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CC BY 4.0 · European J Pediatr Surg Rep. 2022; 10(01): e160-e163
DOI: 10.1055/s-0042-1759546
Case Report

Bilateral Native Kidney Papillary Renal Cell Carcinomas in a 11-Year-Old Renal Transplant Patient

Çiğdem Ulukaya Durakbaşa
1   Department of Pediatric Surgery, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey
2   Department of Pediatric Surgery, Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul, Turkey
,
Deniz Ugurlu
1   Department of Pediatric Surgery, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey
,
Sabriye Gulcin Bozbeyoglu
3   Department of Radiology, Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul, Turkey
,
Sinem Aydoner
1   Department of Pediatric Surgery, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey
,
Hatice Seneldir
4   Department of Pathology, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey
,
Mehmet Onur Candir
5   Department of Pediatric Oncology, Goztepe Prof Dr Suleyman Yalcin City Hospital, Istanbul, Turkey
,
Cengiz Candan
6   Department of Pediatric Nephrology, Istanbul Medeniyet University Faculty of Medicine, Uskudar, Istanbul, Turkey
,
Atilla Gemici
7   Department of Pediatric Nephrology, Baskent University Istanbul Hospital, Istanbul, Turkey
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Abstract

Renal cell carcinomas (RCCs) are the most common renal tumors in adults and are usually sporadic and unilateral. Renal transplant recipients have an increased risk of developing RCC. RCC development after kidney transplantation is very rarely reported in children. We present a 11-year-old boy who had cadaveric kidney transplantation for kidney failure 2 years ago. He was under immunosuppressive therapy and presented with microscopic hematuria. An ultrasound (US) revealed bilateral solid renal masses. Further cross-sectional imaging showed a 60 × 70 × 60-mm right renal mass with claw sign and a 5 × 6 × 6-mm mass in the left renal lower pole. A bilateral radical nephroureterectomy of native kidneys was performed. The pathology revealed bilateral papillary RCC without TFE3 upregulation. The patient was kept on low-dose immunosuppressive therapy in the perioperative period. He received no chemotherapy but a close radiological surveillance was undertaken. He is tumor-free 2 years after the operation. RCC is a rare tumor for children and bilateralism is even rarer. The child had a history of chronic kidney disease, peritoneal dialysis, and immunosuppressive therapy. As there are no standardized protocols regarding imaging in transplanted kidneys routine surveillance, US follow-up should also focus on detecting malignancy.

Keywords

renal cell carcinoma - bilateral - transplantation - native kidney - child


Publication History

Received: 22 May 2022

Accepted: 04 October 2022

Article published online:
04 December 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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