Update Mammakarzinom 2018 (Teil 1) – primäres Mammakarzinom und Biomarker

Florin-Andrei Taran; Andreas Schneeweiss; Michael P. Lux; Wolfgang Janni; Andreas D. Hartkopf; Naiba Nabieva; Friedrich Overkamp; Hans-Christian Kolberg; Peyman Hadji; Hans Tesch; Achim Wöckel; Johannes Ettl; Diana Lüftner; Markus Wallwiener; Volkmar Müller; Matthias W. Beckmann; Erik Belleville; Diethelm Wallwiener; Sara Y. Brucker; Peter A. Fasching; Tanja N. Fehm; Florian Schütz

doi:10.1055/s-0043-124849

Senologie - Zeitschrift für Mammadiagnostik und -therapie, Table of Contents

Senologie - Zeitschrift für Mammadiagnostik und -therapie 2018; 15(02): 86-94
DOI: 10.1055/s-0043-124849

Wissenschaftliche Arbeit

Georg Thieme Verlag KG Stuttgart · New York

Update Mammakarzinom 2018 (Teil 1) – primäres Mammakarzinom und Biomarker

Update Breast Cancer 2018 (Part 1) – Primary Breast Cancer and Biomarkers

Florin-Andrei Taran

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen

,

Andreas Schneeweiss

²National Center for Tumor Diseases, Division Gynecologic Oncology, University Hospital Heidelberg, Heidelberg

³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg

,

Michael P. Lux

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

,

Wolfgang Janni

⁵Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm

,

Andreas D. Hartkopf

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen

,

Naiba Nabieva

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

,

Friedrich Overkamp

⁶OncoConsult Hamburg GmbH, Hamburg

,

Hans-Christian Kolberg

⁷Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop

,

Peyman Hadji

⁸Department of Bone Oncology, Nordwest Hospital, Frankfurt

,

Hans Tesch

⁹Oncology Practice at Bethanien Hospital Frankfurt, Frankfurt

,

Achim Wöckel

¹⁰Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg

,

Johannes Ettl

¹¹Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich

,

Diana Lüftner

¹²Charité University Hospital, Berlin, Campus Benjamin Franklin, Department of Hematology, Oncology and Tumour Immunology, Berlin

,

Markus Wallwiener

³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg

,

Volkmar Müller

¹³Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg

,

Matthias W. Beckmann

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

,

Erik Belleville

¹⁴ClinSol GmbH & Co KG, Würzburg

,

Diethelm Wallwiener

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen

,

Sara Y. Brucker

¹Department of Obstetrics and Gynecology, University of Tübingen, Tübingen

,

Peter A. Fasching

⁴Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen

,

Tanja N. Fehm

¹⁵Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf

,

Florian Schütz

³Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg

› Author Affiliations

Abstract

Zusammenfassung

In dieser Übersichtsarbeit wird dargestellt, wie neue Therapien oder neue Aspekte etablierter Therapien in Zusammenhang mit neuesten, aktuellen Erkenntnissen stehen. Neoadjuvanz, Lokaltherapie, neue Aspekte der Systemtherapie und Prognose- sowie Prädiktivfaktoren werden beleuchtet. In der Neoadjuvanz ist nach wie vor der Zusammenhang zwischen pCR und Prognose von Interesse, ebenso wie neue molekulare Prädiktoren für neue Therapien wie CDK4/6-Inhibitoren zu identifizieren. Bei der operativen Behandlung wird weiter nach einer Reduktion der Aggressivität gestrebt. Insbesondere das duktale Carcinoma in situ muss dafür noch besser verstanden werden. Bei den Systemtherapien wächst die Datenlage zum Verständnis der besten Kombinationen und Therapieabläufe für bestehende Therapieverfahren. Letztendlich muss mithilfe von Prognose- und Prädiktivfaktoren vermieden werden, dass Übertherapien stattfinden und nur die Patientin spezifische Therapien erhält, welche bei dieser individuellen Patientin eine nachgewiesene Wirksamkeit mit wenig Nebenwirkungen haben.

Abstract

This summary provides an overview of how new therapies or new aspects of established therapies relate to the latest findings. Neoadjuvant therapy, local therapy, new aspects of systemic therapy, and prognostic and predictive factors are presented. In the neoadjuvant setting, the association between pathological complete response (pCR) and prognosis is still of interest as is the identification of new molecular predictors for new therapies such as CDK4/6 inhibitors. As regards surgical treatment, the target is still to reduce the aggressiveness of surgery. To achieve this, a better understanding particularly of ductal carcinoma in situ is required. With regard to systemic therapy, more data on the best combinations and therapy sequences for existing therapies is available. Finally, the use of prognostic and predictive factors may help to avoid overtreatment and ensure that patients only receive therapies which have been shown to be effective for their specific condition and have fewer side effects.

Schlüsselwörter

Mammakarzinom - Behandlung - Lokalrezidiv - Studien - Prognosefaktoren - Prädiktivfaktoren

Key words

breast cancer - treatment/therapy - local recurrence - trials - prognostic factors - predictive factors

Full Text

References

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