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CC BY 4.0 · Journal of Health and Allied Sciences NU 2024; 14(01): 054-065
DOI: 10.1055/s-0043-1762915
Review Article

Vitamin D and its Relationship to Ocular Diseases: A Systematic Review

Rubén David dos Reis Zuniga 
1   Discipline of Ophthalmology, Centro Universitário FMABC, Santo André, Brazil
,
Miguel Vida Lamegal
1   Discipline of Ophthalmology, Centro Universitário FMABC, Santo André, Brazil
,
Danielle Bueno Rodrigues
1   Discipline of Ophthalmology, Centro Universitário FMABC, Santo André, Brazil
,
Glaucia Luciano da Veiga
1   Discipline of Ophthalmology, Centro Universitário FMABC, Santo André, Brazil
2   Laboratory of Clinical Analysis, Centro Universitário FMABC, Santo André, Brazil
,
Edimar Cristiano Pereira 
3   Department of Pharmaceutical Sciences, Universidade Federal de São Paulo/UNIFESP—Diadema, Brasil
,
Thaís Moura Gascón
2   Laboratory of Clinical Analysis, Centro Universitário FMABC, Santo André, Brazil
,
Beatriz da Costa Aguiar Alves
2   Laboratory of Clinical Analysis, Centro Universitário FMABC, Santo André, Brazil
,
Renato Galão Cerquinho Leça
1   Discipline of Ophthalmology, Centro Universitário FMABC, Santo André, Brazil
,
Vagner Loduca Lima
1   Discipline of Ophthalmology, Centro Universitário FMABC, Santo André, Brazil
,
Fernando Luiz Affonso Fonseca
2   Laboratory of Clinical Analysis, Centro Universitário FMABC, Santo André, Brazil
3   Department of Pharmaceutical Sciences, Universidade Federal de São Paulo/UNIFESP—Diadema, Brasil
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Abstract

Introduction Vitamin D plays a vital role in the proper functioning of various systems of the human body. Conventionally, it is known that its deficiency can impair, among other factors, calcium homeostasis, bone metabolism, and immune system regulation. Besides having anti-inflammatory and antiangiogenic properties, 25(OH)D also acts in maintaining the integrity of the human retina, favoring the idea of it being a protective factor for certain ocular diseases.

Objective Therefore, the purpose of this review was to collect data from the literature which support the importance of vitamin D for ocular health.

Methods Through the Scientific Electronic Library Online and the National Library of Medicine databases, a compendium was created on the subject.

Results In total, 31 articles in English published between 2016 and 2020 were found. These articles were reviewed and categorized by diseases in order to study each disorder thoroughly. It is noticed that 25(OH) D is, in fact, a potential protective factor against such diseases, including diseases that affect both the surface of the cornea and the ocular tissues that have vitamin D receptors.

Conclusion Vitamin D is a protective hormone in the eye, and its deficiency is related to a variety of ocular diseases. Therefore, the supplementation of 25(OH)D can be considered as a complementary treatment for patients with these diseases, since it brings relevant benefits.

Keywords

Vitamin D - 25(OH)D - ocular diseases - serum levels - systematic review


Publikationsverlauf

Artikel online veröffentlicht:
14. April 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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