Semin Plast Surg 2023; 37(01): 039-045
DOI: 10.1055/s-0042-1759797
Review Article

Management of Palatal Defects after Free-Flap Reconstruction and Radiotherapy

Wesley McIlwain
1   Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas
,
Jared Inman
2   Otolaryngology/Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, California
,
Arya Namin
1   Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas
,
Aasif Kazi
2   Otolaryngology/Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, California
,
Christopher Shumrick
3   Department of Otolaryngology-Head and Neck Surgery, Tufts Medical Center, Boston, Massachusetts
,
Yadranko Ducic
1   Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas
› Author Affiliations

Abstract

Palatal fistulas have significant effects on quality of life. Traditional prosthetic rehabilitation and surgical reconstruction of palate defects in radiation-naïve tissues are well described. However, palatal fistulas developing after initial tumor extirpation, free-flap reconstruction, and adjuvant radiation or chemoradiation are associated with challenging secondary tissue effects. In this review, we will discuss the management of palatal fistulas after surgical reconstruction and radiotherapy.



Publication History

Article published online:
22 December 2022

© 2022. Thieme. All rights reserved.

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  • References

  • 1 Urken ML, Roche AM, Kiplagat KJ. et al. Comprehensive approach to functional palatomaxillary reconstruction using regional and free tissue transfer: Report of reconstructive and prosthodontic outcomes of 140 patients. Head Neck 2018; 40 (08) 1639-1666
  • 2 Moreno MA, Skoracki RJ, Hanna EY, Hanasono MM. Microvascular free flap reconstruction versus palatal obturation for maxillectomy defects. Head Neck 2010; 32 (07) 860-868
  • 3 Cordeiro PG, Chen CM. A 15-year review of midface reconstruction after total and subtotal maxillectomy: part I. Algorithm and outcomes. Plast Reconstr Surg 2012; 129 (01) 124-136
  • 4 Brown JS, Shaw RJ. Reconstruction of the maxilla and midface: introducing a new classification. Lancet Oncol 2010; 11 (10) 1001-1008
  • 5 Okay DJ, Genden E, Buchbinder D, Urken M. Prosthodontic guidelines for surgical reconstruction of the maxilla: a classification system of defects. J Prosthet Dent 2001; 86 (04) 352-363
  • 6 Vincent A, Burkes J, Williams F, Ducic Y. Free flap reconstruction of the maxilla. Semin Plast Surg 2019; 33 (01) 30-37
  • 7 Bristol IJ, Ahamad A, Garden AS. et al. Postoperative radiotherapy for maxillary sinus cancer: long-term outcomes and toxicities of treatment. Int J Radiat Oncol Biol Phys 2007; 68 (03) 719-730
  • 8 Vahidi N, Lee TS, Daggumati S, Shokri T, Wang W, Ducic Y. Osteoradionecrosis of the midface and mandible: pathogenesis and management. Semin Plast Surg 2020; 34 (04) 232-244
  • 9 Bernstein EF, Sullivan FJ, Mitchell JB, Salomon GD, Glatstein E. Biology of chronic radiation effect on tissues and wound healing. Clin Plast Surg 1993; 20 (03) 435-453
  • 10 Sharif KF, Sims JR, Yue LE. et al. Reconstructive and prosthodontic outcomes after multiple palatomaxillary reconstructions. Laryngoscope 2020; 130 (10) 2349-2353
  • 11 Shokri T, Wang W, Vincent A, Cohn JE, Kadakia S, Ducic Y. Osteoradionecrosis of the maxilla: conservative management and reconstructive considerations. Semin Plast Surg 2020; 34 (02) 106-113
  • 12 Lerner DK, Filimonov A, Filip P. et al. Sinonasal issues after maxillectomy with free flap reconstruction: incidence and clinical approach. Laryngoscope 2022; 132 (01) 67-72
  • 13 Mayland E, Curry JM, Wax MK. et al. Impact of preoperative and intraoperative management on outcomes in osteoradionecrosis requiring free flap reconstruction. Head Neck 2022; 44 (03) 698-709
  • 14 Dort JC, Farwell DG, Findlay M. et al. Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction: a consensus review and recommendations from the enhanced recovery after surgery society. JAMA Otolaryngol Head Neck Surg 2017; 143 (03) 292-303
  • 15 Lee ZH, Cripps C, Rodriguez ED. Current concepts in maxillary reconstruction. Plast Reconstr Surg 2022; 150 (01) 168e-175e
  • 16 Pool C, Shokri T, Vincent A, Wang W, Kadakia S, Ducic Y. Prosthetic reconstruction of the maxilla and palate. Semin Plast Surg 2020; 34 (02) 114-119
  • 17 Kim DD, Ghali GE. Dental implants in oral cancer reconstruction. Dent Clin North Am 2011; 55 (04) 871-882
  • 18 Mijiti A, Kuerbantayi N, Zhang ZQ, Su MY, Zhang XH, Huojia M. Influence of preoperative radiotherapy on head and neck free-flap reconstruction: Systematic review and meta-analysis. Head Neck 2020; 42 (08) 2165-2180
  • 19 Miller H, Bush K, Delancy M. et al. Effect of preoperative radiation on free flap outcomes for head and neck reconstruction: an updated systematic review and meta-analysis. J Plast Reconstr Aesthet Surg 2022; 75 (02) 743-752
  • 20 Benatar MJ, Dassonville O, Chamorey E. et al. Impact of preoperative radiotherapy on head and neck free flap reconstruction: a report on 429 cases. J Plast Reconstr Aesthet Surg 2013; 66 (04) 478-482
  • 21 Cordeiro PG, Chen CM. A 15-year review of midface reconstruction after total and subtotal maxillectomy: part II. Technical modifications to maximize aesthetic and functional outcomes. Plast Reconstr Surg 2012; 129 (01) 139-147
  • 22 Sanchez A, Frank E, Inman J, Wang W, Namin A, Ducic Y. Fistula management in head and neck cancer. Semin Plast Surg 2020; 34 (04) 299-304
  • 23 Moubayed SP, Osorio M, Buchbinder D, Lazarus C, Urken ML. Soft palate reconstruction using a combination of a turn-in flap and a radial forearm flap. Laryngoscope 2017; 127 (08) 1772-1774
  • 24 Genden EM, Lee BB, Urken ML. The palatal island flap for reconstruction of palatal and retromolar trigone defects revisited. Arch Otolaryngol Head Neck Surg 2001; 127 (07) 837-841
  • 25 Karle WE, Anand SM, Clain JB, Scherl S, Urken ML. Total soft palate reconstruction using the palatal island and lateral pharyngeal wall flaps. Laryngoscope 2013; 123 (04) 929-933
  • 26 Rosenthal E, Carroll W, Dobbs M, Scott Magnuson J, Wax M, Peters G. Simplifying head and neck microvascular reconstruction. Head Neck 2004; 26 (11) 930-936
  • 27 Ayad T, Xie L. Facial artery musculomucosal flap in head and neck reconstruction: a systematic review. Head Neck 2015; 37 (09) 1375-1386
  • 28 Pribaz J, Stephens W, Crespo L, Gifford G. A new intraoral flap: facial artery musculomucosal (FAMM) flap. Plast Reconstr Surg 1992; 90 (03) 421-429
  • 29 Braasch DC, Lam D, Oh ES. Maxillofacial reconstruction with nasolabial and facial artery musculomucosal flaps. Oral Maxillofac Surg Clin North Am 2014; 26 (03) 327-333
  • 30 Bozola AR, Gasques JA, Carriquiry CE, Cardoso de Oliveira M. The buccinator musculomucosal flap: anatomic study and clinical application. Plast Reconstr Surg 1989; 84 (02) 250-257
  • 31 Comini LV, Spinelli G, Mannelli G. Algorithm for the treatment of oral and peri-oral defects through local flaps. J Craniomaxillofac Surg 2018; 46 (12) 2127-2137
  • 32 Bradley P, Brockbank J. The temporalis muscle flap in oral reconstruction. A cadaveric, animal and clinical study. J Maxillofac Surg 1981; 9 (03) 139-145
  • 33 Browne JD, Butler S, Rees C. Functional outcomes and suitability of the temporalis myofascial flap for palatal and maxillary reconstruction after oncologic resection. Laryngoscope 2011; 121 (06) 1149-1159
  • 34 Lam D, Carlson ER. The temporalis muscle flap and temporoparietal fascial flap. Oral Maxillofac Surg Clin North Am 2014; 26 (03) 359-369
  • 35 Al Deek NF, Wei FC, Tsao CK. Fistulae after successful free tissue transfer to head and neck: its prevention and treatment. Clin Plast Surg 2016; 43 (04) 739-745
  • 36 Nguyen S, Tran KL, Wang E, Britton H, Durham JS, Prisman E. Maxillectomy defects: virtually comparing fibular and scapular free flap reconstructions. Head Neck 2021; 43 (09) 2623-2633
  • 37 Sokoya M, Bahrami A, Vincent A. et al. Preoperative radiation and complication rates after double free flap reconstruction of head and neck cancer. Am J Otolaryngol 2018; 39 (05) 558-560
  • 38 Guillemaud JP, Seikaly H, Cote DW. et al. Double free-flap reconstruction: indications, challenges, and prospective functional outcomes. Arch Otolaryngol Head Neck Surg 2009; 135 (04) 406-410
  • 39 Cordeiro PG, Bacilious N, Schantz S, Spiro R. The radial forearm osteocutaneous “sandwich” free flap for reconstruction of the bilateral subtotal maxillectomy defect. Ann Plast Surg 1998; 40 (04) 397-402
  • 40 Andrades P, Bohannon IA, Baranano CF, Wax MK, Rosenthal E. Indications and outcomes of double free flaps in head and neck reconstruction. Microsurgery 2009; 29 (03) 171-177
  • 41 Funk GF. Scapular and parascapular free flaps. Facial Plast Surg 1996; 12 (01) 57-63
  • 42 Eskander A, Kang SY, Ozer E. et al. Supine positioning for the subscapular system of flaps: a pictorial essay. Head Neck 2018; 40 (05) 1068-1072
  • 43 Blackwell KE, Urken ML. Iliac crest free flap. Facial Plast Surg 1996; 12 (01) 35-43
  • 44 Brown JS. Deep circumflex iliac artery free flap with internal oblique muscle as a new method of immediate reconstruction of maxillectomy defect. Head Neck 1996; 18 (05) 412-421
  • 45 Genden EM, Wallace D, Buchbinder D, Okay D, Urken ML. Iliac crest internal oblique osteomusculocutaneous free flap reconstruction of the postablative palatomaxillary defect. Arch Otolaryngol Head Neck Surg 2001; 127 (07) 854-861
  • 46 Dziegielewski PT, Rieger J, Shama MA, O'Connell DA, Harris JR, Seikaly H. Beavertail modification of the radial forearm free flap in total oral glossectomy reconstruction: technique and functional outcomes. Oral Oncol 2019; 96: 71-76
  • 47 Kim JH, Rosenthal EL, Ellis T, Wax MK. Radial forearm osteocutaneous free flap in maxillofacial and oromandibular reconstructions. Laryngoscope 2005; 115 (09) 1697-1701
  • 48 Villaret DB, Futran NA. The indications and outcomes in the use of osteocutaneous radial forearm free flap. Head Neck 2003; 25 (06) 475-481
  • 49 Sinclair CF, Gleysteen JP, Zimmermann TM. et al. Assessment of donor site morbidity for free radial forearm osteocutaneous flaps. Microsurgery 2012; 32 (04) 255-260
  • 50 Ahmad FI, Means C, Labby AB. et al. Osteocutaneous radial forearm free flap in nonmandible head and neck reconstruction. Head Neck 2017; 39 (09) 1888-1893
  • 51 Chepeha DB, Moyer JS, Bradford CR, Prince ME, Marentette L, Teknos TN. Osseocutaneous radial forearm free tissue transfer for repair of complex midfacial defects. Arch Otolaryngol Head Neck Surg 2005; 131 (06) 513-517
  • 52 Wong CH, Wei FC. Anterolateral thigh flap. Head Neck 2010; 32 (04) 529-540
  • 53 Coskunfirat OK, Wei FC, Huang WC, Cheng MH, Yang WG, Chang YM. Microvascular free tissue transfer for treatment of osteoradionecrosis of the maxilla. Plast Reconstr Surg 2005; 115 (01) 54-60
  • 54 Vaidya S, Parkash H, Gupta S, Bhargava A, Kapoor C. Two-piece hollow bulb obturator for postsurgical partial maxillectomy defect in a young patient revamping lost malar prominence: a clinical report. J Prosthodont 2016; 25 (01) 71-76
  • 55 Schmidt BL, Pogrel MA, Young CW, Sharma A. Reconstruction of extensive maxillary defects using zygomaticus implants. J Oral Maxillofac Surg 2004; 62 (9, Suppl 2): 82-89
  • 56 Ramezanzade S, Yates J, Tuminelli FJ, Keyhan SO, Yousefi P, Lopez-Lopez J. Zygomatic implants placed in atrophic maxilla: an overview of current systematic reviews and meta-analysis. Maxillofac Plast Reconstr Surg 2021; 43 (01) 1
  • 57 Chuka R, Abdullah W, Rieger J. et al. Implant utilization and time to prosthetic rehabilitation in conventional and advanced fibular free flap reconstruction of the maxilla and mandible. Int J Prosthodont 2017; 30 (03) 289-294
  • 58 Patel A, Harrison P, Cheng A, Bray B, Bell RB. Fibular reconstruction of the maxilla and mandible with immediate implant-supported prosthetic rehabilitation: jaw in a day. Oral Maxillofac Surg Clin North Am 2019; 31 (03) 369-386