Curcuma longa in der Onkologie

Zusammenfassung

Curcuma longa wird seit Jahrtausenden in der ayurvedischen und chinesischen Medizin bei zahlreichen Erkrankungen eingesetzt. Im Mittelpunkt der Forschung steht überwiegend Curcumin, ein wesentlicher Bestandteil des Extrakts. In-vitro- und In-vivo-Studien haben vielfältige Wirkmechanismen u. a. antioxidative und antiinflammatorische Wirkungen aufgezeigt. Bei zahlreichen Erkrankungen, v. a. mit entzündlicher Genese sowie bei Tumorerkrankungen, hat sich der Einsatz von Curcumin als effektiv erwiesen. Curcumin beeinflusst alle Signalwege von der Karzinogenese bis zur Metastasierung. Formulierungen mit verbesserter Bioverfügbarkeit sowie neue Applikationsformen versuchen pharmakologische Schwächen des Pflanzenstoffes auszugleichen. Aktuell werden in Patientenstudien z. B. Kombinationen mit Chemotherapien und Strahlentherapien erprobt. Daneben sind aber auch Kombinationen von Curcuma mit anderen Pflanzenstoffen zur Optimierung therapeutischer Effekte in der integrativen Onkologie von großem Interesse.

Abstract

Curcuma longa has been used for thousands of years in Ayurvedic and Chinese medicine for various diseases. The focus of research is predominantly on curcumin, an essential component of the extract. In vitro as well as in vivo studies have shown various mechanisms of action such as antioxidant, anti-inflammatory effects. The use of curcumin has proven to be effective in numerous diseases, including inflammatory genesis and tumor diseases. Curcumin affects all signaling pathways from carcinogenesis to metastasis. Formulations with improved bioavailability as well as new forms of application attempt to balance pharmacological weaknesses of the plant material. Currently, combinations of chemotherapies and radiation therapies are tested in patient studies. In addition, combinations of curcuma longa with other plants are also of great interest for the optimization of therapeutic effects in integrative oncology.

Schlüsselwörter

Curcuma - Kurkuma - Curcumin - Kurkumin - Bioverfügbarkeit - Onkologie - klinische Studie

Key words

Curcumin - inflammation - bioavailability - application - clinical trial

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