381-385
  • 48 Yamashita TS, Rogers RT, Foster TR. et al. Ultrasound-guided percutaneous ethanol ablation for local regional recurrence of medullary thyroid cancer. Am Surg 2021; 87 (09) 1396-1399
  • 49 Tselikas L, Champiat S, Sheth RA. et al. Interventional radiology for local immunotherapy in oncology. Clin Cancer Res 2021; 27 (10) 2698-2705
  • 50 Raja J, Ludwig JM, Gettinger SN, Schalper KA, Kim HS. Oncolytic virus immunotherapy: future prospects for oncology. J Immunother Cancer 2018; 6 (01) 140